Clinical trials: Oral Leukoplakia, active
Erythroplakia, Oral Leukoplakia
Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia
This phase IIb trial tests whether metformin works in preventing oral cancer in patients with oral leukoplakia (white patches) or erythroplakia (red patches). Metformin is in a class of drugs called biguanides.
- Trial name
- NCT05237960
- Testing
- Biopsy, Biospecimen Collection, Extended Release Metformin Hydrochloride
- Where
- 10 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- University of Arizona
Oral Dysplasia, Leukoplakia Oral
Topical Imiquimod Treatment of Oral Dysplasia
The goal of this clinical trial is to determine the effectiveness of imiquimod in treating oral dysplasia in adult patients. Imiquimod 5% cream could be a safe and practical treatment for oral epithelial dysplasia (a precancerous…
- Conditions
- Oral Dysplasia, Leukoplakia Oral, Leukoplakia
- Trial name
- NCT07210775
- Testing
- Imiquimod (topical use)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Oral Leukoplakia
Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia
The goal of this clinical trial is to learn if calcipotriol and photodynamic therapy are equally effective in treatment of leukoplakia or not.
- Trial name
- NCT07658508
- Testing
- Calcipotriol 0.005% gel, ALA mediated PDT
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Oral Leukoplakia
Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia
This is a Phase IIa oral cavity leukoplakia study of pioglitazone 15mg and metformin 500mg BID for 12 weeks. The primary objective is to determine the clinical and histologic changes of leukoplakia from baseline following a 12…
- Trial name
- NCT05727761
- Testing
- pioglitazone-metformin
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Mouth Diseases
Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™
The purpose of this study is to validate the ability of the STRATICYTE™ predictive model to predict the transformation of oral potentially malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC) in a retrospective…
- Trial name
- NCT05853783
- Testing
- STRATICYTE™ Test
- Where
- 5 sites in United States
- Volunteers
- 180 people
- Sponsor
- Proteocyte Diagnostics Inc.
Erythroplakia, Fanconi Anemia
Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer
This clinical trial studies widefield fluorescence and reflectance imaging, fluorescence spectroscopy, and tissue samples in regularly examining (monitoring) participants at risk for developing oral cancer.
- Conditions
- Erythroplakia, Fanconi Anemia, Lichen Planus, Oral Cavity and Lip Precancerous Condition
- Trial name
- NCT00542373
- Testing
- Cytology Specimen Collection Procedure, Diagnostic Microscopy, Diagnostic Procedure
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- M.D. Anderson Cancer Center
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography
This clinical trial aims to assess the efficacy of Optical Coherence Tomography (OCT) in the early diagnosis of oral cancer. It focuses on Oral Potentially Malignant Disorders (OPMDs) as precursors to Oral Squamous Cell Carcinoma…
- Conditions
- Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder, Oral Leukoplakia, Proliferative Verrucous Leukoplakia
- Trial name
- SYMILIS OCT (NCT06321003)
- Testing
- OCT (Optical Coherence Tomography)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Palermo
Oral Leukoplakia
Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia
There is no consensus on treatment of leukoplakia but surgical excision is the preferred choice if suitable in size, which does not prevent clinical recurrence and malignant transformation.
- Trial name
- NCT07387900
- Testing
- Metformin Hydrochloride
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Oral Leukoplakia, Oral Leukoplakia of Tongue
Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore
Oral squamous cell carcinomas (OSCC) is among the most common malignancies worldwide. Early detection and prevention of OSCC is thought to have the highest potential to reduce morbidity and mortality.
- Conditions
- Oral Leukoplakia, Oral Leukoplakia of Tongue, Oral Leukoplakia of Gingiva, Oral Lichen Planus
- Trial name
- PREDICT-OLP (NCT03975322)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
The Importance of Mucosal Screening in the Prevention of Oral Cancer.
Patients attending the Department of Oral Mucosal and Periodontal Diseases at the University Dental Center of the Medical University of Warsaw who provide written informed consent will be invited to participate in the study.
- Conditions
- OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Potentially Malignant Lesions, Leukoplakia Oral
- Trial name
- NCT07682883
- Testing
- Fluorescent oral examination (FOE), Conventional oral examination
- Where
- Poland
- Volunteers
- 1,383 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Erythroleukoplakia, Leukoplakia
Pembrolizumab in Treating Participants With Leukoplakia
This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.
- Conditions
- Erythroleukoplakia, Leukoplakia, Verrucous Oral Leukoplakia
- Trial name
- NCT03603223
- Testing
- Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Oral Lichen Planus, Oral Leukoplakia
Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders
Oral potentially malignant disorders (OPMDs) are mucosal lesions that carry a risk of malignant transformation into oral cancer.
- Conditions
- Oral Lichen Planus, Oral Leukoplakia, Traumatic Ulcer of Oral Mucosa, Erythroleukoplakia of Mouth
- Trial name
- NCT07318922
- Testing
- Toluidine blue staining of the lesion and cytological smears
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Oral Leukoplakia
Comparison of Topical Photodynamic Therapy With Topical Calcipotriol in Management of Oral Leukoplakia
(i)Rationale/ gaps in existing knowledge,: Oral cancer, one of the top three common cancers in India is usually preceded by Oral potentially malignant disorders in nearly two thirds of the cases like Oral leukoplakia.
- Trial name
- PDT CALCI HOL (NCT07453472)
- Testing
- Non-invasive Photo Dynamic Therapy using LED of wavelength ranging from 630-660nm( Fluence 15 J/cm2) as light source and 2.5% TB as photosensitizer, Topical application of Calcipotriol ointment 0.005% twice a day for 4 weeks along with preventive and conventional therapy, Conventional non-invasive management : All subjects in the two groups will receive the same standard conventional non- invasive management advised for OL as per current scientific evidence
- Where
- India
- Volunteers
- 166 people
- Sponsor
- Dr. Shalini Gupta
Oral Potentially Malignant Disorders, Oral Lichen Planus
Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers
The goal of this observational study is to learn whether two inflammatory proteins, interleukin-8 (IL-8) measured in saliva and interleukin-6 (IL-6) measured in blood serum, can help distinguish adults with oral potentially…
- Conditions
- Oral Potentially Malignant Disorders, Oral Lichen Planus, Oral Leukoplakia, Oral Squamous Cell Carcinoma
- Trial name
- NCT07915570
- Testing
- Salivary IL-8 and Serum IL-6 Measurement
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Oral Cancer, Oral Cavity Cancer
Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions
The primary goal of this study is to see if photodynamic therapy (PDT) is effective for treatment of lesions in the oral cavity which have high risk of becoming oral cancer.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Oral Leukoplakia, Oral Lichen Planus
- Trial name
- NCT06876038
- Testing
- 5-Amino Levulinic Acid
- Where
- 2 sites in India
- Volunteers
- 65 people
- Sponsor
- University of Massachusetts, Boston
Oral Leukoplakia
Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment
Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role.
- Trial name
- NCT07331935
- Testing
- Coenzyme Q10 gel, Topical curcumin gel
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Alexandria University
Oral Neoplasm
Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment
The purpose of this observational study is to evaluate the utility of the S100A7 immunohistochemistry signature-based assessment - STRATICYTE - in determining the risk of progression to cancer of clinically suspicious oral…
- Trial name
- NCT04622462
- Testing
- Standard of Care Histopathology, STRATICYTE Assessment
- Where
- 3 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Proteocyte Diagnostics Inc.
Mouth Neoplasms
Oral Cancer Screening for Early Detection of Premalignant Disorders (PMOD)
Cancer is a complex disease; its different causes and types have a strong impact on patient treatment and prognosis. To improve understanding of the disease, its causes and progression, the investigators will develop a simple…
- Trial name
- PMOD (NCT05296941)
- Testing
- Brush sampling
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Erythroplakia, Hyperplasia
Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
This phase IIa trial studies how well metformin hydrochloride works in preventing oral cancer in patients with an oral premalignant lesion (oral leukoplakia or erythroplakia).
- Conditions
- Erythroplakia, Hyperplasia, Oral Cavity Carcinoma, Oral Leukoplakia
- Trial name
- NCT02581137
- Testing
- Laboratory Biomarker Analysis, Metformin Hydrochloride
- Where
- 4 sites in United States, Canada
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)