Clinical trials: Oral Microbiota
Lung Cancer
Oral Microbiome Diagnostics of Lung Cancer
The study aims to develop a deep learning-based diagnostic method for lung cancer using the oral microbiome. This innovative approach involves establishing an observational cohort of 576 individuals, including lung cancer…
- Trial name
- NCT06270992
- Testing
- NCCN (National Comprehensive Cancer Network) diagnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Digestive Cancer
Association Between Composition of the Gut Microbiota and Nutritional Status in Digestive Oncology
Nutritional status represents a crucial issue in the management of cancer patients, as between 40% and 60% of them suffer from malnutrition at the time of diagnosis.
- Trial name
- ONCONUTRIBIOTA (NCT07260617)
- Testing
- Not applicable- observational study
- Where
- 3 sites in France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease, Oral Infection
Oral Therapeutic Education in Stimulated Parkinsonian Patients
The effect of periodontal disease on the general condition of patients remains today underestimated in Parkinson's disease. The BUCCO-PARK project aims to carry out an exploratory study of oral therapeutic education on the…
- Trial name
- BUCCO-PARK (NCT03965390)
- Testing
- Oral education
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Rennes University Hospital
Chronic Periodontitis, Occlusal Trauma
Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma
Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.
- Trial name
- NCT03621891
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Periodontitis, Alzheimer Disease
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority.
- Trial name
- ORAMICAL (NCT05077618)
- Testing
- sampling of dental plaque and blood sample during the treatment
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Head and Neck Cancer
Impact of the Oral Microbiota on Relapse in HNSCC Patients
to characterise the impact of microbiota in radiotherapy efficacy
- Trial name
- MICR-ORL (NCT06807034)
- Testing
- buccal swabs
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut Sainte Catherine
Oral Bacterial Infection, Oral Infection
Effects of Mouthrinse on the Microbiome of the Oral Cavity and GI Tract
The purpose of this research study is to identify the effects of 2 over-the-counter mouthwashes on bacteria and 3 viruses in the participant's mouth and gut.
- Conditions
- Oral Bacterial Infection, Oral Infection, Microbial Colonization, Viral Infection
- Trial name
- Microbiome (NCT05603650)
- Testing
- Lumineux Oral Essentials rinse, Listerine rinse
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Oral Mucositis, Microbiota
Microbiota and Symptom Distress in Head and Neck Cancer Patients Receiving Radiotherapy
The investigators plan to conduct a 3-year pioneering care research project for mucositis in cancer patients. These include: (1) an analysis of the incidence and severity of mucositis, severity, treatment methods, and treatment…
- Conditions
- Oral Mucositis, Microbiota, Symptoms and Signs
- Trial name
- NCT04843644
- Testing
- honey, propolis, Control
- Volunteers
- 250 people
- Sponsor
- Taipei Medical University
Oral Health, Parkinson Disease
Preliminary Study of the Quality of the Oral Flora in Parkinson's Patients
This is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with Parkinson disease
- Trial name
- PARKIDENT (NCT03827551)
- Testing
- Delivery of oral hygiene advices
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Clostridioides Difficile Infection, Drug Resistance, Bacterial
Effect of Oral Microbiota on MDRO Decolonization
Randomized, placebo-controlled trial to evaluate the safety and efficacy of oral intestinal microbiota capsules for decolonizing multidrug-resistant organisms (MDROs) and Clostridioides difficile in patients requiring prolonged…
- Conditions
- Clostridioides Difficile Infection, Drug Resistance, Bacterial, Gastrointestinal Microbiome, Multidrug-resistant Colonization
- Trial name
- NCT07496502
- Testing
- Microbiota capsule
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Gingival and Periodontal Disease, Caries, Dental
Clinical Evaluation of the Antibacterial Activity of Thioglycosides Extracted from White Mustard - Bamberka in Oral Hygiene. Evaluation of Periodontal Parameters and Oral Microbiota in Patients.
Brief Summary The goal of this randomized clinical trial is to evaluate the clinical and antibacterial effects of a herbal toothpaste containing white mustard (Sinapis alba) extract in patients diagnosed with gingivitis.
- Trial name
- NCT06908265
- Testing
- Toothpaste including mustard extract
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Microbial Colonization
The Effect of the Fermented Tea Beverage Kombucha on the Oral and Gut Microflora
The purpose of the project is to investigate if consumption of the fermented tea beverage kombucha has an effect on the gut and/or oral microbiota, and further if it depends on the content of living bacteria or is inherent even…
- Trial name
- NCT03873350
- Testing
- Consumption of kombucha, Consumption of heat-sterilized kombucha
- Where
- Sweden
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Lund University
Peanut Allergy
Evaluating the Safety and Efficacy of Oral Encapsulated Fecal Microbiota Transplant in Peanut Allergic Patients
This is a Phase I trial to evaluate the safety and efficacy of oral encapsulated fecal microbiota transplantation (FMT) in the treatment of peanut allergy.
- Trial name
- NCT02960074
- Testing
- Fecal Microbiota Capsule
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rima Rachid
Dental Plaque
Probiotic Lactobacillus Reuteri and Oral Microbiota
In February 2013, 44 healthy adults was recruited and randomized to daily intake of lozenges with or without Lactobacillus reuteri strains DSM 17938 and PTA 5289 for 12 weeks.
- Trial name
- OMICI (NCT02311218)
- Testing
- Lactobacillus reuteri DSM 17938 and PTA 5289
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Umeå University
Health Behavior
Sweet Cheeks: How Early Nutrition Affects Oral Microbiota Populations and Disease Incidence
Dietary and oral hygiene habits are known to affect oral microorganisms and disease incidence, but most research has focused on preschool aged (2-4 yr old) children.
- Trial name
- NCT01836952
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Obesity
Effect of Oral Calcium Butyrate Supplementation in Obesity
Obesity is characterized by gut microbiota dysbiosis, in which beneficial metabolites such as butyrate are reduced. Butyrate is a short-chain fatty acid produced by microbial fermentation that plays a key role in maintaining…
- Trial name
- Pacayeliztli (NCT07583017)
- Testing
- Calcium butyrate
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Locally Advanced Oral Squamous Cell Carcinoma
Prospective Cohort Study on Oral Microbiome Changes in Patients With Locally Advanced Oral Squamous Cell Carcinoma Following Neoadjuvant Chemoimmunotherapy
Investigating the Relationship Between Oral Microbiome Alterations and Tumor Markers in Locally Advanced Oral Squamous Cell Carcinoma (LA-OSCC) After Neoadjuvant Chemoimmunotherapy: Implications for Therapeutic Efficacy…
- Trial name
- NCT07111455
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Zhujiang Hospital
Healthy Subjects With Fixed Orthodontics
The Effect of Probiotic Lactobacillus Reuteri Prodentis Consumption on Gingival Crevicular Fluid Inflammatory Response and Metagenomic Profiles of Oral Microbiome in Orthodontic Patients.
In this study, researchers will test the effectiveness of probiotic consumption against oral pathogenic bacteria and reduce the occurrence of gingival inflammation in subjects using orthodontic fixed appliances (braces).
- Trial name
- NCT04847960
- Testing
- BioGaia Probiotic Lozenges
- Where
- Indonesia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Trisakti University
Dental Caries
Does Administration of Probiotics During Infancy Increase the Caries Risk of a Child
Aim: to examine caries occurrence in children who ten years ago received a mixture of probiotics during infancy. Hypothesis: the administration of probiotics during infancy has no effect on future dental health.
- Trial name
- NCT01424852
- Testing
- Probiotics in infant milk formula
- Where
- Finland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Turku
Diabetes Mellitus Type 2, Fecal Microbiota Transplantation (FMT)
Fecal Microbiota Transplantation Intervention on Microbiota Composition and Insulin Sensitivity in Diabetes
The purpose of the trial is to investigate the effect of fecal microbiota transplantation versus placebo on glycemic metabolism and gut microbiota composition in people with type 2 diabetes.
- Conditions
- Diabetes Mellitus Type 2, Fecal Microbiota Transplantation (FMT), Oral Glucose Tolerance Test, Continuous Glucose Monitoring
- Trial name
- FeMIC (NCT07375797)
- Testing
- Fecal Microbial Transplantation
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Central Jutland Regional Hospital