Clinical trials: Organ Transplants
Liver Transplant; Complications, Liver Transplant Rejection
Mortality, Morbidity and Risk Factors of Liver Retransplantation
This study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. Bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a…
- Conditions
- Liver Transplant; Complications, Liver Transplant Rejection, Liver Transplant Failure, Liver Diseases
- Trial name
- NCT04789213
- Testing
- Liver Transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Memorial Bahçelievler Hospital
Covid19, Kidney Transplantation
Monitoring of COVID-19 Vaccine Response in Organ Transplant Patients
Vaccination against SARS CoV-2 appears to be the best strategy today to control the COVID-19 pandemic. The first published studies with Pfizer, Moderna and Astra-Zeneca vaccines show very good vaccine protection in the general…
- Trial name
- COVATRANS (NCT04828460)
- Where
- France
- Volunteers
- 3,500 people
- Sponsor
- University Hospital, Strasbourg, France
Educational Activities, Organ Transplants
Development of Discharge Education Video for Solid Organ Transplant Recipients
Audiovisual teaching aids can play a significant role for the retention of new material and help overcome barriers such as the physical presence or time restrictions of an instructor.
- Trial name
- NCT05189340
- Testing
- Educational Videos
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Organ Donation, Liver Transplantation
EPI-STORM: Cytokine Storm in Organ Donors
Kidney and liver transplantation are the treatment of choice and are often the last therapeutic option offered to patients with chronic renal and liver failure.
- Conditions
- Organ Donation, Liver Transplantation, Kidney Transplantation, Graft Dysfunction
- Trial name
- EPI-STORM (NCT03786991)
- Testing
- No intervention
- Where
- 4 sites in Canada
- Volunteers
- 105 people
- Sponsor
- Université de Sherbrooke
Hepatitis B, Cirrhosis
Phase III, Study to Evaluate the Efficacy of Two Different HBV Vaccination Schemes in Patients With Hepatic Cirrhosis
The objective of this clinical trial is to compare the response rate obtained with two different vaccination schemes against HBV in cirrhotic patients.
- Conditions
- Hepatitis B, Cirrhosis, Awaiting Organ Transplant
- Trial name
- NCT01884415
- Testing
- HBV vaccine
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Organ Donation
Understanding Decision Making in the Intensive Care Unit: a National Study
Given how central Substitute Decision Makers (SDMs) are to the process leading to end of life decisions and sometimes, organ donation, it is striking how poorly understood this decision-making process is.
- Trial name
- NCT03850847
- Testing
- Step 1: Semi-structured Interviews, Step 2: National Telephone Survey
- Where
- 9 sites in Canada
- Volunteers
- 292 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Organ Transplant, Cancer
ORCHARD- Optimising Home Assessment of Rural Patients
This project assesses feasibility of providing medically vulnerable rural patients with Medical-Self-Assessment-Boxes containing equipment to use at home during telephone and video consultations (telemedicine) with GPs and other…
- Conditions
- Organ Transplant, Cancer, Inborn Errors of Metabolism, Immunosuppression
- Trial name
- ORCHARD (NCT05732922)
- Testing
- A sphygmanometer, a digital thermometer, a pulse oximeter and a peak flow meter will be given to participants to use during their telemedicine consultations with health care providers.
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Aberdeen
Transplant Patients
Development, Pilot Testing and Evaluation of the Effectiveness of Immunosuppressive Medication Adherence Care Bundle in Patients Undergoing Solid Organ Transplantation
Organ transplantation is the gold standard treatment method that increases the quality and duration of life in patients with end-stage organ failure, and one of the most important complications after transplantation is graft…
- Trial name
- NCT07447388
- Testing
- Identification of the Problem and Development of the Care Bundle
- Volunteers
- 100 people
- Sponsor
- Hacettepe University
Kidney Transplantation
A Safety and Efficacy Study of FCR001 Cell Therapy in Previously Transplanted Living Donor Kidney Recipients
An open-label study to assess the safety, tolerability, and efficacy of FCR001 cell therapy in adult recipients 3-12 months after kidney transplantation from a living donor.
- Trial name
- FREEDOM-2 (NCT01649388)
- Testing
- FCR001
- Where
- 3 sites in United States
- Sponsor
- Talaris Therapeutics Inc.
Organ Transplant
DCD IIT: Evaluating the Safety of Utilizing Donor Hearts From Donation After Circulatory Death (DCD) Donors
The purpose the research is to evaluate whether patients who receive a Donation after Circulatory Death (DCD) heart for cardiac transplantation using either normothermic regional perfusion (NRP) or direct procurement and…
- Trial name
- NCT05462041
- Testing
- DBD Donor Heart Transplantation, DCD Donor Heart Transplantation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Solid Organ Transplant
Feeding the Flame, One Day at a Time: Design and Acceptability of a Serious Game to Support Medication Adherence and Education for Pediatric Solid Organ Transplant Patients
Children and teenagers who receive a solid organ transplant (such as a kidney, liver, or heart) must take medications every day to keep their new organ healthy.
- Trial name
- Mystic Wizard (NCT07609303)
- Testing
- Mystic Wizard
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Hepatitis E
Seroprevalence of Hepatitis E in People With an Organ Transplant
Background: The hepatitis E virus causes an acute hepatitis that usually goes away by itself. Researchers in France studied people who received a liver or kidney transplant.
- Trial name
- NCT02190253
- Where
- 3 sites in United States
- Volunteers
- 447 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Organ Donation
Investigating Affective Attitude Question-behaviour Effects on Intention to Become an Organ Donor
The investigators aim to experimentally manipulate presence of questions on positive or negative affective attitudes to see if including these moderate as intention to become an organ donor.
- Trial name
- NCT02825862
- Testing
- Question-behaviour effect (for affective attitudes), Question-behaviour effect (negatively-worded attitudes)
- Where
- 4 sites in India, Ireland and 2 more
- Volunteers
- 999 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Solid Organ Transplantation, Artificial Intelligence
Assessment of Knowledge and Perceptions of Artificial Intelligence in Solid Organ Transplantation
The increasing abundance of clinical, genetic, radiological, and metabolic data in transplantation has led to a growing interest in applying artificial intelligence (AI) tools to optimize immunosuppression and overall patient…
- Trial name
- TransplantIA (NCT05932030)
- Testing
- Survey
- Volunteers
- 6,750 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Covid19
Efficacy, Safety, and Immunogenicity of Vaccine Reimmunization With a Third Homologous Versus Heterologous Dose Against COVID-19 in Patients Undergoing Solid Organ Transplantation.
Patients undergoing solid organ transplantation randomly selected from those who have received two doses of Spikevax (Moderna) vaccine, provided that a minimum of 8 weeks have elapsed from the second dose to the time of the start…
- Trial name
- REIN-TX (NCT05048940)
- Testing
- Janssen vaccine, Spikevax (Moderna) vaccine
- Where
- Spain
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Brain Death
Thyroxine Replacement in Organ Donors
To compare oral versus intravenous administration of thyroid hormone: 1) for reversibility of hemodynamic instability in organ donors, and, 2) the pharmacokinetics of oral vs iv thyroid administration
- Trial name
- NCT00238030
- Testing
- L-thryoxine, iv thryoxine
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cytomegalovirus Infections, Solid Organ Transplantation
Casting Light on HOst-cytomegaloviRUs Interaction in Solid Organ Transplantation
CMV disease remains the most frequent infectious complication post-transplant and it is associated to high morbidity and even mortality.
- Trial name
- HORUS (NCT05701228)
- Where
- 7 sites in France
- Volunteers
- 552 people
- Sponsor
- University Hospital, Bordeaux
CMV Retinitis
Evaluation of Safety and Efficacy of Autologous LB-DTK-CMV in Patients With Antiviral-Resistant and Refractory Cytomegalovirus Retinitis.
The goal of this exploratory clinical study is to evaluate the safety and efficacy of Cytomegalovirus-Specific T cells (LB-DTK-CMV) to treat patients diagnosed with antiviral-resistant and refractory cytomegalovirus retinitis.
- Trial name
- NCT07679412
- Testing
- LB-DTK-CMV
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- LucasBio
Solid Organ Transplant Recipient (Liver, Kidney, Heart), Rheumatologic Disorder
Immunogenicity of Fluzone High Dose in Immunocompromised Children and Young Adults
The purpose of this study is to determine whether Fluzone High Dose increases the immune response to the influenza antigens contained in the vaccine compared to standard-dose Fluzone in immunocompromised children and young…
- Conditions
- Solid Organ Transplant Recipient (Liver, Kidney, Heart), Rheumatologic Disorder, Human Immunodeficiency Virus (HIV), Bone Marrow Transplant (BMT)
- Trial name
- NCT01685372
- Testing
- Fluzone High Dose, Fluzone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver