Clinical trials: Organ Perfusion
Liver Transplantation
Long-term Outcomes After Prolonged Dual Hypothermic Oxygenated Machine Perfusion of Donor Livers (DHOPEPROLONG)
End-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) of human donor livers mitigates ischemia-reperfusion injury, resulting in a reduction of post-reperfusion syndrome, early allograft dysfunction and biliary…
- Trial name
- DHOPEPROLONG (NCT05680246)
- Testing
- DHOPE-PRO
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- University Medical Center Groningen
Organ Perfusion Determined by Using NIRS Post Transcatheter PDA Occlusion or Medical Closure of PDA
PDA Occlusion Using NIRS
Our study will be a prospective observational study of all patients in the Norton Children's Hospital NICU (Neonatal Intensive Care Unit) who undergo a transcatheter PDA occlusion or medical closure of PDA to compare the two…
- Trial name
- NCT06359522
- Testing
- NIRS monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Chronic Kidney Disease
Pulsed Perfusion for Marginal Kidneys
Trends in organ donor pool are characterized by an increasing age and a shift towards cerebrovascular diseases as primary causes of death.
- Trial name
- PREDICTION (NCT02055950)
- Testing
- Storage of kidney in refrigerated solution, Kidney perfused by pulsatile machine
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Sepsis, Emergency Care
Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients
Despite early treatment, the deterioration and mortality of sepsis patients remains high. A possible explanation could be persistent tissue hypoperfusion, or undetected in the early phase despite the normalization of…
- Conditions
- Sepsis, Emergency Care, Microcirculation
- Trial name
- HEMOCAP (NCT06910891)
- Testing
- measurement of the peripheral perfusion index and marbling assessment
- Where
- 6 sites in France
- Volunteers
- 556 people
- Sponsor
- University Hospital, Limoges
Cardio-Pulmonary Bypass
Impact of Pulsatile Cardio-Pulmonary Bypass (CPB) on Vital Organ Recovery
This research study is about the effect heart-lung bypass procedures have on the vital organs (brain, heart, lungs, and kidneys) during open-heart surgery in pediatric patients.
- Trial name
- NCT00862407
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Milton S. Hershey Medical Center
Disorder Related to Lung Transplantation, Brain Death
Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation
The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.
- Conditions
- Disorder Related to Lung Transplantation, Brain Death, Graft Failure, Primary Graft Dysfunction
- Trial name
- EVLP_MI (NCT01967953)
- Testing
- EVLP Group
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- Policlinico Hospital
Organ Preservation, Brain Reperfusion or Regain of Brain Function During Normothermic Regional Perfusion
Multimodal Neuromonitoring During Normothermic Regional Perfusion for Organ Donors Determined Dead by circuLatory Criteria Following Withdrawal of Life Sustaining Measures
The aim of this study is to demonstrate that cerebral blood flow and brain function do not resume after death declaration in organ donors who undergo normothermic regional perfusion to restore organ function following death…
- Trial name
- NONOFLOW (NCT07423936)
- Testing
- Neuromonitoring
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Liver Neoplasms, Neoplasm Metastasis
A Phase I Study of Isolated Hepatic Portal and Arterial Perfusion (IHP) With Escalating Dose Melphalan for Primary or Metastatic Unresectable Cancers of the Liver
Patients with unresectable primary or metastatic cancer confined to the liver will undergo a 1 hour hyperthermic isolated hepatic perfusion (IHP) via the portal vein and hepatic artery with escalating dose melphalan.
- Trial name
- NCT00001587
- Testing
- Isolated hepatic portal and arterial perfusion, Melphalan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Liver Transplantation
Continued Access Study to Evaluate Performance of the Organ Recovery Systems _LifePort® Liver Transporter System, a Machine Perfusion System, for Liver Transplant (PILOT™_CA)
To provide continued access for the LLT system to provide additional safety data in support of the PILOT pivotal efficacy and safety trial
- Trial name
- PILOT™_CA (NCT05574361)
- Testing
- Hypothermic Machine Perfusion
- Where
- 5 sites in United States
- Volunteers
- 385 people
- Sponsor
- Organ Recovery Systems, Inc.
Cardiac Complications, Cardiopulmonary Bypass
Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) for cardiac operations may be accompanied by different patterns of visceral underperfusion. This could result in clinical patterns of lactic acidosis but in the most severe cases there is the risk for…
- Trial name
- NCT00747331
- Testing
- Fenoldopam mesilate
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Policlinico S. Donato
Ischemia/Reperfusion Injury
Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury. Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against…
- Trial name
- NCT00526695
- Testing
- Sevoflurane (Preconditioning)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Intra-Abdominal Hypertension, Critical Illness
Intra-Abdominal Pressure Changes During Continuous Renal Replacement Therapy in Critically Ill Patients
This prospective observational study will evaluate changes in intra-abdominal pressure in critically ill adult patients receiving continuous renal replacement therapy in the intensive care unit.
- Conditions
- Intra-Abdominal Hypertension, Critical Illness, Continuous Renal Replacement Therapy
- Trial name
- NCT07823387
- Testing
- Intravesical Intra-abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital