Clinical trials: Oral Cavity Disease, active
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma
Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
This phase II trial studies the effect of cemiplimab in combination with low-dose paclitaxel and carboplatin in treating patients with squamous cell carcinoma of the head and neck that has come back (recurrent) or spread to other…
- Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma, Metastatic Laryngeal Squamous Cell Carcinoma
- Trial name
- NCT04862650
- Testing
- Carboplatin, Cemiplimab, Paclitaxel
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Marcelo Bonomi
Carious Lesion, Ready-made Crowns
The Relation Between Oral Hygiene and Microbial Load in the Oral Cavity After Restoring Primary Molars With Two Types of Ready-made Crowns
Following the restoration of primary molars with stainless steel and bioflex crowns, an evaluation of the current state of oral hygiene in relation to the amount of microorganisms and gingival health in the oral cavity will be…
- Trial name
- bioflex crown (NCT06767670)
- Testing
- stainless steel crown, bioflex crown
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Peri-implantitis
Timing of Success Evaluation After Flapless Treatment of Peri-Implantitis
Peri-implantitis is an inflammatory disease around dental implants that causes progressive loss of the bone supporting the implant.
- Trial name
- NCT07844642
- Testing
- Flapless non-surgical treatment of peri-implantitis
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Barcelona
Bone Loss, Jaw, Edentulous
Effectiveness of 3D-printed Patient-specific Resorbable Scaffolds for Maxillary Bone Regeneration
The objective of this study is to test the bone formation capacity of a 3D printed scaffold with a plastic material called Polycaprolactone (PCL), compared to the use of synthetic bone grafts, for bone formation in the maxilla or…
- Conditions
- Bone Loss, Jaw, Edentulous, Edentulous Mouth, Jaw Fractures
- Trial name
- OSTEOPRINT (NCT06773923)
- Testing
- PCL Scaffold, PTFE + Bio-Oss®
- Where
- Chile
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Austral de Chile
Idiopathic Pulmonary Fibrosis
Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis
This is a Ph 2, randomized, double-blind, placebo-controlled global multicenter study to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of PIPE-791 in participants with a diagnosis of Idiopathic Pulmonary…
- Trial name
- NCT07284459
- Testing
- PIPE-791 Dose A, PIPE-791 Dose B
- Where
- 108 sites in Argentina, Australia and 17 more
- Volunteers
- 324 people
- Sponsor
- Contineum Therapeutics
Postherpetic Neuralgia, Peripheral Neuropathic Pain
Clinical Trial of the Safety and Efficacy of Peripheral Nerve Stimulation in the Treatment of Peripheral Neuropathic Pain.
The goal of this clinical trial is to evaluate safety and efficacy of percutaneous peripheral nerve stimulation in patients with peripheral neuropathic pain. The main questions it aims to answer are: 1.
- Conditions
- Postherpetic Neuralgia, Peripheral Neuropathic Pain, Trigeminal Neuralgia
- Trial name
- NCT06290661
- Testing
- Active electrostimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Peri-Implantitis, Plaque, Dental
Antibacterial Photodynamic Therapy in the Management of Peri-implantitis
This early-stage study is designed to determine the efficacy of the Lumoral method in periimplantitis. Improved supragingival plaque control can help to also sustain subgingival plaque management in the long term.
- Trial name
- NCT06017817
- Testing
- Lumoral Treatment, Standard oral hygiene instructions, Scaling and root planing (SRP
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Koite Health Oy
Meibomian Gland Dysfunction, Dry Eye Syndromes
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients
This observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07810569
- Volunteers
- 150 people
- Sponsor
- Assiut University
Edentulous Alveolar Ridge In Mandible, Complete Edentulism
Compare the Difference in Occlusal Force Distribution and Denture Retention Using 2 Different Denture Base Materials in Implant Retained Overdenture
The global increase in the aging population has led to a rise in total edentulism, which remains a major public health concern. two-implant-retained mandibular overdentures have been regarded as the standard of care, offering…
- Conditions
- Edentulous Alveolar Ridge In Mandible, Complete Edentulism, Dental Implant, Attachments
- Trial name
- NCT07250503
- Testing
- Conventional acrylic resin denture, Flexible resin denture
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Advanced Squamous Tumors
A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess safety, tolerability, pharmacokinetics and preliminary efficacy of ABBV-711 as a monotherapy…
- Trial name
- NCT07241039
- Testing
- ABBV-711, Budigalimab
- Where
- 13 sites in United States, Canada and 2 more
- Volunteers
- 220 people
- Sponsor
- AbbVie
Hand, Foot, and Mouth Disease (HFMD), Enterovirus 71 Infection
Bridging Clinical Trial of EV71 Vaccine in Vietnamese Children
The purpose of this study is to evaluate the immunogenicity and safety of an inactivated Enterovirus Type 71 (EV71) vaccine, manufactured by Sinovac, in healthy Vietnamese children aged 6 to 71 months.
- Trial name
- NCT07793175
- Testing
- EV71 vaccine
- Where
- Vietnam
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Periodontitis
Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis
The aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (APD) using Erythritol, Glycine, and Trehalose air-polishing powders in nonsurgical periodontal therapy with control…
- Trial name
- GBT (NCT06726902)
- Testing
- GBT and SI with erythritol powder, GBT and SI with glycine powder, GBT and SI with trehalose powder
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Diana Ibrahim
Periimplantitis, Periodontitis
Evaluation of the Effects of Routine Phase I Periodontal Therapy on Clinical Parameters and Levels of Gremlin-1, CTHRC1, and Tenascin-C in Gingival Crevicular Fluid and Peri-Implant Sulcular Fluid in Individuals With Periodontitis and Peri-Implantitis
The aim of this study is to compare the mechanisms of tissue destruction between natural teeth with periodontitis and implants with peri-implantitis within the same individual, and to evaluate the effects of routine Phase I…
- Trial name
- NCT07797127
- Testing
- Routine Phase I Non-Surgical Periodontal Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Adiyaman University
Burning Mouth Syndrome, Low Level Laser Therapy
Photobiomodulation Therapy vs. Alpha-Lipoic Acid in Burning Mouth Syndrome Treatment
The aim of this study was to evaluate the efficacy of photobiomodulation therapy and alpha-lipoic acid in the treatment of burning mouth syndrome by symptom assessment with visual analogue scale.
- Trial name
- NCT07381361
- Testing
- Low Level Laser Therapy, Alpha Lipoic Acid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Lu Jiang
Skin Disease, Immune System Disease
A Study of HL40626S Tablets in Healthy Adults
This is a single-centre, randomized, double-blind, placebo-controlled Phase 1 study to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of HL40626S tablets following single and…
- Conditions
- Skin Disease, Immune System Disease, Skin Diseases, Papulosquamous, Psoriasis (PsO)
- Trial name
- NCT07736586
- Testing
- HL40626S tablets
- Where
- 2 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- HighsLab Therapeutics Inc.
Complicated Urinary Tract Infection, Infection
Single Dose Intravenous Antibiotics for Complicated Urinary Tract Infections in Children
Urinary tract infections (UTI) are commonly encountered in children, with 7% diagnosed with at least one UTI by the age of 19 years.
- Conditions
- Complicated Urinary Tract Infection, Infection, Pediatric Infectious Disease
- Trial name
- CHOICE UTI (NCT04876131)
- Testing
- Benzylpenicillin - single dose, Benzylpenicillin - three days, Gentamicin - single dose
- Where
- 7 sites in Australia, New Zealand
- Volunteers
- 396 people
- Sponsor
- Murdoch Childrens Research Institute
Dental Plaque and Gingivitis, Oral Hygiene Reinforcement During Fixed Orthodontic Treatment
Mobile Application Push Notification in Improving Oral Hygiene Behaviour in Adolescent Orthodontic Patients
This research looks at whether using a mobile phone app that sends push-notification reminders can help adolescent orthodontic patients keep their teeth and gums cleaner during treatment.
- Trial name
- IMGS_EZGIGI (NCT07288853)
- Testing
- Ezgigi with push notification, EzGigi
- Where
- Malaysia
- Volunteers
- 78 people
- Sponsor
- Kumeran A/L Mohan
Mucositis, Peri Implant Mucositis
Effects of Enamel Matrix Derivative in the Treatment of Peri-implant Mucositis
To evaluate the naturally occurring peri-implant mucositis (PM) treatment by means of non-surgical sub-marginal peri-implant instrumentation (NSPI) with or without use of enamel matrix protein derivative (EMD).
- Trial name
- NCT06725095
- Testing
- Enamel Matrix Proteins Derivative
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Catania
Peri-implantitis
Electrolytic Surface Decontamination in the Surgical Treatment of Peri-implantitis: A Randomized Clinical Trial
The goal of this clinical trial is to learn whether adjunctive electrolytic surface decontamination can improve the outcomes of surgical treatment of peri-implantitis.
- Trial name
- NCT07644975
- Testing
- Electrolytic Surface Decontamination, Conventional Surgical Treatment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Wound Healing and Prevention, Oral Inflammation
Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva
The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation.
- Conditions
- Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management
- Trial name
- NCT07095556
- Testing
- Low-level laser therapy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
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