Clinical trials: Oral Microbiota
Alzheimer Disease
Oral Fecal Microbiota Transplant Feasibility Study in Alzheimer's Disease
The goal of this study is to assess the safety and feasibility of an oral fecal microbiota transplant (FMT) intervention for Alzheimer's disease (AD).
- Trial name
- AMBITION (NCT03998423)
- Testing
- Fecal Microbiota Transplant
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Black Stains
Black Stains' Epidemiology, Clinical Evaluation and Dietary Habits: a Clinical Trial.
The aim of this study is to investigate epidemiology and treatment possibilities of black stains, with the assessment of a possible correlation with patients' dietary habits. Patients will be randomly divided into three groups.
- Trial name
- NCT04865796
- Testing
- Lactoferrin products, Probiotics products, Standard home oral care
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Pavia
HIV-1-infection
Safety of FMT Using Oral Encapsulated PRIM-DJ2727 in HIV
The purpose of this study is to determine whether oral fecal microbiota transplantation (FMT) is safe for people with human immunodeficiency virus (HIV) infection.
- Trial name
- NCT03329560
- Testing
- Oral fecal microbiota transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center, Houston
Dysmenorrhea
The Impact of Oral Probiotics on Improving the Quality of Life in Patients With Dysmenorrhea.
Menstrual pain is mainly divided into primary dysmenorrhea and secondary dysmenorrhea, the former is caused by menstrual uterine muscle movement; the latter is caused by certain diseases, such as Endometriosis, Uterine fibroids…
- Trial name
- NCT07530081
- Testing
- High dose Probiotic, Low dose probiotic
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Glac Biotech Co., Ltd
Saliva Altered, Taste, Altered
Taste Perception, Salivary Proteins & the Oral Microbiome
Genetic differences in taste are believed to play an important role in food selection, especially for strong-tasting foods and beverages.
- Trial name
- NCT04107688
- Testing
- Control, CPE
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Oral Microbiota, Pancreatitis
The Characteristics of Oral Microbiota in Chronic Pancreatitis and Autoimmune Pancreatitis
There are more than 700 different bacteria colonized in human oral cavity, which are collectively referred to as oral microbiota.
- Conditions
- Oral Microbiota, Pancreatitis, Pancreatic Cancer
- Trial name
- NCT07015580
- Testing
- 16S rRNA sequencing
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Oral Microbiota, Periodontal Diseases
Food Biodiversity and Human Health
In Western countries, one of the major nutritional challenges requires reducing the proportion of animal proteins and increasing the proportion of vegetable proteins in the daily plate.
- Trial name
- BIOQUALIM (NCT06315088)
- Testing
- Einkorn Diet, Intermediate oral microbiota, Periodontal health status
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Hospices Civils de Lyon
Oral Mucositis, Microbiota
Microbiota and Symptom Distress in Head and Neck Cancer Patients Receiving Radiotherapy
The investigators plan to conduct a 3-year pioneering care research project for mucositis in cancer patients. These include: (1) an analysis of the incidence and severity of mucositis, severity, treatment methods, and treatment…
- Conditions
- Oral Mucositis, Microbiota, Symptoms and Signs
- Trial name
- NCT04843644
- Testing
- honey, propolis, Control
- Volunteers
- 250 people
- Sponsor
- Taipei Medical University
Dietary Exposure
Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Production Capacity
In this project, the investigators aim to explore the impact of dietary L-carnitine supplementation on the TMAO production capacity of gut microbiota.
- Trial name
- NCT02838732
- Testing
- L-carnitine supplementation (500 mg per tablet per day, purchased from GNC company)
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tryptophan Metabolism Alterations, Celiac Disease
Tryptophan for Impaired AhR Signaling in Celiac Disease
This is a prospective, randomized, double-blind, placebo-controlled exploratory trial to evaluate the effect of L-tryptophan supplementation on celiac-related symptoms in individuals who have biopsy-confirmed celiac disease (CeD)…
- Trial name
- TIARSCeD (NCT05576038)
- Testing
- L-Tryptophan, Freedom SimpleCap Powder
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Early Childhood Caries
A Clinical Trial of Silver Diamine Fluoride to Arrest Early Childhood Caries in Young Children
Silver diamine fluoride (SDF) is an antibiotic liquid that has the potential to arrest Early Childhood Caries in young children and delay treatment until children can be seen in outpatient settings.
- Trial name
- NCT04054635
- Testing
- Silver diamine fluoride
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- University of Manitoba
Pregnancy, Periodontal Disease
Lactoferrin-Based Oral Care for Periodontal Health in Pregnancy
This randomized controlled clinical trial aims to evaluate the effectiveness of a lactoferrin-based oral hygiene protocol in improving periodontal health during pregnancy.
- Conditions
- Pregnancy, Periodontal Disease, Gingivitis, Oral Microbiota
- Trial name
- LBC-PREG (NCT07069140)
- Testing
- Lactoferrin-based Toothpaste and Mouthwash (Emoform Glic), Lactoferrin-Based Toothpaste Only (Emoform Glic)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Inflammatory Bowel Disease (IBD)
Omics-driven Research on the Gut-Oral Microbiome, Metabolome, Lifestyle, and Clinical Integration in Korean Inflammatory Bowel Disease
The inflammatory bowel disease (IBD) is a condition that afflects approximately 5 million people worldwide, with 1.4 million in the US and 2.2 million in Europe.
- Trial name
- ORIGIN (NCT06124833)
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Chang Kyun Lee
Oral Microbiome
Biogeography of the Oral Microbiome
A cross-sectional study to metatranscriptomically analyze and compare the oral microbiome in different environmental niches within the oral cavity.
- Trial name
- NCT05672953
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Viome
Peri-Implantitis, Peri-Implant Health
Comparison of the Effectiveness of Two Different Surgical Therapeutic Protocols of Peri-implantitis
The purpose of the present study is to compare the 1-year clinical, radiographic and microbiological outcomes and patients' satisfaction following surgical treatment of peri-implantitis after applying two different surface…
- Trial name
- NCT05899933
- Testing
- Non-surgical peri-implant therapy, Implantoplasty, Erythritol Air-abrasive device
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Microbiota-related Disease, Oral Hygiene
Interdental Hygiene Methods in Young Adults
Oral health is essential for overall well-being and systemic health. A key factor in preserving this health is maintaining the balance of the interdental microbiota, which involves regulating the quantity of pathogenic bacteria…
- Conditions
- Microbiota-related Disease, Oral Hygiene, Periodontal Diseases
- Trial name
- HIJA (NCT06848790)
- Testing
- Calibrated interdental brush
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Chronic Obstructive Pulmonary Disease
The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease
Determine the effect of twice-daily chlorhexidine oral rinse on oral and lung microbiota biomass in subjects with chronic obstructive pulmonary disease (COPD) with chronic bronchitis.
- Trial name
- CLIMB (NCT02252588)
- Testing
- Chlorhexidine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Fixed Orthodontic Retainer, Orthodontic Appliances, Removable
Bacterial Diversity Study Using 16S rRNA Sequencing of Periodontal Samples From Patients With Orthodontic Retainers
After completion of orthodontic treatment, a retention phase is required to prevent relapse of tooth malposition. Fixed retention in the mandibular anterior region is commonly used.
- Conditions
- Fixed Orthodontic Retainer, Orthodontic Appliances, Removable, Orthodontic Appliance Complication, Gingivitis
- Trial name
- Ortho-Perio (NCT07718061)
- Testing
- Fixed Orthodontic Retainer, Removable Essix-Type Orthodontic Retainer
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad de Murcia
Ventilator Associated Pneumonia ( VAP)
Effect of Two Oral Care Methods on Oral Flora and VAP in Mechanically Ventilated Patients
This randomized controlled trial aims to evaluate the effect of two oral care methods on oral bacterial colonization and ventilator-associated pneumonia (VAP) in mechanically ventilated intensive care unit (ICU) patients.
- Trial name
- ORAVAP-RCT (NCT07283380)
- Testing
- Pediatric toothbrush, Sponge stick
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Marmara University
Parkinson's Disease
Characterization of Fecal Microbiome Changes After Administration of PRIM-DJ2727 in Parkinson's Disease Patients
The purpose of this study is to characterize the intestinal flora in subjects with Parkinson's Disease (PD) and to determine safety and trends in improvements in diversity of colonic microbiome following fecal microbiota…
- Trial name
- NCT03026231
- Testing
- PRIM-DJ2727
- Sponsor
- The University of Texas Health Science Center, Houston