Clinical trials: Oral Microbiota
Periodontal Disease, Atherosclerosis
Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults
We propose to examine a population of Native Americans who have had little or no dental care, and to determine if periodontal disease is associated with early signs of vascular dysfunction or systemic inflammation.
- Trial name
- NCT01376791
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Gingivitis, Orthodontic Appliance Complication
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions.
- Trial name
- NCT04598633
- Testing
- Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Chronic Periodontitis
CBD Effects on Periodontal Health of Patients With Chronic Periodontitis
The suppression of chronic periodontitis after application of dental gel and toothpaste containing cannabidiol (CBD) will be evaluated.
- Trial name
- Stoma-CBD (NCT05498012)
- Testing
- Cannabidiol dental gel, Cannabidiol toothpaste
- Where
- Czechia
- Volunteers
- 90 people
- Sponsor
- Palacky University
Dental Caries
Delivery of Polyphenols in Gum as an Anti-Caries Agent
The short-term effects of chewing gum containing xylitol and/or blackberry extract on oral microbiota was studied. Fifty healthy adults participated in a randomized, placebo-controlled, cross-over design study.
- Trial name
- BBE (NCT05133557)
- Testing
- Chewing gum containing xylitol and blackberry extract (BBE)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Craig Miller
Carbapenem-Resistant Enterobacteriaceae Infection
Oral Capsule Faecal Microbiota Transplantation for CPE Decolonization
Double-blinded, randomised controlled trial to evaluate the clinical efficacy of a single dose of oral capsule-administered faecal microbiota transplantation (FMT) for carbapenemase-producing Enterobacteriaceae (CPE) intestinal…
- Trial name
- NCT04746222
- Testing
- Oral capsule faecal microbiota transplantation
- Volunteers
- 108 people
- Sponsor
- Tan Tock Seng Hospital
C. Difficile
Fecal Microbiota Transplantation to Treat Recurrent C. Difficile Associated Diarrhea Via Retention Enema or Oral Route
The objective of the study is to investigate the safety of a frozen or lyophilized inoculum administered, respectively, by retention enema or capsules in patients with recurrent C. difficile associated diarrhea (RCDAD).
- Trial name
- NCT02449174
- Testing
- Frozen Microbiota, Lyophilized Microbiota
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetes Mellitus Type 2, Fecal Microbiota Transplantation (FMT)
Fecal Microbiota Transplantation Intervention on Microbiota Composition and Insulin Sensitivity in Diabetes
The purpose of the trial is to investigate the effect of fecal microbiota transplantation versus placebo on glycemic metabolism and gut microbiota composition in people with type 2 diabetes.
- Conditions
- Diabetes Mellitus Type 2, Fecal Microbiota Transplantation (FMT), Oral Glucose Tolerance Test, Continuous Glucose Monitoring
- Trial name
- FeMIC (NCT07375797)
- Testing
- Fecal Microbial Transplantation
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Central Jutland Regional Hospital
Periodontitis
PAROMIP Pilot Study PAROdontites & MIcrobiota Periodontal
A new classification of periodontal diseases was created in 2018. the investigators want to know if this clinical classification is based, or not, on a biological reality.
- Trial name
- PAROMIP (NCT04251650)
- Testing
- subgingival plaque sample, CGF sample
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Nasal Septal Perforation
Oral Mucosal Grafting for Nasal Septal Perforation Repair
This study will assess how often a hole in the nasal septum (the wall separating the two sides of the nose), closes completely after surgical repair using tissue taken from the lining of the patient's own mouth.
- Trial name
- NCT07902856
- Testing
- Nasal Septal Perforation Repair With an Autologous Oral Mucosal Graft
- Where
- 3 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Dental Caries
Impact of Atraumatic Restorative Treatment and Oral Health Promotion on Psychological and Salivary Aspects of Children
This study evaluated the impact of atraumatic restorative treatment associated with oral health educational strategy on dental anxiety, oral health-related quality of life and salivary biochemical and microbiological…
- Trial name
- NCT03100773
- Testing
- Oral health educational strategy, Atraumatic Restorative Treatment
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Orthodontic Treatment on Oral Microbiota and Salivary Proteins
Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited.
- Conditions
- Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Caries, Dental
- Trial name
- NCT06824493
- Testing
- no interventions, No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Eczema, Allergy
Probiotics in Prevention of Allergies, Obesity and Caries
During the period of 2000-2003, 179 healthy, term infants with no previous signs of allergic disease were recruited and randomized to daily intake of cereals with or without the addition of Lactobacillus paracasei subspecies…
- Conditions
- Eczema, Allergy, Asthma, Obesity
- Trial name
- ELEFANT (NCT00894816)
- Testing
- Lactobacillus F19
- Where
- Sweden
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Umeå University
Periodontal Diseases, Periodontitis
Intake of Nitrate-rich Vegetables and Their Effect on Inflammatory Molecules and Oral Microbiota of Patients With Periodontitis
Vegetables, mainly green leafy ones and some others like beets, are a rich source of nitrate. Nitrate metabolism has shown benefits to the body and there are recent studies that agree that the consumption of nitrates from…
- Trial name
- NCT05232331
- Testing
- Intake of nitrate rich vegetables
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- University of Guadalajara
Periodontal Health, Gingivitis
Effect of Probiotics on the Periodontal Status of Orthodontic Patients
Gingival inflammation (gingivitis) is commonly reported in teenagers with fixed orthodontic devices (FOD). Indeed, FODs promote the accumulation of plaque and interfere with the efficacy of tooth brushing.
- Trial name
- POP (NCT04634201)
- Testing
- Oral probiotics (L. reuteri)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Lille
Antibiotic
The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health
The aim of the present project (non-inferiority trial) is to evaluate the effect of different antibiotic strategies (long-span vs.
- Trial name
- NCT06378502
- Testing
- Amoxicillin Short, Amoxicillin Long
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universita degli Studi di Genova
Microbiota
the Microbiota Are Associated With Iodine-131 Therapy and Hypothyroidism
Thyroid cancer is a common neck malignancy. Currently, total thyroidectomy or subtotal thyroidectomy is the main method for the treatment of thyroid cancer patients.
- Trial name
- NCT03574051
- Testing
- Probiotic
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Low-grade Oral Dysplasia
Lactobacillus Lozenges as Preventative Care in Low-grade Dysplasia
There are limited evidence-based management options for patients with low-grade oral dysplasia. Despite the risk of malignant transformation, management is frequently limited to risk factor reduction (such as smoking cessation)…
- Trial name
- NCT05707702
- Testing
- Probiotic oral lozenges, Standard of care for oral dysplasia
- Where
- United States
- Sponsor
- Boston Medical Center
COVID-19, Microbial Colonization
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease
Determining whether in the mouth there are differences between the participant groups in the nature and activity of mucosal innate immunity, in immune responses to SARS-COV2 antigens, or in the oral microbiome
- Conditions
- COVID-19, Microbial Colonization, Oral Disease, Periodontal Diseases
- Trial name
- MIMSA (NCT05212766)
- Testing
- COVID infection, COVID vaccination, Oral examination
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- King's College London
Lung Cancer
Oral Microbiome Diagnostics of Lung Cancer
The study aims to develop a deep learning-based diagnostic method for lung cancer using the oral microbiome. This innovative approach involves establishing an observational cohort of 576 individuals, including lung cancer…
- Trial name
- NCT06270992
- Testing
- NCCN (National Comprehensive Cancer Network) diagnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Peri-implantitis
Effect of Metallic Particles on the Progression of Peri-Implantitis
This observational cross-sectional study aims to investigate the presence and characteristics of metallic micro- and nanoparticles in peri-implant tissues and their potential association with peri-implantitis progression, the…
- Trial name
- NCT07792499
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Barcelona