Clinical trials: Organ Failure
Sepsis
Correlation Between PTP1B Expression and Organ Failure During Sepsis
Despite major advances in the treatment and understanding of the pathophysiological mechanisms, mortality of severe sepsis remains high, ranging from 25 to 50%.
- Trial name
- SEPP1B (NCT02295514)
- Testing
- PTP1B dosage
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Rouen
Pelvic Organ Prolapse
Do Patients With Early Post Operative Recurrence of Pelvic Organ Prolapse Have a Genetic Predisposition?
The objective is to explore the genetic predisposition to early pelvic organ prolapse after adequate surgical repair by exploring the association between pelvic organ prolapse recurrences and certain polymorphisms.
- Trial name
- NCT01614587
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Atlantic Health System
Cardiac Valve Disease, Coronary Artery Disease
The Val-CARD Trial
The Val-CARD trial aims to answer the question: "Does the drug sodium valproate reduce complications affecting the heart and kidneys in patients having heart operations?" Sodium valproate is a drug commonly used in the treatment…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Organ Failure, Multiple
- Trial name
- Val-CARD (NCT03825250)
- Testing
- Sodium Valproate
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Leicester
Sepsis, Critical Illness
Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children
Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy.
- Conditions
- Sepsis, Critical Illness, MODS
- Trial name
- CELS (NCT03654287)
- Testing
- Treatment
- Where
- China
- Sponsor
- Guoping Lu
Localized Infection, Sepsis
The Procalcitonin and Survival Study
This is a randomised, single blinded, multicentre trial to evaluate whether daily procalcitonin (PCT) measurements and immediate diagnostic and therapeutic responses to abnormal values and day-to-day changes can reduce the…
- Conditions
- Localized Infection, Sepsis, Multiple Organ Failure
- Trial name
- PASS (NCT00271752)
- Testing
- Earlier therapeutic changes regarding infection
- Where
- 9 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Danish Procalcitonin Study Group
Septic Shock, Multiple Organ Failure
Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study
Septic shock is defined as a subset of sepsis with severe metabolism alterations, leading to organ failure. Septic shock is associated with a high mortality, around 40% according to the SEPSIS 3 definition.
- Trial name
- MEFDASE (NCT04288635)
- Testing
- Whole blood samples
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Angers
Organ Failure, Multiple
Impact of Fourier Transform Infrared Spectroscopy (FTIRS) in ICUs
This study will assess the impact of FTIRS typing on the spread of ESBL-E in intensive care units
- Trial name
- ECLA'IR (NCT05872152)
- Testing
- FTIR results
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Caen
Respiratory Failure, Sepsis
Electric Acupuncture for ICU-acquired Weakness in Mechanical Ventilation Patients
Intensive care unit acquired weakness (ICU-AW) is common and dramatically affect recovery. The purpose of this study is to determine whether electric acupuncture therapy is effective in the treatment of ICU-AW especially in the…
- Conditions
- Respiratory Failure, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- EA-ICUAW (NCT02204215)
- Testing
- electric acupuncture, conservative
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Jiangsu Province Hospital of Traditional Chinese Medicine
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Hemoperfusion Efferon LPS During Cardiac Surgery Using Cardiopulmonary Bypass
More than 1 million people undergo cardiac surgery each year worldwide. Cardiac surgeries still in most cases require cardiopulmonary bypass, use of myocardial protection against aortic clamping and creation of cardioplegic…
- Trial name
- NCT06659289
- Testing
- Efferon LPS
- Where
- Russia
- Volunteers
- 14 people
- Sponsor
- Efferon JSC
COVID
Mechanisms of Multi-organ Failure in COVID-19
In the United Kingdom, there are currently 138,000 confirmed patients with coronavirus, causing 18,738 deaths. Whilst the disease may be mild in the majority of patients, a significant proportion of patients require intensive…
- Trial name
- NCT04399603
- Testing
- no intervention-mechanistic study
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Imperial College London
Multiple Trauma
Danger Response in Polytrauma Patients
The NTF_PT_2014 multicenter study aims to collect, store, and analyse plasma and serum from polytrauma-patients (injury severity score ≥25) and corresponding clinical data to address 1) how trauma modulates the release of danger…
- Trial name
- NTF-PT (NCT02682550)
- Testing
- blood drawing
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Trauma, Inflammation
Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Trauma and major operation are associated with an excessive inflammation reaction due to tissue injury. This overwhelming immune response is considered to be a major risk factor in the pathogenesis of late inflammatory…
- Conditions
- Trauma, Inflammation, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- CAESAR (NCT01275976)
- Testing
- C1-esterase inhibitor, Saline 0.9%
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- UMC Utrecht
Septic Shock
Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure.
The goal of this phase 2, multicenter, randomized, controlled study is to evaluate the effect of albumin treatment on B cell and other immune cell gene exptression in adults with septic shock.
- Trial name
- ALBUMIM (NCT05645887)
- Testing
- Human albumin, Saline solution
- Sponsor
- Albimmune SL
Blood Pressure Determination, Hemodynamic Monitoring
Continuous Vs Intermittent Non Invasive Blood Pressure Monitoring in Preventing Post Operative Organ Failure
Continuous non-invasive arterial pressure monitoring has the potential to decrease the duration of intraoperative hypotension and hypertension compared to conventional intermittent blood pressure monitoring. Chen et al.
- Conditions
- Blood Pressure Determination, Hemodynamic Monitoring, Postoperative Complications
- Trial name
- NiMon (NCT05496322)
- Testing
- Continuous Non Invasive Blood Pressure Monitoring, Intermittent Non Invasive Blood Pressure Monitoring
- Where
- Italy
- Volunteers
- 1,267 people
- Sponsor
- University of Messina
Multiple Organ Failure, Sepsis
Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients
The purpose of this study is to determine the pharmacokinetic properties of two different dosage regimens of intravenous vitamin C in patients admitted to the Intensive Care Unit with life-threatening illness.
- Conditions
- Multiple Organ Failure, Sepsis, Systemic Inflammatory Response Syndrome, Trauma
- Trial name
- NCT02455180
- Testing
- Ascorbic Acid
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Brain Damage Due to Hypoxia, Organ Donors
Endothelial Glycocalyx Damage in Brain Death Organ Donors
The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program.
- Conditions
- Brain Damage Due to Hypoxia, Organ Donors, Organ Transplant Failure or Rejection
- Trial name
- NCT05609123
- Testing
- Endothelial glycocalyx damage assessment
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Liver Transplant; Complications, Liver Transplant Rejection
Mortality, Morbidity and Risk Factors of Liver Retransplantation
This study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. Bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a…
- Conditions
- Liver Transplant; Complications, Liver Transplant Rejection, Liver Transplant Failure, Liver Diseases
- Trial name
- NCT04789213
- Testing
- Liver Transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Memorial Bahçelievler Hospital
Acute Pancreatitis (AP)
Heparin to Prevent Organ Failure in Acute Pancreatitis
This clinical trial is designed to evaluate whether adding a standard blood-thinning medication, Unfractionated Heparin, to standard hospital care can help prevent severe organ failure in patients admitted with acute…
- Trial name
- NCT07609771
- Testing
- Unfractionated heparin, Standard supportive care
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Allied Hospital Faisalabad
Type A Aortic Dissection, Organ Failure, Multiple
Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic Dissection
The goal of this multicenter, double-blind, randomized controlled trial is to learn if sivelestat sodium (Siv) can protect the organ function in patients suffered operation for acute type A aortic dissection.
- Trial name
- STOP (NCT07156656)
- Testing
- Conventional treatment, Sivelestat sodium
- Where
- 6 sites in China
- Volunteers
- 236 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiac Valve Disease, Coronary Artery Disease
The PRE-OP ENERGY Trial
The PRE-OP ENERGY Trial proposes to test the overarching hypothesis that a pre-surgery high energy diet will protect patients against organ damage during cardiac surgery with cardiopulmonary bypass.
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Organ Failure, Multiple
- Trial name
- NCT04015973
- Testing
- High energy diet
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Leicester