Clinical trials: Oral Soft Tissue Conditions
Advanced Solid Tumors, Sarcoma
Phase 1, First-in-human Study of Oral TP-1287 in Patients with Advanced Solid Tumors
TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib. This is a Phase 1, open-label, dose-escalation, dose-expansion, safety, pharmacokinetics, and pharmacodynamic study, with a purpose of determining the maximum…
- Conditions
- Advanced Solid Tumors, Sarcoma, Ewing Sarcoma, Dedifferentiated Liposarcoma
- Trial name
- NCT03604783
- Testing
- TP-1287
- Where
- 10 sites in United States
- Volunteers
- 74 people
- Sponsor
- Sumitomo Pharma America, Inc.
Uterine Fibroids, Heavy Menstrual Bleeding
Efficacy and Safety of BG2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids.
The primary objective of this study is to demonstrate the superior efficacy versus placebo of BG2109 alone and in combination with add-back therapy for the reduction of heavy menstrual bleeding associated with uterine fibroids in…
- Trial name
- NCT05620355
- Testing
- BG2109, Add-back therapy
- Where
- 29 sites in China
- Volunteers
- 312 people
- Sponsor
- Bio Genuine (Shanghai) Biotech Co., Ltd.
Kidney Cancer, Leukemia
Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell Transplantation
RATIONALE: Traumeel® S (a mouth rinse) may be effective in preventing or decreasing the severity of oral mucositis caused by chemotherapy in young patients who are undergoing stem cell transplantation.
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Neuroblastoma
- Trial name
- NCT00080873
- Testing
- Traumeel S
- Where
- 44 sites in United States, Australia and 2 more
- Volunteers
- 195 people
- Sponsor
- Children's Oncology Group
Brain and Central Nervous System Tumors, Chordoma
Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancer
RATIONALE: Polyvinylpyrrolidone-sodium hyaluronate gel may lessen the pain of oral mucositis, or mouth sores, in patients undergoing treatment for cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chordoma, Kidney Cancer, Leukemia
- Trial name
- NCT00349024
- Testing
- polyvinylpyrrolidone-sodium hyaluronate gel
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)
A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies
The purpose of this trial is to assess the efficacy, safety, tolerability, biologic activity, and pharmacokinetics of AMN107 in six groups of patients with one of the following conditions: Relapsed/refractory Ph+ Acute…
- Conditions
- Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive), Hypereosinophilic Syndrome, Systemic Mastocytosis
- Trial name
- NCT00109707
- Testing
- Nilotinib
- Where
- 101 sites in United States, Australia and 20 more
- Volunteers
- 507 people
- Sponsor
- Novartis Pharmaceuticals
Wound Surgical, Wound Heal
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part I
The purpose of the present study is to observe and compare -through a biomolecular analysis- the differences in the gene expression and cellular behavior in the early wound healing process -24 hours after injury- between the…
- Conditions
- Wound Surgical, Wound Heal, Oral Soft Tissue Conditions
- Trial name
- NCT04202822
- Testing
- Oral soft tissues biopsies
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Roma La Sapienza
CML, GIST
Distress, Medication Adherence and Care Needs in Patients With CML and GIST Receiving Oral Targeted Therapy
Background: Long-term or life-long oral targeted therapy might also increase patients' distress, influencing patients' cognitive and life activity function, medication adherence and related care needs.
- Trial name
- NCT03880617
- Where
- Taiwan
- Volunteers
- 297 people
- Sponsor
- National Taiwan University Hospital
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Oral Soft Tissue Conditions
A Comparative Clinical Study Between a Collagen Matrix and Collagen Membrane as Wound Protection During Ridge Preservation ARP
Patients in need of extraction of two teeth in combination with alveolar ridge preservation will be invited to participate in intra-subject RCT on ARP. Prior to surgery, a small-field low-dose CBCT is taken.
- Trial name
- ARP (NCT06029322)
- Testing
- Socket seal after alveolar ridge preservation
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Advanced Malignant Neoplasm, Castleman Disease
Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease
This phase I trial studies the side effects and best dose of bevacizumab and temsirolimus alone or in combination with valproic acid or cetuximab in treating patients with a malignancy that has spread to other places in the body…
- Conditions
- Advanced Malignant Neoplasm, Castleman Disease, Digestive System Carcinoma, Erdheim-Chester Disease
- Trial name
- NCT01552434
- Testing
- Bevacizumab, Cetuximab, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- M.D. Anderson Cancer Center
Advanced Solid Tumors
Study of Oral Darinaparsin in Patients With Advanced Solid Tumors
This study is a Phase I, dose escalation study of oral darinaparsin for the treatment of advanced solid tumors. Eligible patients could have received any amount of previous therapy.
- Trial name
- NCT01139346
- Testing
- darinaparsin
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Alaunos Therapeutics
Acute Oroantral Communication
Buccal Periosteal Inversion Flap vs Buccal Advancement Flap for Acute Oro-Antral Communication Closure
This prospective randomized controlled clinical trial will compare the Buccal Periosteal Inversion Flap (BUPI) with the Buccal Advancement Flap (BAF) for the primary surgical closure of acute oro-antral communications (OAC)…
- Trial name
- NCT07884331
- Testing
- Buccal Periosteal Inversion Flap, Buccal Advancement Flap
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Graz
Gingival Recession, Localized
Theravex Oral and Theravex Tissue Care Plus in the Healing Process of Mucogingival Surgery
This clinical study assesses the efficacy of two novel bioactive solutions, Theravex Oral and Theravex Tissue Care Plus, in enhancing soft tissue healing after periodontal surgery.
- Trial name
- NCT07430670
- Testing
- Modified Free Gingival Graft (M-FGG), Theravex Bioactive Solutions (Tissue Care Plus and Oral)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Solid Tumors, CNS Tumors
Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options
This is an open-label, Phase 1/2 multicenter dose escalation study in pediatric patients with relapsed or refractory extracranial solid tumors (Phase 1), with additional expansion cohorts (Phase 2) in patients with primary brain…
- Trial name
- STARTRK-NG (NCT02650401)
- Testing
- Entrectinib
- Where
- 26 sites in United States, Canada and 7 more
- Volunteers
- 69 people
- Sponsor
- Hoffmann-La Roche
Alveolar Bone Loss, Sinus Pneumatization
Microarchitecture of the Augmented Bone Following Sinus Elevation
In this prospective randomized clinical study sinus floor elevation procedures are preformed using different biomaterials with the lateral window technique.
- Conditions
- Alveolar Bone Loss, Sinus Pneumatization, Edentulous; Alveolar Process, Atrophy
- Trial name
- MAB (NCT04136509)
- Testing
- sinus floor elevation, bone core biopsy, dental implant placement
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Semmelweis University
Cellulitis
Predictors of Oral Antibiotic Treatment Failure in Emergency Department Patients With Cellulitis
The term cellulitis is a medical term describing a bacterial infection of the skin and tissues beneath the skin. Although it is usually easily treated with antibiotics given either orally or through a vein (intravenously)…
- Trial name
- NCT02230813
- Where
- 3 sites in Ireland
- Volunteers
- 152 people
- Sponsor
- Royal College of Surgeons, Ireland
Impacted Mandibular Third Molar
Cyanoacrylate Adhesive in Impacted Mandibular Third Molars Surgery
The goal of this randomized clinical trial is to evaluate whether cyanoacrylate tissue adhesive can improve postoperative outcomes compared with conventional silk sutures in patients undergoing surgical removal of impacted…
- Trial name
- NCT07445724
- Testing
- cyanoacrylate tissue adhesive, Silk Sutures
- Where
- 2 sites in Vietnam
- Volunteers
- 23 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Uterine Fibroids, Heavy Menstrual Bleeding
Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids
The primary objective of this study is to demonstrate the superior efficacy versus placebo of OBE2109 alone and in combination with add-back therapy for the reduction of heavy menstrual bleeding associated with uterine fibroids…
- Trial name
- PRIMROSE 2 (NCT03070951)
- Testing
- OBE2109, Add-back
- Where
- 96 sites in United States, Bulgaria and 7 more
- Volunteers
- 511 people
- Sponsor
- ObsEva SA
Neoplasm Metastasis, Sarcoma
Adjuvant Oral Decitabine and Tetrahydrouridine With or Without Celecoxib in People Undergoing Pulmonary Metastasectomy
Background: Most patients who have surgery for cancer that has metastasized (spread) to the lungs later get more metastases that cannot be treated with surgery or chemotherapy.
- Conditions
- Neoplasm Metastasis, Sarcoma, Neoplasms, Germ Cell and Embryonal, Melanoma
- Trial name
- NCT02839694
- Testing
- decitabine (DAC), Tetrahydrouridine (THU), Celecoxib
- Sponsor
- National Cancer Institute (NCI)
Oral Soft Tissue Conditions, Drug Effect
Flurbiprofen Tablet vs Spray In Oral Soft Tissue Wounds
The amount of active ingredient in tablet form of flurbiprofen is higher than that in the oral spray form. Therefore, based on the hypothesis that the side effects that may occur depending on the dose can be reduced, this…
- Conditions
- Oral Soft Tissue Conditions, Drug Effect, Drug Use
- Trial name
- NCT06238154
- Testing
- Flurbiprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University