Clinical trials: Oral Cavity Disease
Oral Infection, Ventilator-associated Pneumonia
Evaluating the Effectiveness of the Tongue Cleaner in Critical Patients
The concern with oral infection and its systemic repercussions is old, many studies have been undertaken to establish this relationship more precisely.
- Trial name
- NCT01294943
- Testing
- Tongue cleaner
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Mucositis
Therapies for Salivary Flux Stimulation in Patients Transplanted With Hematopoietic Stem Cells
The transplantation of hematopoietic stem cells (THSC) is a therapeutic modality developed for the treatment of various diseases such as leukemia, bone marrow aplasia, lymphomas, multiple myeloma, among others.
- Trial name
- NCT00929825
- Testing
- mechanical stimulation (Elastomers), TENS
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Partial Edentulism Class II, Dental Implants
Porcelain-fused-to-metal Versus Zirconia Implant- Supported in Mandibular Kennedy Class II
The goal of this randomized clinical trial is to compare biting force and patient satisfaction in three groups. Patients in the control group number one will receive a CoCr removable partial denture, and in the other two groups…
- Conditions
- Partial Edentulism Class II, Dental Implants, Implant
- Trial name
- NCT06150768
- Testing
- Cobalt Chromium Removable Partial Denture, Implant-Supported Porcelain-Fused-to-Metal-Fixed Partial Denture, Implant-Supported Zirconia Fixed Partial Denture.
- Where
- Egypt
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cleft Lip, Cleft Palate
Oral Cleft Prevention Program
The purpose of this study is to asses if taking 4 mg of folic acid per day at preconception and during the first three months of pregnancy decreases the risk of having a child with cleft lip and palate compared to 0.4 mg folic…
- Trial name
- NCT00397917
- Testing
- Folic acid: 4 mg versus 0.4 mg per day
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- University of Iowa
Coronary Artery Disease
Vericiguat Drug-drug Interaction With Nitroglycerin in Stable Coronary Artery Disease Patients
This study is intended to investigate the effect of nitroglycerin on vericiguat in patients with stable coronary artery disease (CAD). Nitroglycerin is the standard therapy to treat acute crisis of angina.
- Trial name
- VENICE (NCT02617550)
- Testing
- Vericiguat (BAY1021189), Nitroglycerin
- Where
- 6 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Bayer
Periodontitis
1% Metformin in Moderate and Severe Periodontitis
This study evaluates the efficacy of 1% Metformin gel in treatment of moderate and severe periodontitis subject.
- Trial name
- NCT02274090
- Testing
- 1% Metformin gel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Velopharyngeal Insufficiency, Articulation Disorders
Efficacy of an Arabic Articulatory Error Remediation Software Program in Patients With Velopharyngeal Valve Dysfunction:
To develop a remediation software program that is specific for correcting speech errors in patients with velopharyngeal dysfunction in the Arabic language and test its efficacy, on one group comparing pre and post results
- Conditions
- Velopharyngeal Insufficiency, Articulation Disorders, Hypernasality Syndrome Due to Velopharyngeal Weakness
- Trial name
- NCT04392817
- Testing
- Arabic Articulatory Error Remediation software program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alaa Mamdouh
Oral Cancer, Palliative Supportive Care
Early Palliative Care For Patients With Oral Cancer in Sri Lanka
The goal of this quasi experimental study is to develop and assess the effectiveness of an early palliative care intervention in patients with oral cancer in Sri Lanka.
- Conditions
- Oral Cancer, Palliative Supportive Care, Psychological Distress, Quality of Life of Patients
- Trial name
- NCT06726317
- Testing
- Early palliative care integration
- Where
- 4 sites in Sri Lanka
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Colombo
Periodontal Diseases
Periodontal Health and Sodium Bicarbonate Toothpaste
The goal of this clinical trial is to determine whether sodium bicarbonate fluoride toothpaste can help maintain periodontal health in adults who have undergone non-surgical periodontal treatment.
- Trial name
- NCT07274189
- Testing
- no treatment received, Periodontal treatment and OHI
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Plymouth
Dermatomyositis, Polymyositis, Sjogren's, SLE, SSc
A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases
To evaluate the safety and tolerability of escalating, single subcutaneous doses of MEDI7734 in adult subjects with type I interferon-mediated autoimmune diseases.
- Trial name
- NCT02780674
- Testing
- MEDI7734
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Amgen
Dry Eye, Neuropathic Eye Pain
Azithromycin for Meibomian Gland Disease
This study aims to elucidate the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction.
- Conditions
- Dry Eye, Neuropathic Eye Pain, Ocular Microbiome, Depression, Anxiety
- Trial name
- NCT03953118
- Testing
- Azithromycin Oral Product
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Periapical Periodontitis
Evaluation of Three Irrigants, Sodium Hypochlorite, Chlorhexidine and Combination of CHX+H2O2 in Endodontic Treatment.
This study will evaluate the synergistic effect of CHX + H2O2 when used as an irrigant during biomechanical preparation.in root canal treatment on periapical healing and compared with Chlorhexidine( CHX) and Sodium Hypochlorite…
- Trial name
- NCT04373018
- Testing
- Sodium hypochlorite, Chlorhexidine, Chlorhexidine + Hydrogen peroxide
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Parkinson Disease, Oral Infection
Oral Therapeutic Education in Stimulated Parkinsonian Patients
The effect of periodontal disease on the general condition of patients remains today underestimated in Parkinson's disease. The BUCCO-PARK project aims to carry out an exploratory study of oral therapeutic education on the…
- Trial name
- BUCCO-PARK (NCT03965390)
- Testing
- Oral education
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Rennes University Hospital
Periodontitis
Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Current treatments of periodontitis have limited efficacy since they fail to suppress microorganisms satisfactorily over time. The aim of present study was to investigate whether there are differences between initial treatment of…
- Trial name
- EIPRFITCP (NCT04178590)
- Testing
- SRP + Injectable Platelet-Rich Fibrin
- Where
- Serbia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Gingival Recession, Atrophy
The Effect of Different Gingival Biotypes on Dimensional Stability of Free Gingival Graft
The aim of this study is to compare the effect of mesial and distal adjacent gingival biotypes of the tooth / teeth region of free gingival graft (FGG) on the shrinkage ratio of graft at 6 months postoperatively.
- Trial name
- NCT03616197
- Testing
- free gingival graft
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Cardiac Diseases, Muscular Weakness
Biomarker for Pompe Disease (BioPompe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Pompe disease from blood (plasma)
- Conditions
- Cardiac Diseases, Muscular Weakness, Hepato-splenomegaly, Lung Disease
- Trial name
- BioPompe (NCT01457443)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Edentulous
Full-arch Monolithic Zirconia ISFDP Follow up
This study is designed to recall all patients who have received a full-arch monolithic zirconia implant supported fixed dental prosthesis in the University of North Carolina (UNC) School of Dentistry Graduate Prosthodontic and/or…
- Trial name
- NCT02931968
- Testing
- Monolithic zirconia prosthesis
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Aggressive Periodontitis
Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP
The aim of this study is to estimate genetic impact of MCP-1 -2518 and its receptor CCR2 -190 polymorphisms on AgP patients among Turkish individuals and whether MCP-1 genotype effects mRNA levels of Peripheral Blood Mononuclear…
- Trial name
- NCT02817568
- Testing
- Drawing Blood
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Gingival Diseases
Clinical Study to Evaluate Dental Plaque
Clinical research study to determine anti-plaque efficacy of a prototype toothpastes for a 3 week brushing regiment.
- Trial name
- NCT00758290
- Testing
- Triclosan/Fluoride, Fluoride/triclosan
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Lichen Planus, Oral Leukoplakia
Biomarkers for Oral Cancer
The purpose is to determine the extent of genetic damage in oral mucosal lesions ascertained in the study, whether specific genotypes are associated with genetic damage observed in the oral mucosal lesions, whether the extent of…
- Conditions
- Lichen Planus, Oral Leukoplakia, Mouth Neoplasms
- Trial name
- NCT00341497
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
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