Clinical trials: Organ Failure
Human Immunodeficiency Virus, End Stage Renal Disease
Tulane Abdominal Transplant Institute (TATI) of Solid Organ Transplantation of HIV-Positive Recipients From HIV-Positive Donors
The U.S. Department of Health and Human Services (HHS), through the National Institutes of Health (NIH), published Final Human Immunodeficiency Virus (HIV) Organ Policy Equity (HOPE) Act Safeguards and Research Criteria for…
- Trial name
- NCT05159466
- Testing
- Kidney transplant
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tulane University
Type 2 Diabetes, Pre Diabetes
Multi-morbidity Screening in People With Type 2 Diabetes and Pre Diabetes
People with type 2 diabetes are at risk of complications linked with high blood sugars and these are monitored for in healthcare appointments.
- Conditions
- Type 2 Diabetes, Pre Diabetes, Obstructive Sleep Apnea, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT06053177
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- University of Liverpool
Organ Failure, Multiple
Evaluation of Corrected Carotid Flow Time Variations During Passive Leg Lift to Predict Response to Filling.
Patients hospitalized in intensive care often require intravenous administration of fluid in order to optimize the functioning of the heart and thus ensure perfusion of vital organs such as the kidneys, the brain or the digestive…
- Trial name
- CAROT (NCT04732481)
- Testing
- passive leg lift test
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier de Cornouaille
Critical Illness, Multiple Organ Failure
Intestinal-Specific Organ Function Assessment (iSOFA Study)
Importance of gastrointestinal (GI) function in critically ill patients has been recognized, but until now there is no validated clinical tool to monitor GI dysfunction as part of multiple organ dysfunction syndrome (MODS).
- Trial name
- iSOFA (NCT02613000)
- Testing
- No intervention
- Where
- Estonia
- Volunteers
- 544 people
- Sponsor
- University of Tartu
Pulmonary Hypertension, Thromboembolism, Pulmonary
Perioperative Portal Vein Pulsatility as a Postoperative Prognostic Indicator in Pulmonary Endarterectomy
The investigators aim to evaluate the utility of portal vein pulsatility as a predictor of the composite outcome of persistent organ dysfunction plus death in patients undergoing elective or urgent pulmonary endarterectomy for…
- Conditions
- Pulmonary Hypertension, Thromboembolism, Pulmonary, Perioperative/Postoperative Complications, Venous Hypertension
- Trial name
- PVP-ETO-CPC (NCT03197792)
- Testing
- All patients
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Sepsis, Severe Sepsis
Preemptive Resuscitation for Eradication of Septic Shock
The purpose of this study is to assess the ability of an empiric resuscitation strategy compared to standard care to decrease the incidence of organ failure in normotensive sepsis patients.
- Trial name
- NCT01449721
- Testing
- Intravenous fluid
- Where
- 5 sites in United States
- Volunteers
- 142 people
- Sponsor
- Christiana Care Health Services
Multiple Organ Dysfunction Syndrome
Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection
Multiple organ dysfunction syndrome (MODS) after surgical repaire for acute type A aortic dissection(ATAAD) is a life-threatening condition.
- Trial name
- NCT03552848
- Testing
- MSC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Septic Shock, Multiple Organ Dysfunction Syndrome
Therapeutic Plasma Exchange Adsorption Diafiltration
The purpose of this study is to evaluate the efficacy of coupled therapeutic plasma exchange adsorption diafiltration (PEAF )for treating septic shock with multiple organ dysfunction syndrome patients in ICU.
- Trial name
- PEAF (NCT03589378)
- Testing
- PEAF
- Where
- 12 sites in China
- Volunteers
- 168 people
- Sponsor
- Shenzhen Second People's Hospital
Renal Failure, End Stage
The ONE Study M Reg Trial
To collect evidence of the safety of administering donor-derived regulatory macrophage (M reg) preparations to living-donor renal transplant recipients in the context of an international European Union funded consortium aimed at…
- Trial name
- ONEmreg12 (NCT02085629)
- Testing
- Donor M reg (Mreg_UKR)
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- University of Regensburg
SIRS, Sepsis
NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock
The purpose of this study is to determine the course of NT-proBNP plasma concentrations in the context of confounding parameters in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- SIRS, Sepsis, Shock, Critically Ill
- Trial name
- NICUPS (NCT00736723)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm
Sepsis
Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis
In an effort to better understand the interaction between the different mediators, the investigators propose to examine the time course of mediators, the indexes of organ injury and the coagulation cascade.
- Trial name
- Histone (NCT01012115)
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Oklahoma
Heart Transplant Failure and Rejection
A Clinical Study of Association Between Postoperative Dyslipidemia and Organ Rejection in Transplant Patients
Abnormal lipid metabolism is a common complication after organ transplantation, with pathological changes in lipid parameters occurring in approximately 60-80% of cardiac transplant recipients receiving triple immunotherapy with…
- Trial name
- NCT05994274
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critical Illness, Multi Organ Failure
Parathyroid Hormone Kinetics During CRRT
The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation…
- Conditions
- Critical Illness, Multi Organ Failure, Renal Failure, Circulatory Failure
- Trial name
- NCT03873675
- Testing
- parathyroid hormone
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Acute Decompensated Heart Failure
Short-term Mortality Prediction by the SOFA Score in Acute Decompensated Heart Failure
Data on the use of sequential organ failure assessment (SOFA) in patients with cardiovascular disease are increasing. Several studies demonstrated that the SOFA score can identify short-term mortality in patients with acute…
- Trial name
- NCT06354426
- Where
- Vietnam
- Volunteers
- 216 people
- Sponsor
- Hanoi Heart Hospital
Mechanically-ventilated Neonates With Single-organ Respiratory Failure
Dexmedetomidine in Mechanically Ventilated Neonates With Single-Organ Respiratory Failure.
Clinical experience with dexmedetomidine in the paediatric population is limited. Critical illness can affect drug pharmacokinetics and -dynamics; the investigators cannot simply extrapolate adult data for use in children but the…
- Trial name
- NEODEX (NCT01266252)
- Testing
- Dexmedetomidine
- Where
- 3 sites in Belgium
- Volunteers
- 35 people
- Sponsor
- University Hospital, Ghent
Multiorgan Failure, Perfusion; Complications
NIRS and DO2i Correlation
This study evaluates the association between near infrared spectroscopy (NIRS) and indexed oxygen delivery (DO2i) and their possible correlation with postoperative organ failure.
- Trial name
- NCT03281707
- Testing
- NIRS, DO2i
- Volunteers
- 50 people
- Sponsor
- Centro Cardiologico Monzino
Diffuse Cutaneous Systemic Sclerosis
A Safety and Efficacy Study of FCR001 in Adults With Rapidly Progressive Diffuse Cutaneous Systemic Sclerosis
This is a multicenter, open-label study to evaluate the safety and tolerability and explore the efficacy of FCR001 cell therapy in adults with rapidly progressive Diffuse Cutaneous Systemic Sclerosis (dcSSc) at risk for organ…
- Trial name
- FREEDOM-3 (NCT05098145)
- Testing
- FCR001
- Where
- United States
- Sponsor
- Talaris Therapeutics Inc.
Thoracoabdominal Aortic Aneurysm
Investigation of the Cerebrospinal Fluid and Further Tissue Samples for Biomarker Indicating Spinal Ischemia and Organ Failure in Patients With Thoracoabdominal Aortic Aneurysm
Patients with a thoracoabdominal aortic aneurysm in need of an endovascular or open operative restructuring will be asked to participate in this study.
- Trial name
- TAAA (NCT03093857)
- Testing
- Determination of biomarker
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Heart Failure
Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients
This phase II, multi-center, open-label study will evaluate the safety and efficacy of utilizing HCV-positive donors for heart transplant in HCV-negative recipients treated with sofosbuvir 400 mg / velpatasvir 100 mg (Epclusa®).
- Trial name
- TROJAN-C (NCT03383419)
- Testing
- Epclusa
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Baylor Research Institute
Sepsis, Septic Shock
Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock
The aim of this observational study is to investigate whether GDF-15 levels can predict clinical outcome in patients admitted to the intensive care unit with a diagnosis of septic shock.
- Conditions
- Sepsis, Septic Shock, Multi Organ Failure
- Trial name
- NCT06808100
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ankara City Hospital Bilkent