Clinical trials: Oral Melatonin
Chronic Periodontitis
Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis
This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.
- Trial name
- NCT05759416
- Testing
- Melatonin2%gel
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Edentulous; Alveolar Process, Atrophy
Melatonin and Hyaluronic Acid in Maxillary Sinus Augmentation
melatonin proved an ability to repair bone defects and enhance osseointegration of dental implants. Also, hyaluronic acid has osteopromoting properties.
- Trial name
- NCT04625179
- Testing
- Melatonin and hyaluronic acid and sinus membrane elevation, sinus membrane elevation without any materials
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Hams Hamed Abdelrahman
Diabetes Mellitus, Periodontitis
Melatonin Supports Non Surgical Periodontal Treatment in Patients With Type 2 Diabetes and Periodontitis
Background and aim: Hyperinflammatory host response associated with diabetes mellitus significantly provokes periodontal tissue destruction.
- Conditions
- Diabetes Mellitus, Periodontitis, Melatonin, Matrix Metalloproteinases
- Trial name
- NCT05870358
- Testing
- Melatonin 3 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Yağmur Saraç Gül
Burning Mouth Syndrome, Melatonin
Salivary Melatonin Levels and Sleep Quality in Patients With Burning Mouth Syndrome
Burning mouth syndrome is an idiopathic condition characterized by symptoms burning and / or pain of the oral mucosa with an orderly clinical finding. So far not found a unique way of treatment.
- Trial name
- NCT05309681
- Testing
- Epworth's sleepiness scale; unstimulated saliva sample
- Where
- Croatia
- Volunteers
- 45 people
- Sponsor
- University of Zagreb
End Stage Renal Disease, Chronic Kidney Disease
Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders
The study will evaluate the safety and efficacy of melatonin supplementation in CKD and ESRD patients with sleep disorders to reduce sleep latency times, the number of apnea/hypopneic episodes, and prolong duration in rapid eye…
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease, Sleep Disorder
- Trial name
- NCT01922999
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Southeast Renal Research Institute
Central Serous Chorioretinopathy, Melatonin
Evaluating Efficacy and Safety of Oral Melatonin in Acute Central Serous Chorioretinopathy
The goal of this clinical trial is to learn if oral melatonin can enhance visual acuity and central macular thickness in central serous chorioretinopathy (CSCR) in adults. The main questions it aims to answer are: 1.
- Conditions
- Central Serous Chorioretinopathy, Melatonin, Ocular Diseases, Visual Acuity
- Trial name
- NCT06809751
- Testing
- melatonin 3mg
- Volunteers
- 48 people
- Sponsor
- Mohsen Pourazizi
Malondialdehyde, Melatonin
Oral Melatonin as Neuroprotectant in Preterm Infants
Preterm newborns survival rates are improved, but long-term disabilities are still common. Major destructive focal lesions became less common, the most predominant lesion at present is diffuse white matter (WM damage).
- Trial name
- NCT04235673
- Testing
- melatonin
- Where
- 4 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Francesca Garofoli
Tracheal Intubation Morbidity, Laryngoscopy
Oral Melatonin VS Nebulized Dexmedetomidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation in Hypertensive Patients
The aim of this study is to compare the efficacy of oral melatonin versus nebulized dexmedetomidine in attenuating the hemodynamic response to direct laryngoscopy and endotracheal intubation in controlled hypertensive patients…
- Conditions
- Tracheal Intubation Morbidity, Laryngoscopy, Hemodynamic Response
- Trial name
- NCT06935292
- Testing
- Dexmedetomidine, Melatonin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Dexmedetomidine, Melatonin
Dexmedetomidine Infusion Versus Oral Melatonin for Prevention of Intensive Care Delirium
This study aims to compare the effect of dexmedetomidine infusion and oral melatonin on preventing delirium in intensive care unit (ICU) patients.
- Conditions
- Dexmedetomidine, Melatonin, Delirium
- Trial name
- NCT06076668
- Testing
- Dexmedetomidine, Melatonin 3 MG, Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Periodontal Diseases
Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis
Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, driven by an imbalance between bacterial pathogens and the host immune response.
- Trial name
- NCT07813936
- Testing
- 2% Melatonin gel
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Alexandria University
Bioavailability
Oral Bioavailability of Two Melatonin Supplements
Results from several clinical studies show that orally administered melatonin has low bioavailability and a very short half-life.
- Trial name
- MELFENIL (NCT05835258)
- Testing
- Melatonin with phenyl capsaicin, Melatonin without phenyl capsaicin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Sleep Disorders, Circadian Rhythm
The Efficacy of Melatonin in the Burning Mouth Syndrome
Burning mouth ( BMS) syndrome is the oral disorder characterized by an intraoral burning sensation for which no medical or dental cause can be found.
- Trial name
- BMS (NCT03788733)
- Testing
- Melatonin 3 mg
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Melasma (Facial Melasma)
Oral Melatonin Versus Oral Tranexamic Acid in the Management of Melasma
This study will compare the efficacy of oral melatonin and oral tranexamic acid in treating melasma, with the aim of determining whether melatonin is more effective than tranexamic acid, as measured by MASI scores.
- Trial name
- Melasma (NCT07169383)
- Testing
- Melatonin tablet, Tranexamic Acid (TXA)
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Hina Malik
Pain Relief After Arthroscopic Anterior Cruciate Ligament Reconstruction
Oral Melatonin With Intra Articular Analgesia on Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction
Anterior Cruciate Ligament Reconstruction (ACLR) is a common orthopedic procedure that is accompanied by moderate to severe postoperative pain and is primarily performed on an outpatient basis.
- Trial name
- ACLR (NCT07096635)
- Testing
- Melatonin, Starch tablets
- Volunteers
- 50 people
- Sponsor
- Assiut University
Epilepsy
Melatonin vs Sleep Deprivation for Nap EEG
In the pediatric population, electroencephalographic (EEG) recordings are frequently performed in sleep, as it reduces the amount of artifacts and might activate epileptiform discharges.
- Trial name
- NCT05654415
- Testing
- Melatonin, Deprivation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Post Tonsillectomy Emergence Agitation
Melatonin for Post Tonsillectomy Emergence Agitation in Pediatric
The goal of this clinical trial is to learn if melatonin can decrease emergence agitation in pediatric post tonsillectomy. The main questions it aims to answer are: Does melatonin decrease emergence agitation in pediatric post…
- Trial name
- NCT07375342
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Benha University
Oral Lichen Planus
Melatonin Epigenetic Potential in Preventing Malignant Transformation of Oral Lichen Planus
Background: Oral Lichen planus (OLP) is one of the most common oral diseases that has an unneglectable rate of malignant transformation. Recently malignant transformation has been definitively linked to epigenetic changes.
- Trial name
- NCT06533033
- Testing
- Rapid Release Capsules Melatoni, Triamcinolone Acetonide ointment, Kenacort-A orabase
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Hams Hamed Abdelrahman
Necrotizing Enterocolitis
Efficacy Of Oral Melatonin To Prevent Necrotizing Enterocolitis
Prematurity is still one of the primary causes of death in children under 5. 1-2. According to the WHO, 60% of all preterm births occur in Asia, with the Philippines accounting for around 348,900 every year. 3.
- Trial name
- NCT05033639
- Testing
- Melatonin 6 MG, Breast Milk
- Where
- Philippines
- Volunteers
- 100 people
- Sponsor
- Ilocos Training and Regional Medical Center
Alveolar Bone Loss
Effect of Topical Melatonin Application on Dental Implant Osseointegration and Marginal Bone Level
Background: Melatonin (N-acetyl-5-methoxy-tryptamine) is an indoleamine synthesized and secreted by the pineal gland and other organs, such as the retina, bone marrow, and intestines in a circadian pattern.
- Trial name
- NCT04229719
- Testing
- N-acetyl-5-methoxytryptamine
- Where
- Iraq
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Melasma, Treatment Outcome
Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma
This study compares the effectiveness of two oral medications-melatonin and tranexamic acid -in treating melasma, a common skin condition that causes dark facial patches.
- Conditions
- Melasma, Treatment Outcome, Recurrence
- Trial name
- TXA-MELA (NCT07034560)
- Testing
- Tranexamic Acid (TXA), melatonin (Circadin)
- Where
- Thailand
- Volunteers
- 75 people
- Sponsor
- Thammasat University