Clinical trials: Oral Pain
Trigeminal Neuralgia
A Study to Validate a Pain Diary for Patient With Trigeminal Neuralgia
The aim of the study is to establish the validity of a patient reported diary in TN . The following objectives have been identified: 1.
- Trial name
- NCT06019338
- Testing
- Pain Diary use
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Noema Pharma AG
Dental Pain, Surgery, Dental
Dental Pain (Following Third Molar Tooth Extraction) Study
The purpose of this study is to evaluate the effectiveness of GW406381 (a COX-2 inhibitor) in treating the signs and symptoms of dental pain following third molar tooth extraction.
- Trial name
- NCT00114049
- Testing
- GW406381
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- GlaxoSmithKline
Migraine, Headache
Bioequivalence Study to Compare Ibuprofen/ Paracetamol Tablets (200mg Ibuprofen/ 500mg Paracetamol) Versus Nuromol® Tablets (200mg Ibuprofen/ 500mg Paracetamol)
Randomized, two-way, two-period, single oral dose, open-label, crossover, bioequivalence study to compare Ibuprofen/ Paracetamol tablets (200mg Ibuprofen/ 500mg Paracetamol) versus Nuromol® tablets (200mg Ibuprofen/ 500mg…
- Conditions
- Migraine, Headache, Backache
- Trial name
- NCT06180070
- Testing
- Ibuprofen/ Paracetamol tablets, Nuromol® tablets
- Where
- Jordan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Postsurgical Pain Due to Third Molar Extraction
An Analgesic Study to of V117957 for the Treatment of Postsurgical Pain Due to Third Molar Extraction
The primary objective of this study is to assess the analgesic properties of an oral dose of V117957 4.5 mg aqueous suspension in the third molar extraction model
- Trial name
- NCT01900795
- Testing
- V117957, Ibuprofen
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Purdue Pharma LP
Quality of Life, Breakthrough Cancer Pain
Observational Registry Study of Quality of Life When Treating BTcP With Abstral
This Observational Registry study is designed to collect self-reported Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) Access program-enrolled patient experience with breakthrough…
- Trial name
- RELIEF (NCT01936636)
- Testing
- Fentanyl
- Where
- 36 sites in United States
- Volunteers
- 164 people
- Sponsor
- Galena Biopharma, Inc.
Migraine
ZAP, US. Zomig for Appropriate for Primary Care
The purpose of this study is to determine how useful and effective the use of ZOMIG-ZMT™ (zolmitriptan) 5.0 mg and ZOMIG® Nasal Spray (zolmitriptan) 5.0 mg is for patients, in treating migraine over a period of 6 months
- Trial name
- NCT00637286
- Testing
- Zolmitriptan
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Colic
Study to Evaluate Efficacy and Safety of Oral Doses of Hyoscine Butylbromide for the Treatment of Occasional Abdominal Pain, Cramping, and Discomfort
Study to determine whether hyoscine butylbromide can provide adequate symptomatic relief of a single episode - defined as lasting not longer than 1 day - and multiple episodes of abdominal pain or discomfort associated with…
- Trial name
- NCT02242292
- Testing
- Hyoscine butylbromide
- Volunteers
- 527 people
- Sponsor
- Boehringer Ingelheim
Pain
PK Evaluation of a Nanoformed Oral IR Piroxicam Tablet in Healthy Subjects
Piroxicam is a nonsteroidal anti-inflammatory medication and currently used to treat pain and inflammation caused by osteoarthritis or rheumatoid arthritis.
- Trial name
- NCT05104931
- Testing
- Nanoformed Piroxicam IR Tablet, Felden (piroxicam) Tablets, Brexidol (piroxicam) Tablets
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nanoform Finland Plc
Pain
Investigation of Rate+Extent of Excretion of Radioactivity in Urine+Faeces After Oral Administration of [14C]AZD1386
The aim of this study is to get information about absorption, distribution, metabolism and excretion as well as the tolerability and safety of AZD1386 in healthy male volunteers.
- Trial name
- NCT00832169
- Testing
- AZD1386
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Migraine, Headache
Adjunctive Treatment of Chronic Migraine Using an Oral Dental Device
Single blinding study comparing FDA cleared device for prevention of medically diagnosed migraine pain to placebo.
- Trial name
- NCT04871581
- Testing
- NTI-tss
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ChairsideSplint.com
Mucositis, Solid Tumors
Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
The purpose of this research study is to test the safety and effectiveness of palifermin to determine if weekly doses can be safely administered to reduce the incidence (occurrence of), duration (length of time) and severity…
- Conditions
- Mucositis, Solid Tumors, Stomatitis, Head and Neck Cancer
- Trial name
- NCT00101582
- Testing
- palifermin, cisplatin chemotherapy, Radiotherapy
- Volunteers
- 188 people
- Sponsor
- Swedish Orphan Biovitrum
Migraine, Pain
A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain
A Study to Assess the Efficacy and Safety of Oral CL-H1T in the Treatment of Acute Migraine Pain.
- Conditions
- Migraine, Pain, Nausea, Vomiting
- Trial name
- NCT03877718
- Testing
- Arm 1: CL-H1T, Arm 2: CL-H1T, Arm 3: Sumatriptan Succinate 100 mg capsule
- Where
- 3 sites in United States
- Volunteers
- 475 people
- Sponsor
- Charleston Laboratories, Inc
Chronic Pain
Effectiveness, Safety, and Tolerability Study of Oxymorphone Immediate Release (IR) Oral Liquid in Opioid Tolerant Pediatric Subjects
The purpose of this study is to evaluate the effectiveness, tolerability, and safety of oxymorphone immediate release (IR) oral liquid as an analgesic in pediatric subjects having severe to moderate chronic pain.
- Trial name
- NCT01206907
- Testing
- oxymorphone IR
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Chronic Pain, Nociceptive Pain
A Placebo-Controlled, Two-Part Study, Oral Dose to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of CNTX-6970 in Healthy Subjects
A Phase 1, placebo-controlled, two part study with either single dose or multiple increasing oral dose to evaluate the safety, pharmacokinetics, and pharmacodynamics of CNTX-6970 in healthy subjects.
- Trial name
- NCT03787004
- Testing
- CNTX-6970
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Neuropathic Pain, Mechanical Hypersensitivity
AZD2066 Neuropathic Pain - Mechanical Hypersensitivity
The purpose of this study is to investigate if 28 days of treatment with AZD2066 compared to placebo can relieve the pain arising from the nervous system when the patients are touched by something that should not cause pain or…
- Trial name
- NP-MH (NCT00939094)
- Testing
- AZD2066
- Where
- 38 sites in United States
- Volunteers
- 87 people
- Sponsor
- AstraZeneca
Heart Failure, Myocardial Ischemia
PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina
This study investigates whether symptom-limited exercise capacity in ischemic cardiomyopathy patients with angina is deleteriously affected by treatment with CK-1827452.
- Conditions
- Heart Failure, Myocardial Ischemia, Angina Pectoris
- Trial name
- NCT00682565
- Testing
- CK-1827452 24mg and 6 mg iv infusion, CK-1827452 12.5mg capsule, CK-1827452 48 mg and 11 mg iv infusion
- Where
- 14 sites in Georgia, Russia
- Volunteers
- 94 people
- Sponsor
- Cytokinetics
Pain
Evaluation of the Effect of Suzetrigine (SUZ) on the Pharmacokinetics of Oral Contraceptives in Healthy Female Participants
The purpose of this study is to evaluate the effect of SUZ on the pharmacokinetics of oral contraceptives.
- Trial name
- NCT06820307
- Testing
- Suzetrigine, DRSP/EE, NGM/EE
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Dental Pain
A Study of ARRY-371797 in Subjects Undergoing Third Molar Extraction
This is a Phase 2 study designed to test the ability of investigational study drug ARRY-371797 to reduce pain in a postoperative pain model (third molar extraction), and to further evaluate the drug's safety.
- Trial name
- NCT00663767
- Testing
- ARRY-371797, p38 inhibitor; oral, Celecoxib, COX-2 inhibitor; oral
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Pfizer
Irritable Bowel Syndrome
Administration of a Molecular Complex of Resins, Polysaccharides and Polyphenols in Irritable Bowel Syndrome.
This study is aimed to investigate the efficacy and safety of Colilen IBS, a Medical Device made of natural substances, even when taken in addition to other therapies, for the treatment of Irritable Bowel Syndrome.
- Trial name
- NCT05016024
- Testing
- Colilen IBS
- Where
- 7 sites in Germany, Italy
- Volunteers
- 71 people
- Sponsor
- Aboca Spa Societa' Agricola
Acute Pain
A Phase 1 Dose Escalation Study of Oral VX-708 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple ascending doses of VX-708 in healthy participants.
- Trial name
- NCT05347394
- Testing
- VX-708
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated