Clinical trials: Oral Health
Gingivitis
Powered Toothbrush Versus Manual Toothbrush on Plaque and Gingivitis After a Six-Week Period of Home Use
The goal of this clinical trial is to learn if powered toothbrushing is more effective than manual toothbrushing in removing dental plaque. It will also learn about the safety of power toothbrushing.
- Trial name
- NCT07691814
- Testing
- power toothbrush, manual toothbrush
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Chronic Periodontitis
Efficacy of a Probiotic Lozenge (Inersan) in Patients With Chronic Periodontitis
Periodontal disease is a major cause of tooth loss in humans and is one of the most prevalent diseases associated with bone loss.
- Trial name
- NCT01870362
- Testing
- Probiotic (Inersan)
- Where
- India
- Volunteers
- 28 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Dental Plaque, Gingivitis
A Clinical Study to Evaluate the Efficacy of a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation
The aim of this 12-week clinical study is to evaluate the ability of an experimental mouthwash, containing 0.085 percent (%) Cetylpyridinium chloride (CPC) as an adjunct to toothbrushing with a regular fluoride toothpaste, to…
- Trial name
- NCT06933368
- Testing
- Crest Cavity Protection Toothpaste, Experimental Mouthwash
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- HALEON
Vaginal Health
A Trial to Assess the Pharmacokinetics and Pharmacodynamics of a Novel Synbiotic Oral Supplement for Vaginal Health
A randomized, placebo-controlled trial to assess the Pharmacokinetics and Pharmacodynamics of a novel synbiotic dietary supplement for vaginal health.
- Trial name
- NCT07435350
- Testing
- Vaginal Health Active VV-01
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Oral Health
Effect of an Oral Probiotic Tablet on Oral Bacteria and Clinical Measurements (ProBiora3)
The purpose of this study is to determine if an oral probiotic tablet taken once a day for twelve weeks can decrease the numbers of bacteria that are associated with tooth decay and gum disease in a dentally healthy, young adult…
- Trial name
- NCT01520974
- Testing
- ProBiora3 mints
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Oragenics, Inc.
Gingivitis
A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers
The purpose of this study is to investigate the effectiveness of usage of a range of oral products (toothpaste, mouth rinse, denture cleanser) on the oral health of partial denture wearers compared to existing oral hygiene…
- Trial name
- NCT04290624
- Testing
- Experimental Dentifrice: Stannous Fluoride, COREGA Denture Foaming Cleanser, Mouth rinse: Sodium Fluoride
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- HALEON
Tobacco Dependence
Bioequivalence Between Two Oral Nicotine Sublingual Tablets, 2 mg and 4 mg
The purpose of this study is to assess the bioequivalence between two oral nicotine sublingual tablets, 2 mg and 4 mg.
- Trial name
- NCT01238627
- Testing
- Nicotine Sublingual Tablet Mint (NSTM), Marketed Nicotine Tablet
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- McNeil AB
Skin Health
The Influence of Probiotics in a Drinkable Yogurt on Skin Health
The aim of this study is to test if probiotics administered to healthy female subjects in a dairy format have any skin health benefits.
- Trial name
- NCT00864188
- Testing
- no bacterial strains, One probiotic strain - Lactobacillus paracasei NCC2461, Two standard yogurt fermenting bacterial strains - Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus
- Where
- Germany
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Oral Health, Intellectual Disability
Supervised Brushing Programme for Intellectual Disabled Students
Intellectual disabled persons faced more dental problems. According to a medical review paper of international and local studies, this group has poorer dental hygiene, more severe gum disease and more untreated caries.
- Conditions
- Oral Health, Intellectual Disability, Randomized Controlled Trial
- Trial name
- NCT03234231
- Testing
- 3-month supervised tooth brushing programme, oral health education talk
- Volunteers
- 602 people
- Sponsor
- MD Equation
Oral Health
Effect of Two Toothpastes on Bacteria in Saliva
This study investigated the ability of two zinc-containing toothpaste formulations (Zinc A and Zinc B) to reduce the level of bacteria in saliva in the two-hour period after their use, compared to the effect of rinsing with water…
- Trial name
- NCT03587428
- Testing
- Zinc-A toothpaste, Zinc-B toothpaste, Mineral water
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Orthodontic Appliance Complication, Plaque, Dental
Regular Home Use of Dual-light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment
This study is designed to determine the efficacy of the Lumoral method on oral health in adolescents undergoing fixed orthodontic treatment.
- Conditions
- Orthodontic Appliance Complication, Plaque, Dental, Gingival Inflammation
- Trial name
- NCT05825742
- Testing
- Lumoral Treatment, Standard oral health instructions
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Norovirus Infections
Ph 1b: Safety & Immunogenicity of Ad5 Based Oral Norovirus Vaccine
A Phase 1b, multicenter, randomized, double-blind, placebo-controlled study to determine the safety and immunogenicity of an adenoviral-vector based oral norovirus vaccine expressing GI.1 VP1 administered orally to healthy older…
- Trial name
- VXA-NVV-104 (NCT04854746)
- Testing
- VXA-GI.1.NN
- Where
- 3 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Vaxart
Smoking Cessation
Provoked Craving Relief Study by NRT
This study is designed to assess the ability of the mint nicotine mouth strip to relieve provoked cigarette craving in light smokers compared to nicotine lozenge and nicotine gum.
- Trial name
- NRT (NCT01476202)
- Testing
- nicotine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
End Stage Renal Disease
Health Effects of oraL Protein Supplements in HD (The HELPS-HD Trial)
To conduct a pragmatic randomized clinical trial in which the researchers will determine the mortality impact of a protocol whereby all hemodialysis patients receive an oral, protein-based nutritional supplement during the…
- Trial name
- HELPS-HD (NCT02933151)
- Testing
- Nutritional Supplement
- Where
- 2 sites in United States
- Volunteers
- 10,457 people
- Sponsor
- Dialysis Clinic, Inc.
Obesity, Overweight
A Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight and Weight-Related Health Problems
The purpose of this study is to learn how well orforglipron works and how safe it is in Chinese adults with obesity or overweight and related health problems. Participation in this study will last about 53 weeks (about 1 year).
- Trial name
- ATTAIN-CN (NCT07790861)
- Testing
- Orforglipron
- Where
- 13 sites in China
- Volunteers
- 192 people
- Sponsor
- Eli Lilly and Company
Health Postmenopausal Women
Drug Interaction of SMC021 With Concomitant Antacid (Calcium Carbonate/Magnesium Hydroxide).
This study will assess the effect of concomitant antacid on the pharmacokinetics and pharmacodynamics of SMC021
- Trial name
- NCT00421590
- Testing
- SMC021
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Novartis
Pharmacokinetics, Bioavailability
An Investigation Of The Effects Of Food On The Absorption Of A Varenicline Controlled Release Formulation
1. To estimate the absorption of a single oral dose of a controlled release varenicline tablet under fed and fasted conditions. 2.
- Conditions
- Pharmacokinetics, Bioavailability, Smoking Cessation
- Trial name
- NCT00731562
- Testing
- Varenicline Tartrate Controlled Release
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Gingivitis
Efficacy of the Addition of a Power Interdental Device to an Electric Toothbrush on Gingival Health.
The study is designed to evaluate the clinical changes in gingival health by measuring the reduction of gingival bleeding and inflammation over 4 weeks.
- Trial name
- NCT04003298
- Testing
- Electric toothbrush, Control
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Water Pik, Inc.
Tobacco Use Cessation
Study Evaluating The Efficacy Of Varenicline In Cessation Of Oral Smokeless Tobacco Use
The primary goal of this study is to compare efficacy of varenicline to placebo for cessation of use of smokeless tobacco.
- Trial name
- NCT00717093
- Testing
- Varenicline Tartrate
- Where
- 16 sites in Norway, Sweden
- Volunteers
- 432 people
- Sponsor
- Pfizer
Schizophrenia
A Study to Detect the Radioactivity of 14C-SEP-380135 in Urine and Feces in Healthy Male Adults
The purpose of the present trial is to obtain information on the absorption, distribution, metabolism, excretion and pharmacokinetics (PK) of 14C-SEP-380135 and its metabolites following a single oral dose.
- Trial name
- NCT07455084
- Testing
- 14C-SEP-380135
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.