Clinical trials: Oral Complications
Malignancy, Non-hodgkin Lymphoma
A Phase 1/2 Study of CYT-0851 in B-Cell Malignancies and Advanced Solid Tumors
This clinical trial is an interventional, active-treatment, open-label, multi-center, Phase 1/2 study. The study objectives are to assess the safety, tolerability and pharmacokinetics (PK) of CYT-0851 in patients with…
- Conditions
- Malignancy, Non-hodgkin Lymphoma, Multiple Myeloma, Breast Cancer
- Trial name
- NCT03997968
- Testing
- CYT-0851, CYT-0851 in combination with gemcitabine, CYT-0851 in combination with capecitabine
- Where
- 16 sites in United States
- Volunteers
- 169 people
- Sponsor
- Cyteir Therapeutics, Inc.
Postoperative Pain, Facial Swelling
Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery
This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of…
- Conditions
- Postoperative Pain, Facial Swelling, Trismus
- Trial name
- Reparil (NCT07244029)
- Testing
- Escin, Ibuprofen 400 mg
- Where
- Oman
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oman Medical Speciality Board
Head and Neck Cancer, Radiation Therapy Complication
The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors
This study evaluates the possible benefits of a tasteless and sugar free chewing gum as a salivary stimulant for head and neck cancer patients treated with curative intended radiotherapy.
- Conditions
- Head and Neck Cancer, Radiation Therapy Complication, Xerostomia, Hyposalivation
- Trial name
- NCT03302676
- Testing
- Chewing gum
- Where
- Denmark
- Volunteers
- 109 people
- Sponsor
- Odense University Hospital
Surgical Site Infection, Anastomotic Leak
Oral Antibiotic Prophylaxis in Colorectal Surgery
The investigators perform a case-control study to compare preparation before elective colorectal surgery. The first group is a prospective patient - registry in all patients with mechanical bowel preparation (MBP) and oral…
- Trial name
- ABCR (NCT03759886)
- Testing
- Paromomycin Sulfate Powder
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Periapical Periodontitis, Root Canal Infection
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using EndoActivator for irrigation activation.
- Trial name
- NCT06339905
- Testing
- Sonic Activation with EndoActivator, Control Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Hyponatremias, Water Intoxication
"SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia
This study's purpose is to determine whether tolvaptan can safely and effectively return the body's balance of sodium and water toward normal, and to characterize and quantify the potential clinical benefits of this treatment.
- Conditions
- Hyponatremias, Water Intoxication, Inappropriate ADH Syndrome, Water-Electrolyte Imbalances
- Trial name
- NCT00072683
- Testing
- tolvaptan
- Where
- 23 sites in United States
- Volunteers
- 205 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Fallopian Tube Cancer, Ovarian Cancer
Docetaxel With or Without Phenoxodiol in Treating Patients With Recurrent Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00303888
- Testing
- docetaxel, idronoxil
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
This is an open-label study that will measure blood levels of different parts of a drug called GKS189075. People participating in this study will receive a single dose of 250mg GSK189075 by mouth.
- Conditions
- Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, Renal Insufficiency
- Trial name
- NCT00501462
- Testing
- GSK189075
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
PK, PD, and Safety
A Study Evaluating the Bioavailability of Oral Insulin (N11005)
The objective of this study was to preliminarily verify whether the oral insulin N11005 is a prandial insulin by assessing the PK, PD, and safety profiles of N11005.
- Trial name
- NCT04975022
- Testing
- N11005, Novolin R
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Beijing Hospital
Anastomotic Leak, Microbial Colonization
SURGIcal COmplication and MIcrobiome ChangeS in Colorectal Surgery
The microbiome, the collection of microorganisms that live in our gut, plays an important role in maintaining our health, proper nutrient absorption, nutrient turnover and immunity.
- Trial name
- Surgi-Comics (NCT05779254)
- Testing
- Neomycin Sulfate
- Where
- 3 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Uzsoki Hospital
Mucositis, Hematopoietic Stem Cell Transplantation
Effects of Mesenchymal Stem Cell Supernatant on Prevention and Treatment of Skin/Mucosal Injury in Hematology Patients
This clinical trial is studying the effects of mesenchymal stem cell (MSC) culture supernatant on the prevention and treatment of mucosal injuries in patients undergoing hematopoietic stem cell transplantation (HSCT).
- Conditions
- Mucositis, Hematopoietic Stem Cell Transplantation, Chemotherapy-Induced Mucositis, Radiation-Induced Mucositis
- Trial name
- MSC-MucInj (NCT06599346)
- Testing
- Standard Care, MSC Supernatant + Standard Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The General Hospital of Western Theater Command
Obstetric Labour, Premature
The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor
Pre-Term Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor.
- Trial name
- NCT00404768
- Testing
- GSK221149A
- Where
- 57 sites in United States, Argentina and 9 more
- Volunteers
- 93 people
- Sponsor
- GlaxoSmithKline
Preterm Birth, Periodontal Disease
Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi
The hypothesis of the investigators' project is that comprehensive primary preterm birth prevention, inclusive of maternal oral health with xylitol chewing gum (the intervention), will reduce the rate of periodontal disease and…
- Conditions
- Preterm Birth, Periodontal Disease, Caries, Dental
- Trial name
- PPaX (NCT02333227)
- Testing
- Xylitol gum
- Where
- United States
- Volunteers
- 10,069 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Premature
Oral Motor Intervention to Preterms by Their Mothers
Babies who have been discharged from the neonatal intensive care unit and have difficulty in oral feeding will be identified. Oral Motor Intervention (PIOMI) will be taught to the mothers of these babies and asked to practice.
- Trial name
- NCT06194513
- Testing
- Intervention 1: Twice a day for 1 week PIOMI, Intervention 2: Once a day for 2 weeks PIOMI
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Marmara University
Pre-eclampsia, Fetus or Newborn; Effects of Induction of Labor
Induction With Foley OR Misoprostol (INFORM) Study
Between 40,000 and 80,000 pregnant women die annually from pre-eclampsia and eclampsia. Magnesium sulphate and anti-hypertensive therapies can reduce the morbidity associated with pre-eclampsia.
- Trial name
- INFORM (NCT01801410)
- Testing
- Foley Catheter, Misoprostol
- Where
- 2 sites in India
- Volunteers
- 602 people
- Sponsor
- University of Liverpool
Type 2 Diabetes Mellitus, Periodontitis
Oral Health Policy for Patients With Type 2 Diabetes Mellitus in Chile: A Microsimulation Model Based on Real-world Data
The goal of this study is to evaluate the cost-effectiveness of the current proposal and different decision-making scenarios of periodontal care coverage increases for patients with T2DM in Chile.
- Conditions
- Type 2 Diabetes Mellitus, Periodontitis, Diabetic Complication, Dental Care
- Trial name
- NCT05809817
- Testing
- Periodontal treatment
- Where
- 2 sites in Chile
- Volunteers
- 135 people
- Sponsor
- University of Chile
Atrial Fibrillation, End-stage Kidney Disease
Compare Apixaban and Vitamin-K Antagonists in Patients With Atrial Fibrillation (AF) and End-Stage Kidney Disease (ESKD)
The Study is an open-labeled, randomized controlled trial, phase IIIb. Its objective is to assess the safety of the factor Xa inhibitor apixaban versus the vitamin-K antagonist (VKA) phenprocoumon in patients with NVAF and ESKD…
- Trial name
- AXADIA (NCT02933697)
- Testing
- Apixaban, Phenprocoumon
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Atrial Fibrillation Network
Premature, Nutrition Disorders
Comparison of the Effects of Oral Stimulation and Non-nutritive Sucking Practices
This study, it was aimed to compare the effects of oral stimulation and non-nutritive sucking practices on the transition to full oral feeding in babies with a gestational age of 26-32 weeks.
- Conditions
- Premature, Nutrition Disorders, Sucking Behavior
- Trial name
- NCT05249179
- Testing
- Pacifier, Oral stimulation
- Volunteers
- 140 people
- Sponsor
- Ankara City Hospital Bilkent
HIV Infections, Pregnancy
The Safety and Effectiveness of Zidovudine in HIV-Infected Pregnant Women and Their Infants
To determine whether the rate of HIV transmission from mother to infant can be reduced by continuous oral zidovudine (AZT) treatment to HIV infected pregnant women, intravenous AZT during childbirth, and oral AZT treatment of the…
- Trial name
- NCT00000960
- Testing
- Zidovudine
- Where
- 62 sites in United States, Puerto Rico
- Volunteers
- 1,496 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetic Nephropathies
This International Study Tests BI 690517 in Patients With Diabetic Kidney Disease. The Study Tests How 3 Different Doses of BI 690517 Are Taken up in the Body and How Well They Are Tolerated
The primary objective of this current trial is to investigate the safety and tolerability of 3 oral doses of BI 690517 over 28 days in female and male patients with diabetic nephropathy as add-on-therapy to Angiotensin Converting…
- Trial name
- NCT03165240
- Testing
- BI 690517, Eplerenone
- Where
- 40 sites in Denmark, France and 8 more
- Volunteers
- 62 people
- Sponsor
- Boehringer Ingelheim