Clinical trials: Organ Donation
Chronic Graft Versus Host Disease, Chronic GVHD
Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
This research study is a Phase I clinical trial, which tests the safety of an investigational combination of IL-2 plus donor anti-inflammatory Treg cells and also tries to define the appropriate dose of the investigational…
- Conditions
- Chronic Graft Versus Host Disease, Chronic GVHD, Complications of Organ Transplant Stem Cells
- Trial name
- NCT01937468
- Testing
- Treg-enriched infusion, Interleukin-2
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Dana-Farber Cancer Institute
Kidney Transplantation
CMV-associated Immunomodulation in Renal Transplant Patients
Cytomegalovirus (CMV) infection has been associated with an increased risk of bacterial, fungal and viral infections in solid organ transplant recipients.
- Trial name
- IMMCMV (NCT06976008)
- Testing
- blood sampling
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cell-mediated Immune Response
Performance Comparison of QuantiFERON Monitor in Solid Organ Transplant Recipients
To compare the performance of the QuantiFERON Monitor assay against existing methodology.
- Trial name
- NCT02416414
- Testing
- QuantiFERON Monitor Assay, Existing methodology
- Where
- 4 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- QIAGEN Gaithersburg, Inc
Infection in Solid Organ Transplant Recipients
Pneumococcal Conjugate Vaccine 13 (Prevnar13®) in Children Who Are Solid Organ Transplant Recipients (SOT)
The purpose of this study is to determine the safety and long-term immunogenicity of the 13-Valent Pneumococcal Conjugate vaccine in children who are solid organ transplant recipients.
- Trial name
- NCT01527591
- Testing
- Pneumococcal Conjugate Vaccine 13 (PCV13)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Los Angeles
Kidney Transplantation
Testing the Effect of KnowMAP (Knowledge Management for Renal Transplant Recipients). A Randomized Controlled Study
A randomized controlled study (RCT) aiming to test the effect of a new health literacy intervention for renal transplant recipients, KnowMAP (knowledge management for renal transplant recipients).
- Trial name
- KnowMAP (NCT04296955)
- Testing
- Motivational interview as a new health communication intervention
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Renal Transplantation
Efficacy and Safety of FTY720 in de Novo Adult Renal Transplant Recipients
This study will evaluate the safety and efficacy of FTY720 combined with cyclosporine and corticosteroids in patients receiving a kidney transplant.
- Trial name
- NCT00239902
- Testing
- FTY720
- Volunteers
- 396 people
- Sponsor
- Novartis Pharmaceuticals
Lymphoproliferative Disorder
Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation
RATIONALE: Drugs used in chemotherapy such as cyclophosphamide, prednisone, and methylprednisolone use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00066469
- Testing
- rituximab, cyclophosphamide, methylprednisolone
- Where
- 78 sites in United States, Australia and 2 more
- Volunteers
- 55 people
- Sponsor
- Children's Oncology Group
Leukemia, Lymphoma
Immunotherapy for Lymphoproliferative Diseases Associated With Epstein-Barr Virus in Patients Who Have Undergone Organ Transplants
RATIONALE: Donor lymphocytes that have been exposed to Epstein-Barr virus may be able to help the body kill cancers associated with this virus.
- Trial name
- NCT00002956
- Testing
- allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
EBV Viremia, CMV Viremia
25BT056: Basket Study of Viral Cytotoxic T Lymphocytes
This study is evaluating the safety and effectiveness of virus-specific cytotoxic T lymphocytes (vCTLs) for treating difficult-to-control viral infections caused by cytomegalovirus (CMV), adenovirus (ADV), Epstein-Barr virus…
- Conditions
- EBV Viremia, CMV Viremia, BK Viremia, Adenovirus
- Trial name
- NCT07873970
- Testing
- Virus-Specific Cytotoxic T Lymphocytes (vCTLs)
- Volunteers
- 35 people
- Sponsor
- Children's Hospital of Philadelphia
Transplantation, Telemedicine
Image Transmission Applied to Organ Transplant: Before-after Study of the Effectiveness of the Device
In the complex process of organ transplant, two of the major steps are: 1. evaluation of the organs of potential donors in health institutions: 2.
- Trial name
- NCT03201224
- Testing
- "After" Group
- Where
- France
- Volunteers
- 20,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Organ Donation, Health Behavior
University Student Intervention to Increase Organ Donation
The purpose of this study is to determine the effect of brief organ donation video interventions on consent for organ donation among college and university students.
- Trial name
- NCT01969864
- Testing
- HRSA Video Intervention, PI Video Intervention, CDC Health Website Intervention
- Where
- 3 sites in United States
- Volunteers
- 2,261 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Transplantation, Pulmonary Diseases
Specific Genotypes/Phenotypes of Pneumocystis Jirovecii in Solid Organ Transplant Recipients: Potential Involvement of Mycophenolic Acid
To determine the presence of IMDPH mutants of Pneumocystis jirovecii in solid organ transplant recipient with prior exposition to mycophenolic acid.
- Trial name
- IMPDH (NCT05452148)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Tissue and Organ Procurement
Communication Regarding Organ and Tissue Donation in Intensive Care
The overarching aim of this study is to examine the process of organ donation decision-making and to determine whether changes in requesting practices change rates of consent for donation, and other family-based outcomes.
- Trial name
- COMFORT (NCT01922310)
- Testing
- Communication intervention
- Where
- 10 sites in Australia
- Volunteers
- 417 people
- Sponsor
- NSW Organ and Tissue Donation Service
Solid Organ Transplantation
Biomarkers and Inflammation in Solid Organ Transplantation: Relationship With Short- and Long-Term Outcomes
This is a prospective, tissue-based, low-risk, non-pharmacological study that will include adult patients undergoing solid organ transplantation (heart, liver, lung, kidney) followed at the following Units of the IRCCS Azienda…
- Trial name
- Bio-Trap (NCT06774339)
- Where
- 3 sites in Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COVID-19, SARS-CoV-2 Infection
Immune Response to Third Dose of COVID-19 Vaccine in Solid Organ Transplant
The Coronavirus Disease 2019 (COVID-19) pandemic has claimed over 5 million lives globally. Fortunately, a substantial and growing number of SARS-CoV-2 vaccines with very high efficacy have been developed, manufactured, and…
- Conditions
- COVID-19, SARS-CoV-2 Infection, Solid Organ Transplant, Vaccine Response Impaired
- Trial name
- NCT05124509
- Testing
- Three doses of SARS-CoV-2 BNT162b2 vaccine (observational), Two doses of CoronaVac and one dose of BNT162b2 SARS-CoV-2 vaccine (observational)
- Where
- Chile
- Volunteers
- 147 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Tissue and Organ Procurement, Health Behavior
Community Trial to Enhance Organ Donation
The purpose of this study is to determine the effect of a 5-minute video intervention regarding organ donation and transplantation on increasing the number of organ donor cards signed in Northeastern Ohio Bureau of Motor Vehicles…
- Trial name
- NCT00870506
- Testing
- video
- Where
- United States
- Volunteers
- 973 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Control, Behavior
Evaluating Attitudes Towards Organ Donation in Singapore
One survey is conducted. Exploring the effect of different messages on family members' decision making on organ donation.
- Trial name
- NCT03216213
- Testing
- Frame, Norms
- Where
- Singapore
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Organ Transplantation, Mobile Applications
The Effect of Education on Quality of Life, Adherence to Immunosuppressive Therapy and Symptom Control in Organ Transplant Patients
Organ transplantation is the most effective method for treating end-stage organ failure and allows patients on the verge of death to continue living.
- Conditions
- Organ Transplantation, Mobile Applications, Nursing
- Trial name
- NCT07288918
- Testing
- Mobile application installation, Providing teaching booklets, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ondokuz Mayıs University
Organ Donation
Mechanisms of Nudges on Families' Decision-Making Process
As part of a larger study, participants are told to read 1 out of 4 anecdotes depicting an organ donation scenario where they are required to make a decision on behalf of their mother who has just suffered an accident.
- Trial name
- NCT03816241
- Testing
- Frame, Norms
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Opt Out, Opt In
Evaluation of Attitudes Towards Organ Donation in Individualistic or Collectivistic Countries
People make decisions every day, both for themselves and on behalf of others. In the case of organ donations, despite the opt-out systems used in Singapore where the default is a presumed consent on the part of the individual…
- Conditions
- Opt Out, Opt In, Opt Neutral
- Trial name
- NCT03351881
- Testing
- Description of Organ Donation Policy
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College