Clinical trials: Oral Lichen Planus
Oral Lichen Planus
The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus
The aim of the present study is to assess the clinical efficacy of topical minocyclin in managing of symptoms associated with oral lichen planus (OLP).
- Trial name
- NCT01083420
- Testing
- Minocycline, Dexamethasone
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Oral Lichen Planus
Efficacy of Ginger Muco-bioadhesive Gel in Management of Oral Lichen Planus With Immunohistochemical Analysis
1. Compare the clinical efficacy of topical ginger extract versus triamcinolone acetonide 0.1% for symptomatic oral lichen planus (Primary Objective). 2.
- Trial name
- NCT05882864
- Testing
- 6-Gingerol, Triamcinolone Acetonide 0.1% Oromucosal Paste
- Volunteers
- 28 people
- Sponsor
- Ain Shams University
Lichen Planus, Oral, Low-Level Light Therapy
Photobiomodulation in Oral Lichen Planus
The aim of this study was to compare the efficacy of PBM (660nm) and corticosteroid therapy with clobetasol propionate 0.05% in the treatment of OLP. This is a protocol for a randomized, controlled, double blind clinical trial.
- Trial name
- NCT03320460
- Testing
- Propionate clobetasol gel 0.05%, Photobiomodulation
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Nove de Julho
Oral Lichen Planus
Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus
60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing Quantitative real-time polymerase chain…
- Trial name
- NCT02834520
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus, Oral Lichen Planus Related Stress
Evaluating Treatment Efficacy in Oral Lichen Planus: The Role of Salivary Biomarkers
Lichen planus, a chronic autoimmune mucocutaneous disorder, affects 0.5% to 2.2% of diverse populations. The treatment for oral lichen planus (OLP) includes a range of options, both topical and systemic therapies.
- Trial name
- salivaLichen (NCT06332365)
- Testing
- Acetonide triamcinolone 0.2% +hyaluronicacid 1%, Corticoid Acetonide triamcinolone 0.2%, Hyaluronic acid 1%
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Pia Lopez Jornet
Oral Lichen Planus
Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus
The study included forty individuals divided into 3 groups. 10 control subjects, 15 oral lichen planus (OLP) patients who were treated with topical corticosteroids and 15 oral lichen planus (OLP) patients who were treated with…
- Trial name
- NCT02329600
- Testing
- green tea tablets (Green tea extract 5:1) 200 mg, Triamcinolone Acetonide
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus, Topical Sulfasalazine
Topical Sulfasalazine and Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucosal membrane. T-cell mediated damage against the mucosal epithelial cells is implicated in the pathogenesis of OLP, although the exact mechanism is…
- Conditions
- Oral Lichen Planus, Topical Sulfasalazine, Corticosteroids
- Trial name
- NCT06060301
- Testing
- sulfasalazine 500 MG, corticosteroids
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University
Lichen Planopilaris, Frontal Fibrosing Alopecia
Oral Low-Dose Naltrexone for Lichen Planopilaris and Frontal Fibrosing Alopecia
Oral naltrexone was initially FDA approved to treat opioid use disorder and alcohol dependence at doses from 50-100mg/day. At lower doses of 1-5mg/day, naltrexone has been used off-label with success in treatment of several…
- Trial name
- NCT04409041
- Testing
- Low-Dose Naltrexone
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Oral Lichen Planus
Efficacy of Topical Glucosamine Versus Corticosteroid in Oral Lichen Planus
Glucosamine (GlcN) is an N-deacetyl amino sugar derived from the complete hydrolysis of chitosan. It is classified as a nutraceutical and it is used mainly orally for the therapy of osteoarthritis since GlcN has immunoregulatory…
- Trial name
- NCT07114016
- Testing
- Glucosamine Hydrochloride, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Future University in Egypt
Oral Leukoplakia, Oral Lichen Planus
Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy
Abstract Objective: To study the diagnostic efficiency of Rose Bengal with Toluidine blue in detecting the biopsy sites and thus establish an accurate diagnosis in oral premalignant lesions.
- Conditions
- Oral Leukoplakia, Oral Lichen Planus, Premalignant Lesion
- Trial name
- NCT03031899
- Testing
- Biopsy, Rose Bengal, toluidine blue
- Volunteers
- 27 people
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Oral Lichen Planus
Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus
Glucosamine (GlcN) is an N-deacetyl amino sugar derived from the complete hydrolysis of chitosan with recently reported immunoregulatory capacity and anti-inflammatory effect and was administrated orally in osteoarthritis and…
- Trial name
- NCT02858297
- Testing
- Glucosamine sulfate, triamcinolone acetonide
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model
This study aims to improve how oral mucosal disorders-such as oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, herpes viral infection and oral candidiasis-are treated in dental settings.
- Conditions
- Oral Lichen Planus, Recurrent Aphthous Stomatitis, Burning Mouth Syndrome, Oral Candidiasis
- Trial name
- NCT07721090
- Testing
- Pharmacist-Led Prescribing Optimization and Patient Counselling
- Volunteers
- 336 people
- Sponsor
- University of Fujairah
Oral Lichen Planus, Vitamin D Deficiency
Vitamin D Deficiency As a Risk Factor for the Development and Malignant Transformation of Oral Lichen Planus
To examine how a lack of vitamin D may increase the risk of developing oral lichen planus and its malignant progression while accounting for sex, food habits, sunlight, socioeconomic level, and psychological variables.
- Trial name
- NCT06033105
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Oral Lichen Planus
Tacrolimus Ointment in Oral Lichen Planus
The purpose of this study is to compare the effectiveness of topical tacrolimus, triamcinolone and placebo in alleviating signs and symptoms of oral lichen planus (OLP).
- Trial name
- NCT01544842
- Testing
- 0.1 % tacrolimus ointment, 0.1 % triamcinolone paste, Orabase paste
- Where
- 2 sites in Finland
- Volunteers
- 28 people
- Sponsor
- University of Oulu
Lichen Planus
Systemic Treatment Options for Generalized Lichen Planus
Lichen planus is a chronic inflammatory skin condition with unknown etiology. It requires a long term treatment. Evaulating the most efficacious, safe and affordable treatment option is the need of the hour.
- Trial name
- NCT06739551
- Testing
- Methotrexate (drug), Acitretin
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Sheikh Zayed Medical College
Oral Lichen Planus
Dexamethasone to Treat Oral Lichen Planus
This study will evaluate the effectiveness of dexamethasone 0.01% solution in treating pain associated with oral lichen planus, a chronic disease that causes painful ulcers inside the mouth.
- Trial name
- NCT00111072
- Testing
- dexamethasone 0.01% solution
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Oral Lichen Planus
Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus
Oral lichen planus (OLP) is a chronic disease characterized by periods of remission and relapse. Therapeutic objectives for OLP should be to quickly reduce disease symptoms by targeting pathophysiological pathways, and to provide…
- Trial name
- NCT02443311
- Testing
- Pimecrolimus 1% cream, Betamethasone 17-valerate 0.1% cream
- Volunteers
- 24 people
- Sponsor
- Ain Shams University
Oral Lichen Planus, Thyroid Disease
Association Between Oral Lichen Planus and Thyroid Disease
The goal of this observational study is to determine the prevalence of thyroid disease in adults with oral lichen planus (OLP) treated at the Dental Hospital of the University of Barcelona (HOUB), and to evaluate the association…
- Trial name
- NCT06550154
- Testing
- Data collection
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Oral Erosive Lichen Planus
Evaluation of the Efficacy of 0.08% Tacrolimus Nanoencapsulated Aqueous Solution Spray Vs. 0.1% Free Tacrolimus Commercial Ointment in the Treatment of Oral Lichen Planus
The goal of this clinical trial is to assess the efficacy of different formulations of the drug tacrolimus in treating patients with oral lichen planus.
- Trial name
- NCT06591884
- Testing
- Tacrolimus modified-release, tacrolimus ointment 0.1%
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Lichen Planus (LP)
Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin
This is a single center, prospective, open label, single arm, investigator initiated pilot study investigating the effect of alitretinoin on severe lichen planus with mucosal manifestations.
- Trial name
- NCT01538732
- Testing
- alitretinoin
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich