Clinical trials: Organ Failure
Critical Illness, Enteral Nutrition
Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients
Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly in part through an attenuation of the proinflammatory cytokine response and a Immune function.
- Conditions
- Critical Illness, Enteral Nutrition, Multiple Organ Failure, Infection Complication
- Trial name
- NCT02998931
- Testing
- Glutamin, Maltodextrin
- Where
- 2 sites in Iran
- Volunteers
- 200 people
- Sponsor
- Shahid Beheshti University
Acute on Chronic Liver Failure (ACLF)
Study About Hepatic Toxins Kinetic and Evaluation of Organ Damage in Acute on Chronic Liver Failure (ACLF) Patients
Spontaneous Observational Prospective Multicenter study of all patients admitted to Intensive Care with a diagnosis of Acute on Chronic Liver Failure (ACLF) of grade ≥ 2 for which the use of the system will be authorized…
- Trial name
- BILIVER2020 (NCT06837766)
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Multiple Organ Failure, Intensive Care Unit Syndrome
The Blood Pressure Analysis on Critically Ill Patients
The study is to explore the relationship between coefficient of variation of harmonic magnitude (HCV) and different organ failures among those critically ill patients.
- Trial name
- NCT03827369
- Testing
- ICU patient
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taoyuan General Hospital
Liver Failure, Acute on Chronic
Chinese CLIF-C Acute-on-Chronic Liver Disease and Liver Failure Study
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC (NCT02457637)
- Testing
- Standary therapy
- Where
- 16 sites in China
- Volunteers
- 2,600 people
- Sponsor
- Hai Li
Acute Kidney Injury, Fluid Overload
Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury
Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications.
- Conditions
- Acute Kidney Injury, Fluid Overload, Ultrasonography
- Trial name
- ECHO-AKI (NCT04095143)
- Testing
- Portal vein flow, Intra-renal flow, Hepatic vein flow
- Where
- 6 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Septic Shock, Multiple Organ Failure
Severe Sepsis/Septic Shock on Admission to the General Surgical ICU
Severe sepsis/septic shock are serious complications of infection with high morbidity and mortality. Recent information showed that early and aggressive resuscitation may help improving survival and outcome especially the…
- Conditions
- Septic Shock, Multiple Organ Failure, Fatal Outcome
- Trial name
- NCT01363635
- Where
- Thailand
- Volunteers
- 800 people
- Sponsor
- Mahidol University
Renal Failure, Multi Organ Failure
Uremic Toxins in the Intensive Care Unit (ICU): Patients With Sepsis
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with sepsis/multi-organ failure.
- Trial name
- NCT00752245
- Testing
- Dialysis during 4 hours, Dialysis during 6 hours, Dialysis during 8 hours
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Renal Failure Acute, Multiple Organ Failure
Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation
The purpose of this study is to assess the effectiveness and the safety of extracorporeal methods for removing mediators of systemic inflammation in patients with multiple organ dysfunction syndrome after heart and aorta surgery.
- Conditions
- Renal Failure Acute, Multiple Organ Failure, Cardiovascular Diseases
- Trial name
- NCT05182723
- Testing
- renal replacement therapy
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Multiple Organ Failure
Dynamic Monitoring of Circulating microRNA Changes in Patients With or Without Multiple Organ Failure
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without multiple organ failure. 2.
- Trial name
- NCT03059524
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
COVID-19, Post Acute Sequelae of COVID-19
COVID-19 Outcome Prediction Algorithm
Severe acute respiratory syndrome coronavirus 2-mediated coronavirus disease (COVID-19) is an evolutionarily unprecedented natural experiment that causes major changes to the host immune system.
- Conditions
- COVID-19, Post Acute Sequelae of COVID-19, Long COVID, Organ Dysfunction Syndrome, Multiple
- Trial name
- COPA (NCT05471011)
- Testing
- Blood and nasal swab sampling
- Where
- 7 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of California, Los Angeles
COVID-19 Pandemic
The Combined Usage of Clinical Physical Finding in Management of COVID 19 Patients
Physiological indicators such as blood pressure, heart rate, respiratory rate, and consciousness status of COVID-19 patients are used to apply the START (simple triage and rapid treatment, START), Modified Early Warning Score…
- Trial name
- NCT06528119
- Testing
- COVID 19 pandemic
- Where
- Taiwan
- Volunteers
- 10,000 people
- Sponsor
- St. Martin De Porress Hospital
Liver Failure, Acute on Chronic, Liver Dysfunction
A Validation Cohort for ACLF Diagnosis and Prognosis
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC-Val (NCT03641872)
- Testing
- Standary therapy
- Where
- 12 sites in China
- Volunteers
- 1,370 people
- Sponsor
- Hai Li
Pancreatitis, Acute
Resolution of Organ Injury in Acute Pancreatitis - RESORP
Acute pancreatitis (AP) is inflammation of the pancreas usually triggered by gallstones or drinking excessive alcohol. 80% of people who have an episode of AP will recover without complications.
- Trial name
- RESORP (NCT03342716)
- Where
- United Kingdom
- Volunteers
- 229 people
- Sponsor
- University of Edinburgh
Acute Respiratory Distress Syndrome Caused by COVID-19
Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19
Background: There are no proven therapies specific for Covid-19. The full spectrum of Covid-19 ranges from asymptomatic disease to mild respiratory tract illness to severe pneumonia, acute respiratory distress syndrome (ARDS)…
- Trial name
- DEXA-COVID19 (NCT04325061)
- Testing
- Dexamethasone
- Where
- 24 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Multiple Organ Failure, Critical Illness
Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial
One of the essential treatments for assisting patients in their recovery from illness is the provision of nutrition in a liquid form which is delivered into the stomach or as a fluid into the vein.
- Trial name
- NCT01847534
- Testing
- Supplemental PN, Standard Care
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 100 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Pancreatitis, Acute Necrotizing
Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis
Cytokines such as such as TNF-a, IL-1, IL-6 correlate with the severity of pancreatitis.Neuroendocrine pathways, such as the sympathetic nervous system or parasympathetic nervous system, in turn, have some impact on the immune…
- Trial name
- DHPOFFSAP (NCT02691598)
- Testing
- Infusion
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Nanjing University School of Medicine
Acute Pancreatitis, Complication
Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)
Acute pancreatitis (AP) is an inflammatory condition of the pancreas following the activated pancreatic enzymes induced by varied causes, with or without other organ(s) dysfunction.
- Conditions
- Acute Pancreatitis, Complication, Mortality Rate, Organ Failure, Multiple
- Trial name
- INDOMAP (NCT03547232)
- Testing
- Indomethacin SR
- Where
- 17 sites in China
- Volunteers
- 1,504 people
- Sponsor
- Peking Union Medical College Hospital
Liver Failure, Liver Diseases
Everolimus in de Novo Liver Transplantation: a Multicentre Randomized Study
Safety and Efficacy of Everolimus in adult de novo liver transplant recipients.
- Conditions
- Liver Failure, Liver Diseases, Liver Cirrhosis, Liver Neoplasms
- Trial name
- EPOCAL (NCT01423708)
- Testing
- Everolimus
- Where
- 7 sites in Italy
- Volunteers
- 117 people
- Sponsor
- Azienda Ospedaliera di Padova
Septic Shock
Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock.
Blood platelets play a major role in the inflammatory response. A dysregulation of platelets activation may be one of the contributors to tissue damage in critically ill patients with septic shock.
- Trial name
- PLAQSIS (NCT04080453)
- Testing
- Septic shock, Systemic Inflammatory Response Syndrome
- Where
- France
- Volunteers
- 202 people
- Sponsor
- University Hospital, Bordeaux