Clinical trials: Oral Microbiota
Oral Health, Parkinson Disease
Preliminary Study of the Quality of the Oral Flora in Parkinson's Patients
This is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with Parkinson disease
- Trial name
- PARKIDENT (NCT03827551)
- Testing
- Delivery of oral hygiene advices
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Pre-diabetes
Therapeutic Intervention of Eriomin Associated with Metformin in the Control of Hyperglycemia in Pre-Diabetic Patients
Citrus bioflavonoids, such as eriocitrin, hesperidin and naringin, have been shown improved hyperglycemia, insulin resistance and systemic inflammation, related to the development of type 2 diabetes.
- Trial name
- Eriomin+Met (NCT06005142)
- Testing
- Eriomin, Washout
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Thais Cesar
Diabetes Mellitus,Type 2, Periodontitis
Effects of a Probiotic on Oral Microbiota and Glycemic Control in Type 2 Diabetics; A Randomized Clinical Trial
The present study evaluated clinically the effects of a probiotic on oral microbiota and glycemic control in T2 diabetic patients with periodontal disease.
- Trial name
- NCT04913909
- Volunteers
- 70 people
- Sponsor
- Istanbul University
Periodontitis
Alb-PRF as an Adjunct to Nonsurgical Periodontal Therapy
Periodontitis is an inflammatory disease that damages the tissues supporting the teeth. Nonsurgical periodontal therapy is the standard initial treatment, but deep periodontal pockets may remain after treatment.
- Trial name
- NCT07794046
- Testing
- Nonsurgical Periodontal Therapy, Albumin Platelet-Rich Fibrin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Halil Ata BIÇAKÇIOĞLU
Older Adults
VR Gaming and Its Impact on Functional Status and Quality of Life in Seniors
This project examined the impact of virtual reality (VR)-based physical activity on the functional status and quality of life (QoL) of older residents in a nursing home.
- Trial name
- NCT06864325
- Testing
- VR-training
- Where
- 2 sites in Poland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Sjögren's Syndrome
DNA Exome Sequencing TCM for Sjögren's Syndrome
To explore the association among gene, TCM pattern, TCM tongue diagnosis and TCM pulse diagnosis with the DNA Exome sequencing tools for Sjögren's syndrome
- Trial name
- NCT03935373
- Testing
- DNA Exome sequencing, Oral microbiome, Proteomics
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hyaluronic Acid, Periodontal Therapy
Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers
The goal of this clinical trial is to evaluate whether hyaluronic acid (HA) improves periodontal healing in people with periodontal disease who smoke.
- Conditions
- Hyaluronic Acid, Periodontal Therapy, Oral Microbiota, Oxidative Stress
- Trial name
- NCT07597213
- Testing
- Scaling and Root Planing, Hyaluronic Acid (HYADENT BG)
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Marmara University
Dental Caries
Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient
This clinical trial aims to learn more about the working mechanism of an antimicrobial agent used to manage dental caries, especially in young, uncooperative children.
- Trial name
- NCT06699199
- Testing
- Silver diamine Fluoride 38%, Silver diamine fluoride- potassium iodide
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- King Abdulaziz University
Gingival Inflammation
Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.
This is a clinical research study designed to measure changes in inflammation and the oral microbiome during a phase of good oral hygiene and the absence of oral hygiene.
- Trial name
- ILIMSIR (NCT06966492)
- Testing
- Stannous Fluoride Toothpaste (SnF)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Stroke
Oral and Salivary Biomarkers Associated With Stroke
This observational study aims to investigate associations between oral and salivary biomarkers and stroke. Adults with stroke and healthy controls will undergo clinical oral assessment and unstimulated saliva collection.
- Trial name
- NCT07357155
- Where
- 2 sites in Algeria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Center (CHU) of Constantine, Algeria
Covid19, Periodontitis
Oral Health, Microbial Burden and COVID-19
An observational study of patients with COVID-19 confirmed cases (with various degrees of severity) and controls. Oral and nasal swabs will be taken from 150 patients (50 with mild form and 50 with severe form of COVID-19 with or…
- Trial name
- ORACLE (NCT04668911)
- Testing
- Swab
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eastman Dental Insitute and Hospital
Early Childhood Caries
Investigation of Supragingival Plaque Microbiome in Early Childhood Caries
The purpose of this study was to characterize the supragingival plaque microbiome in children with early childhood caries and identify potential microorganisms associated with caries.
- Trial name
- NCT04456335
- Testing
- Collection of supragingival plaque from caries free children
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Trakya University
Changes in the Oral Microbiota
Oral Administration of Colostrum to Premature Babies: Impact on the Oral Microbiota
Oropharyngeal administration of mother's colostrum to premature infants has been proposed as a stimulus to the oropharyngeal lymphatic tissues to decrease the incidence of pneumonia and sepsis, particularly in intubated babies.
- Trial name
- NCT02306980
- Testing
- Colostrum
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Davis
Obesity, Morbid
BASUN - Risks for Malnutrition, Metabolic Bone Disease and Impaired Oral Health After Obesity Treatment
Weight-reducing obesity surgery (OS) generally gives good results but complications are common; e.g. impaired weight loss, weight regain, bowel pain, diarrhea, vitamin/mineral deficiency, osteoporosis and impaired dental health.
- Trial name
- BASUN (NCT03152617)
- Where
- Sweden
- Volunteers
- 1,400 people
- Sponsor
- Göteborg University
Colorectal Cancer Stage II, Colorectal Cancer Stage III
Study of Oral Metronidazole on Postoperative Chemotherapy in Colorectal Cancer
Fusobacterium nucleatum (Fusobacterium nucleatum, Fn) has been identified as an independent risk factor for recurrence of colorectal cancer.
- Trial name
- NCT04264676
- Testing
- Metronidazole Oral Tablet
- Where
- 4 sites in China
- Volunteers
- 294 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Orthodontic Appliance Complication
Assessment of Bacterial Loads of Essix Retainers in Patients Under Retention Therapy
The aim of this study is to investigate the bacterial loads present on essix retainers in patients' contention therapy. Patients are randomly divided into three groups, depending on the product used for the cleansing of the…
- Trial name
- NCT04871763
- Testing
- Retainers' Cleansing with Geldis®, Retainers' Cleansing with tablets, Retainers' cleansing with water
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Head and Neck Cancer
Microbiota-guided Radiotherapy for Head and Neck Cancer
Head and neck cancer (HNC) is the sixth most common cancer worldwide. Therapeutic outcomes for HNC remain unsatisfactory and heterogeneous, with 5-year survival rates ranging from 28% to 67% overall.
- Trial name
- MIGRAHN (NCT07253402)
- Testing
- External beam radiotherapy for head and neck cancer
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Alzheimer's Disease
An Investigation Into the Feasibility of Beetroot Juice Supplementation in People Living With Alzheimer's Disease.
The goal of this clinical trial is to learn if taking a beetroot juice supplement will work in people living with Alzheimer's disease.
- Trial name
- OMNI (NCT07258004)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of the West of Scotland
HNSCC, OSCC
Objective Response Rate of Ivonescimab With Chemotherapy in Locally Advanced Resectable Oral and Oropharyngeal Squamous Cell Carcinoma
To investigate the neoadjuvant chemoimmunotherapy regimen of Ivonescimab combined with chemotherapy (Paclitaxel plus Cisplatin/Carboplatin) for the treatment of locally advanced resectable oral squamous cell carcinoma and…
- Conditions
- HNSCC, OSCC, OPSCC, Ivonescimab
- Trial name
- NCT07686575
- Testing
- Ivonescimab（AK112，a PD-1/VEGF bispecific antibody）
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Peri-Implantitis
Peri-implantitis and MMP-8
Peri-implantitis is defined as the pathological condition around dental implants characterized by inflammation in the peri-implant mucosa and progressive bone loss, eventually leading to implant loss.
- Trial name
- NCT05711407
- Testing
- Gene Polymorphisms of MMP-8
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki