Clinical trials: Oral Health
Infections, Rotavirus
Safety Study of GSK Biologicals' Rotavirus Vaccine (Rotarix®) Administered to Children Aged <1 Year in the United States
This observational cohort study, conducted through two existing large administrative health databases in the US (outside the Vaccine Safety Datalink) is planned to confirm the safety profile regarding lack of any association of…
- Trial name
- NCT00875641
- Testing
- Health Insurance Database
- Where
- United States
- Volunteers
- 390,659 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tobacco Dependence
Bioequivalence Between Two New Oral Nicotine Replacement Therapy Products and Nicorette® Microtab
The purpose of this study is to assess the bioequivalence between two new oral nicotine replacement therapy products and Nicorette® microtab.
- Trial name
- NCT01238640
- Testing
- Code STD, Code STE, Nicorette Microtab
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- McNeil AB
Atrial Fibrillation
Adherence to New Oral Anticoagulation Therapy in Turkey
This study will compose a national database of drug adherence and investigate the factors that affect drug adherence in patients taking new oral anticoagulation therapy in Turkish Population.
- Trial name
- NOAC-TR (NCT02480920)
- Where
- Turkey (Türkiye)
- Volunteers
- 2,738 people
- Sponsor
- Cardiovascular Academy Society, Turkey
Quality of Life, Cervical Abrasion
The Role of Biodentine in Class V Dental Lesions on Oral Health Related Quality of Life
The study will compare two different dental materials on dental lesions near the gum line that cause chronic pain on oral health related quality of life.
- Trial name
- NCT03304184
- Testing
- Photac-fil, Biodentine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Periodontitis
Periodontal Infection and Endothelial Dysfunction
The purpose of this study is to determine the effect of periodontal therapy on endothelial function and other biomarkers of cardiovascular disease
- Trial name
- NCT00681564
- Testing
- One-Stage Full-Mouth Disinfection, Periodontal care
- Where
- 2 sites in Colombia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Caries, Dental, Health Behavior
Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children
This is a randomized clinical trial to test the efficacy of a parent-targeted text message-based intervention program on caries incidence and oral health behaviors (child and parent).
- Trial name
- iSmile (NCT03294590)
- Testing
- OHT Parent targeted text messages, CWT Parent targeted text messages
- Where
- United States
- Volunteers
- 754 people, healthy volunteers welcome
- Sponsor
- Boston University
Healthy
Factors Controlling the Formation of Salivary Films
The aim of this study is to determine how different ingredients which are found in food and other consumer products affect the ability of saliva to form surface films.
- Trial name
- SalFilm (NCT01167504)
- Testing
- Saliva sample collection
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Aging, Long-Term Care
Oral Hygiene in Assisted Living
This project will modify a program that reduces pneumonia among nursing home residents with dementia, so that it is appropriate for assisted living residents with dementia.
- Trial name
- NCT03892200
- Testing
- Aim2 - Daily Mouth Care, Aim3 - Daily Mouth Care
- Where
- United States
- Volunteers
- 1,405 people
- Sponsor
- University of North Carolina, Chapel Hill
Denture Retention
To Evaluate Oral Health and Quality of Life Associated With Use of a Denture Adhesive
The aim of this study is to evaluate the use of a denture adhesive and its ability to demonstrate the improvement in overall gum-health and to improve the oral health related quality of life (OHrQoL) in participants who wear full…
- Trial name
- NCT03807700
- Testing
- Experimental Denture Adhesive
- Where
- Canada
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Adherence to Medication Regime, Cancer
Mobile Application for Improving Symptoms and Adherence to Oral Chemotherapy in Patients With Cancer
Many people treated for cancer receive oral chemotherapy medications for their illness. This means that much of their cancer care occurs at home, away from a traditional oncology care setting.
- Trial name
- NCT02157519
- Testing
- Mobile Application Intervention
- Where
- 3 sites in United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Oral Health
A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome
The aim of this study is to evaluate the effect of a toothpaste containing stannous fluoride (SnF2) over time on the oral bacterial composition and activity and to explore its effect in comparison to a regular fluoride toothpaste.
- Trial name
- NCT06048809
- Testing
- Stannous Fluoride Toothpaste (Sensodyne Repair and Protect), Regular Fluoride Toothpaste (Colgate Cavity Protection)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Plaque, Gingivitis
The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US
The objective of this clinical research study is to evaluate clinical efficacy of Colgate Total Toothpaste as compared to Crest Pro-Health Toothpaste and Crest Pro-Health Mouthwash, and Crest Cavity Protection Toothpaste and…
- Trial name
- NCT02360995
- Testing
- Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride toothpaste
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
End Stage Renal Disease
Health Effects of oraL Protein Supplements in HD (The HELPS-HD Trial)
To conduct a pragmatic randomized clinical trial in which the researchers will determine the mortality impact of a protocol whereby all hemodialysis patients receive an oral, protein-based nutritional supplement during the…
- Trial name
- HELPS-HD (NCT02933151)
- Testing
- Nutritional Supplement
- Where
- 2 sites in United States
- Volunteers
- 10,457 people
- Sponsor
- Dialysis Clinic, Inc.
Fluoride Varnish and Oral Health Promotion, Usual Care
Preventing Caries in Preschoolers: Testing a Unique Service Delivery Model in American Indian Head Start Programs
An intensive intervention of specially trained paraprofessionals, called community oral health specialists (COHS), administering on a quarterly basis for 2 years fluoride varnish and oral health promotion education, compared to…
- Trial name
- NCT01116739
- Testing
- Fluoride varnish, Oral health education, Dental services delivered by the Indian Health Service.
- Where
- United States
- Volunteers
- 2,060 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Neoplasms
Smart-phone Application to Promote Medication Adherence in Adolescents and Young Adults (AYA) With Cancer
To explore use of a smart-phone medication reminder application to promote adherence to oral medications by AYA with cancer.
- Trial name
- NCT01618344
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Utah
Periodontal Diseases, Chronic Periodontitis
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status…
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket, Tooth Mobility
- Trial name
- NCT03364751
- Testing
- IQOS, Cigarette
- Where
- 26 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Philip Morris Products S.A.
Bladder Cancer, Cervical Cancer
Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking
RATIONALE: A stop-smoking plan that includes health education counseling and bupropion may help African-American smokers stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00666978
- Testing
- smoking cessation intervention, bupropion hydrochloride, gene expression analysis
- Where
- 2 sites in United States
- Volunteers
- 540 people
- Sponsor
- Lisa Sanderson Cox, PhD
Dental Plaque
Evaluating the Effect of Tooth Cleaning Devices on Oral Health
This is a study to evaluate the safety and the efficacy of tooth and interproximal cleaning modalities on oral health.
- Trial name
- NCT01250769
- Testing
- Manual Toothbrush, Interproximal Cleaning Device
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Philips Oral Healthcare
Obesity, Insulin Resistance
Vitamin D Supplementation to Obese Chinese Males
Hypothesis: Oral Supplementation of Vitamin D can Reduce Hypersecretion of Parathyroid Hormone and Insulin Resistance in Obese Chinese Males.
- Trial name
- NCT01781169
- Testing
- Oral supplementation of vitamin D
- Where
- China
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Tobacco Dependence
Single-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product
A comparison of three products for oral nicotine replacement with respect to pharmacokinetics after single-dose of nicotine.
- Trial name
- NCT01084603
- Testing
- Oral Nicotine, NiQuitinTM Nicotine Lozenge, Nicorette® Nicotine Gum
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- McNeil AB