Clinical trials: Oral Microbiota
Erythema Migrans of Lyme Disease
Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))
The aim of this study is to assess the effect of Saccharomyces boulardii CNCM I-745 on gut microbiota in patients undergoing antibiotic therapy (in the context of erythema migrans (early skin form of Lyme borreliosis)).
- Trial name
- SUBLYME (NCT06451913)
- Testing
- Amoxicillin + Saccharomyces boulardii CNCM I-745, Stool samples, BSFS : Bristol Stool Form Scale
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- Biocodex
Medication Adherence
Lifestyle, Self-medication and Use of Nutraceuticals in a Population of Italian and Spanish Students
University students are considered a population class with a high risk of malnutrition and/or obesity, metabolic and cardiovascular diseases, with a tendency to misuse drugs and self-medication.
- Trial name
- STANIS (NCT04099420)
- Testing
- Lifestyle counseling
- Where
- 3 sites in Italy, Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Maura Palmery
Menopause
Menopause and Oral Microbiome
The study examines the saliva and dental plaque microbiome of women aged 35-65 in two groups: postmenopausal (case) and premenopausal (control). For this purpose, Illumina Platform to sequence 16S rRNA gene regions will be used.
- Trial name
- NCT05335733
- Testing
- Intraoral examination, saliva, dental plaque and serum collection.
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Ege University
Clostridium Difficile Infection Recurrence
Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Recurrent C. Diff
Subjects with recurrent C. difficile infection will receive an oral dose of CP101 capsules one time in Treatment Group I or matching placebo one time in Treatment Group II.
- Trial name
- PRISM3 (NCT03110133)
- Testing
- Full Spectrum Microbiota
- Where
- 58 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- Finch Research and Development LLC.
Rheumatoid Arthritis, Psoriatic Arthritis
Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and damage. RA attacks the lining of the joints (synovium), causing swelling that can result in aching and throbbing, and eventually deformity.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Periodontal Disease
- Trial name
- NCT01198509
- Testing
- doxycycline, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Mild Cognitive Impairment (MCI), Aging
Elderberry Functional Gum and Cognitive & Oral Health in Older Adults
Globally, the aging population is increasing rapidly, leading to a dramatic rise in the prevalence of Alzheimer's disease and other types of dementia.
- Conditions
- Mild Cognitive Impairment (MCI), Aging, Oral Microbiome
- Trial name
- NCT07054645
- Testing
- Elderberry Anthocyanin Chewing Gum
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Infertility, Female, Infertility
Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Female inability to conceive a child. The purpose of this prospective randomized, double-blinded, double dummy, two-arm cross-over study is to investigate the difference on histological, transcriptional and immunological level in…
- Conditions
- Infertility, Female, Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- NCT03677336
- Testing
- Dydrogesterone Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Rheumatoid Arthritis
Methotrexate in Patients with Early Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting the small joints of hands and feet, but may also present with systemic, extraarticular features.
- Trial name
- MTXRA (NCT05353829)
- Testing
- Methotrexate
- Where
- 13 sites in Sweden
- Volunteers
- 212 people
- Sponsor
- Region Västerbotten
Antibiotic Resistant Bacteria
Effect of Minocycline & Amoxicillin on Antibiotic Resistant Bacteria and Indigenous Microbiotas
A randomised, open labelled study design is selected in order to determine the emergence and persistence of antibiotic resistant bacteria in humans and on the composition of the indigenous microbiotas at various body sites.
- Trial name
- ANTIRESDEV (NCT02030912)
- Testing
- 3 doses of amoxicillin daily for 7 days, 2 doses of minocycline daily for five days
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Helperby Therapeutics Ltd
Peri-Implantitis
Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis
This randomized clinical trial evaluates the clinical and microbiological (microbial complexes and changes in the diversity of the submucosal biofilm) effects of MTZ+AMX as adjuncts to anti-infectious surgical treatment plus Er…
- Trial name
- NCT05444218
- Testing
- Open flap debridement, Er: YAG irradiation, Metronidazole
- Where
- Brazil
- Volunteers
- 89 people
- Sponsor
- University of Guarulhos
Parkinson Disease, Oral Infection
Oral Therapeutic Education in Stimulated Parkinsonian Patients
The effect of periodontal disease on the general condition of patients remains today underestimated in Parkinson's disease. The BUCCO-PARK project aims to carry out an exploratory study of oral therapeutic education on the…
- Trial name
- BUCCO-PARK (NCT03965390)
- Testing
- Oral education
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Rennes University Hospital
Morbid Obesity
Changes of Oral and Intestinal Microbiota After Bariatric Surgery
Purpose The aim of this study was to analyze the changes of microbiota among patients undergoing LSG or LRYGB on two levels of gastrointestinal tract (using oral swab and stool sample).
- Trial name
- NCT04582006
- Testing
- Bariatric surgery
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Jagiellonian University
Chalazion
Probiotics for Treatment of Chalazion in Adults
There is growing evidence encouraging probiotics use in several diseases. The aim of the investigator's study is to define the possible beneficial impact of probiotics on adults suffering from chalazia.
- Trial name
- NCT04342507
- Testing
- conservative treatment, probiotics
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Molise
Mouth Diseases
Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene
The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days.
- Trial name
- NCT02913235
- Testing
- Oral hygiene discontinuation group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Enterobacteriaceae Infections, Fecal Microbiota Transplantation
Pilot Study Using Oral Capsule FMT to Decolonize GI CRE
Carbapenem-Resistant Enterobacteriaceae (CRE) are bacteria that have become resistant to carbapenems by producing enzymes that break down carbapenems.
- Trial name
- NCT03527056
- Testing
- Fecal Microbiota Transplantation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Microbial Colonization
The Influence of Endurance Sports Activity on the Oral Microbiota of Young Adults.
The oral cavity is an easily accessible anatomical site that accurately reflects the health of the individual. The mouth is considered an early indicator of biological aging, leading to the identification of oral biomarkers…
- Trial name
- ORAMICAP (NCT05765422)
- Testing
- salivar and gum sampling
- Where
- France
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Allergy, Peanut, Peanut Allergy
Evaluating the Safety and Efficacy of Oral Encapsulated Microbiota Transplantation Therapy in Peanut Allergic Patients
This is a phase II trial that aims at evaluating the safety and tolerability of oral encapsulated fecal microbial transplantation therapy (MTT) in peanut allergic patients.
- Conditions
- Allergy, Peanut, Peanut Allergy, Peanut Hypersensitivity, Peanut-Induced Anaphylaxis
- Trial name
- NCT05695261
- Testing
- Microbial Transplantation Therapy, Antibiotic, Oral Immunotherapy (OIT)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Rima Rachid
Pancreatic Cancer
Correlation Between Complications After Pancreaticoduodenectomy and Microbiota
Pancreaticoduodenectomy is the most performed pancreatic surgery for malignant or premalignant tumors of the region of the head of the pancreas. Its post-operative morbidity is very high, over 40%.
- Trial name
- COMPAMIC (NCT04931069)
- Testing
- Microbiota analysis
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Toulouse
Streptococcus Mutans
Investigation of Oral Microflora of Infants
The placement of cariogenic microorganisms in oral microflora is an important factor in dental caries. The aim of this study is to research from whom, when and how the cariogenic microorganisms are first transmitted to the…
- Trial name
- NCT04228861
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Inonu University
Dental Caries
Effects of Nystatin Suspension Oral Application on Oral Microbial Community
The purpose of this study is to examine the effect of a prescription mouth rinse (Nystatin),an FDA approved drug, on the different types of bacteria in the mouth.
- Trial name
- NCT04550546
- Testing
- Nystatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester