Clinical trials: Oral Cavity Disease
Type 2 Diabetes, Obesity & Overweight
Effects of GLP-1 Receptor Agonists on Saliva and Oral Health
This study aims to evaluate the effects of GLP-1 receptor agonists (GLP-1RA) on salivary parameters and oral health in individuals who will use this medication for the first time due to a diagnosis of Type 2 diabetes and/or…
- Conditions
- Type 2 Diabetes, Obesity & Overweight, Xerostomia, Dental Caries
- Trial name
- NCT07818226
- Testing
- GLP-1 Receptor Agonists
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kırıkkale University
Periimplantitis
Adhesion of Connective Tissue Around Laser-treated Abutments for Dental Implants - Clinical Trial in Humans
This study aims to demonstrate the histological differences in the connective tissue surrounding laser-treated abutments and untreated abutments in humans.
- Trial name
- NCT01954485
- Testing
- Dental implant placement with a final prosthetic abutment
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Barcelona
Nutrition Disorders, Gastrointestinal Disease
Review of Infant Oral Feeding and Skills
This study evaluates the infant's feeding skill level at discharge from the neonatal intensive care unit. The goal is to determine whether the ability to "full feed by volume" implies "full skill development" for infant oral…
- Conditions
- Nutrition Disorders, Gastrointestinal Disease, Deglutition Disorder, Feeding Difficulties
- Trial name
- RIOS (NCT06736743)
- Testing
- SMART Tool for Feeding Skill Assessment
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Wake Forest University Health Sciences
Gingival Recession, Gingival Recession, Localized
The Effect of Using Injectable Platelet-rich Fibrin on Root Surface Closure in Patients with Gingival Recession.
Gingival recession is the term used to describe the apical positioning of the marginal gingiva from the enamel-cementum junction.
- Trial name
- NCT05591326
- Testing
- i-PRF application procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Berceste Guler
Barrett Esophagus, Gastroesophageal Reflux
Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus
The purpose of this research study is to assess how safe, effective (how well it works), and tolerable (to put up with) the drug Zegerid is in reducing reflux episodes in patients who have both gastroesophageal reflux disease…
- Trial name
- NCT01129778
- Testing
- Zegerid (proton pump inhibitor), Bravo pH monitoring
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Stanford University
Alveolar Bone Loss, Tooth Loss
Changes of Soft and Hard Tissues After Alveolar Ridge Preservation: Freeze-dried Bone Allograft vs. L-PRF Clot
A Clinical Trial to study the effectiveness between two, tooth socket grafting materials namely, Freeze Dried Bone Allograft (human derived bone particles) and Leukocytic-Platelet Rich Fibrin (the patient's own centrifuged…
- Trial name
- NCT03331185
- Testing
- Freeze Dried Bone Allograft, L-PRF clot
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Carotid Artery Calcification, Periodontal Diseases
Assessment of Carotid Artery Calcifications
The aim of the study was to determine retrospectively the presence of carotid artery calcification (CAC) detected on digital panoramic radiographs (DPRs) and correlate the finding of such calcifications with gender, smoking…
- Trial name
- NCT04017078
- Testing
- diagnosis of carotid artery calcification on digital panoramic radiograph
- Where
- Turkey (Türkiye)
- Volunteers
- 1,101 people
- Sponsor
- Baskent University
Valvular Heart Disease Patients
Rivaroxaban vs Warfarin in Patients With Mechanical Heart Valves
Warfarin is the standard anticoagulant used for patients with mechanical heart valves; however, its use is complicated by a narrow therapeutic window, frequent drug and dietary interactions, and the need for regular international…
- Trial name
- NCT07456085
- Testing
- Rivoroxaban, Warfarin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Rawalpindi Institute of Cardiology
Advanced or Metastatic Solid Tumors
Oral Immunomodulatory Tyrosine Kinase Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors
This is a first-in-human, open label, multicenter, dose escalation study of RXDX-106 in patients with locally advanced or metastatic solid tumors, who have no available therapy likely to convey clinical benefit.
- Trial name
- TITAN (NCT03454243)
- Testing
- RXDX-106
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Hoffmann-La Roche
Edentulous Mouth
Mandibular Overdenture Retained by 1 or 2 Implants: a Cost-effectiveness Analysis
The aim of this study is to assess the cost-effectiveness of the mandibular overdenture retained by one and two implants, based on a randomized clinical trial.
- Trial name
- IOD1-2 (NCT03691285)
- Testing
- Mandibular Overdenture
- Where
- Brazil
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Gingival Recession, Gingival Diseases
Influence of Anatomical Factors Upon Root Coverage
Introduction: Gingival recession is a lesion characterized by the loss of attachment of root surface of the tooth, resulting in an apical migration of the gingival margin that occasionally generates aesthetic problems…
- Conditions
- Gingival Recession, Gingival Diseases, Periodontal Attachment Loss
- Trial name
- NCT04813302
- Testing
- Coronally advanced flap and connective tissue graft
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Cleft Palate
Improving Outcomes in Cleft Palate Surgery
This is a pilot study to determine if an audit and feedback intervention decreases complication rates after cleft palate surgery.
- Trial name
- NCT02583100
- Testing
- Intensive Feedback, Routine Feedback
- Where
- 6 sites in United States, Canada
- Volunteers
- 7 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
CML, Chronic Phase, CML, Accelerated Phase
A Study of HS-10382 in Patients With Chronic Myeloid Leukemia.
HS-10382 is a small molecular, oral potent, allosteric inhibitor. By binding a myristoyl site of the BCR-ABL1 protein, HS-10382 locks BCR-ABL1 into an inactive conformation.
- Trial name
- NCT05367700
- Testing
- HS-10382(Part 1: Dose escalation), HS-10382(Part 2: Dose expansion)
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Periodontal Disease, Metabolic Syndrome
The Relation Between Periodontal Disease and Metabolic Syndrome
Periodontal disease is associated with the components of Metabolic syndrome, such as obesity, diabetes, hypertension and hyperlipidemia. Therefore, strong relation with periodontal disease and metabolic syndrome is suggested.
- Trial name
- NCT00553007
- Testing
- Periodontal therapy
- Where
- Japan
- Volunteers
- 80 people
- Sponsor
- Aichi Gakuin University
Cleft Lip
Dexmedetomidine as Adjuvant for Bupivacaine in Ultrasound Guided Infraorbital Nerve Block for Cleft Lip Repair
To assess the efficacy of dexamethasone versus dexmedetomidine as adjuncts to bupivacaine for infra-orbital nerve block in infants undergoing cleft lip surgery.
- Trial name
- NCT03480607
- Testing
- Dexmedetomidine group, Dexamethasone group
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Mansoura University
Genital Warts, HPV
A RTC to Examine the Effectiveness of 400 mg of Oral Zinc Gluconate as Adjunctive Therapy for Ano-genital Warts
The purpose of this study is to examine the effect of 400 mg of oral zinc gluconate on genital warts. Our hypothesis is that there will be a 10% difference in complete clearance of genital warts in the group randomized to oral…
- Trial name
- NCT01468636
- Testing
- Oral Zinc
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Atrial Fibrillation, Intracerebral Hemorrhage
PREvention of STroke in Intracerebral haemorrhaGE Survivors With Atrial Fibrillation
Atrial fibrillation (AF) is the most common form of irregular heart rhythm. In people with AF, blood clots often form in the heart, which can travel to the brain.
- Trial name
- PRESTIGE-AF (NCT03996772)
- Testing
- Apixaban Oral Tablet, Dabigatran, Edoxaban Tablets
- Where
- 64 sites in Austria, France and 4 more
- Volunteers
- 319 people
- Sponsor
- Imperial College London
Behcet Disease and Vascular Involvement
Vascular Affection in Behcet Disease
To measure the level of serum elafin in patients with behcet disease and to assess the correlation between serum elafin and vascular affection and their relation with disease activity
- Trial name
- NCT06280430
- Volunteers
- 90 people
- Sponsor
- Assiut University
Multiple Sclerosis
Prospective Effectiveness and Safety Study of Cladribine in Participants Who Change First-line DMD Treatments for Multiple Sclerosis (CLAD CROSS)
The main aim was to study in the real world setting the effectiveness of Cladribine tablets in terms of Annualized Relapse Rate (ARR) and disability progression, in participants who switched from a first line Disease Modifying…
- Trial name
- NCT04934800
- Testing
- Cladribine
- Where
- 61 sites in Austria, Greece and 5 more
- Volunteers
- 256 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Myofacial Pain Syndrome
Dry Needling and Low-Level Laser Microcurrent Electrical Stimulation for Myofascial Pain Syndrome
This study aims to evaluate the effectiveness of dry needling and Low-Level Laser Microcurrent Electrical Stimulation (LL MCES) in patients with acute upper trapezius myofascial pain syndrome (MPS) by assessing both biological…
- Trial name
- NCT07750392
- Testing
- Dry Needle, Low-Level Laser Microcurrent Electrical Stimulation
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Udayana University
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