Clinical trials: Organ Transplants
Renal Transplantation
Efficacy and Safety of FTY720 Versus Mycophenolate Mofetil (MMF, Roche Brand) in de Novo Adult Renal Transplant Recipients
This study will evaluate the safety and efficacy of FTY720 versus mycophenolate mofetil (MMF, Roche brand) combined with cyclosporine and corticosteroids in patients receiving a kidney transplant.
- Trial name
- NCT00239863
- Testing
- FTY720
- Volunteers
- 684 people
- Sponsor
- Novartis Pharmaceuticals
Infection in Solid Organ Transplant Recipients
Natural History of Cytomegalovirus (CMV) Infection and Disease Among Renal Transplant Recipients
Although the accumulated knowledge regarding Cytomegalovirus (CMV) infection increased substantially over the past years, several issues still deserve further investigation.
- Trial name
- NCT01833416
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Helio Tedesco Silva Junior
Transplant
Safety and Immunogenicity of Human Papillomavirus (HPV) Vaccine in Solid Organ Transplant Recipients
Human papillomavirus (HPV) affects a significant number of transplant patients. In women, human papillomavirus (HPV) causes genital warts, pre-cancerous areas of the cervix, and cervical cancer.
- Trial name
- NCT00677677
- Testing
- Human papillomavirus quadrivalent vaccine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Organ Donation
RCT- Comparing Testimonial Versus Documentary Organ Donation Video Education
Investigators will evaluate organ donation educational videos with a 2x3 single blinded Randomized Control Trial (RCT) in partnership with our 26 Latino Owned Barbershops (LOBs).
- Trial name
- NCT02836301
- Testing
- Control ending - Uplifting, Negative Consequences Ending, Unresolved Ending
- Where
- United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Skin Cancer, Infection Reactivation
Viral Reactivation and Skin Cancer
Several studies show that the incidence of skin cancer parallels the length and depth of immunosuppression. This study will analyze the correlation of viral reactivation and skin cancer in organ transplant recipients.
- Trial name
- NCT02395562
- Where
- Switzerland
- Volunteers
- 1,200 people
- Sponsor
- University of Zurich
Graft vs Host Disease, Complications of Organ Transplant Stem Cells
CEC Count Changes to Support GvHD Diagnosis.
In consideration of the fact that the vascular endothelium has been shown to be a target of GvHD in early stage and that the count of CEC may represent a marker of endothelial damage, we want to evaluate the changes in CEC counts…
- Conditions
- Graft vs Host Disease, Complications of Organ Transplant Stem Cells, Endothelial Dysfunction
- Trial name
- ALLOCEC (NCT02064972)
- Testing
- Patients undergoing allo-HSCT, who manifest GvHD.
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Chronic Disease, Immunocompromised
Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients
AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting.
- Conditions
- Chronic Disease, Immunocompromised, HIV Infection, Chronic Kidney Disease
- Trial name
- AMBU-VAX (NCT07391046)
- Testing
- Hospital-Based Vaccination Pathway
- Volunteers
- 1,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Renal Transplantation
Efficacy and Safety of FTY720 in de Novo Adult Renal Transplant Recipients
This study will evaluate the safety and efficacy of FTY720 combined with cyclosporine and corticosteroids in patients receiving a kidney organ transplant
- Trial name
- NCT00239785
- Testing
- FTY720
- Volunteers
- 684 people
- Sponsor
- Novartis Pharmaceuticals
Pediatric Solid Organ Transplant
Continuous Hemoglobin Monitoring in Pediatric Transplant
The purpose of this study is to determine the clinical utility of non-invasive monitoring of Hemoglobin (Hgb) and Plethysmograph Variability Index (PVI) values during the intraoperative period of visceral solid organ…
- Trial name
- NCT00958984
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Nebraska
Tissue and Organ Procurement, Health Behavior
Community Trial to Enhance Organ Donation
The purpose of this study is to determine the effect of a 5-minute video intervention regarding organ donation and transplantation on increasing the number of organ donor cards signed in Northeastern Ohio Bureau of Motor Vehicles…
- Trial name
- NCT00870506
- Testing
- video
- Where
- United States
- Volunteers
- 973 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Chronic Kidney Disease, Autoimmune Diseases
Capillary Sampling in Clinical Populations Undergoing Monitoring
Many people with long-term health conditions require regular blood tests to monitor their disease or medications. These blood tests are usually performed by taking blood from a vein during a hospital or clinic appointment.
- Conditions
- Chronic Kidney Disease, Autoimmune Diseases, Solid Organ Transplant Recipients
- Trial name
- CAPSICUM (NCT07802665)
- Testing
- Blood sampling with capillary sampling device(s)
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Bed-ridden Patient, Solid Organ Transplant
Use of an Off-the-Shelf Exergame as an In-Bed Gamified Rehabilitation Intervention for Severely Deconditioned Inpatients: A Feasibility Study
1. Study Title: Use of an Off-the-Shelf Exergame as an In-Bed Gamified Rehabilitation Intervention for Severely Deconditioned Inpatients: A Feasibility Study 2.
- Conditions
- Bed-ridden Patient, Solid Organ Transplant, Post Critical Care
- Trial name
- NCT06937463
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Asan Medical Center
End-stage Renal Failure, Kidney Graft Rejection
Reference Group Trial for The ONE Study
To investigate the progression of the immunological response in living-donor kidney transplant recipients treated with a standard immunosuppressive regimen.
- Trial name
- NCT01656135
- Testing
- Blood drawing for immune monitoring and questionnaires
- Where
- 8 sites in United States, France and 3 more
- Volunteers
- 70 people
- Sponsor
- University of Regensburg
Organ Transplant Recipients
Complement-activating Anti-human Leucocyte Antigen Donor Specific Antibodies in Solid Organ Transplantation
This project will involve a systematic literature review and meta-analysis of studies assessing the impact of complement-activating anti-Human Leukocyte Antigen (HLA) donor specific antibodies (DSA) on the allograft survival rate…
- Trial name
- NCT03438058
- Testing
- Graft survival and/or Rejection appearance
- Volunteers
- 7,547 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Transplantation, Ascorbic Acid Deficiency
Observational Study on the Variation of Ascorbic Acid in Patients Undergoing Solid Organ Transplantation
The objective of this observational clinical study is to evaluate the variations in ascorbic acid during the transplantation phases and how these variations influence the oxidative status and patient outcome.
- Trial name
- REDOX-TX (NCT06395259)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital
Complication of Transplanted Organ, Nos
Glucose/Insulin Clamp on Solid Organ Transplant (Liver, Kidney, Pancreas and Heart) on Cadaveric Donors
Our objective in this study will be to determine if implementing the glucose/insulin clamp (GICT) on cadaveric organ donors can: Prevent hyperglycaemia Drop in the inflammatory cytokine response after brain death after a minimum…
- Trial name
- NCT01304290
- Testing
- Hyperinsulinemic/normoglycemic clamp
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Cytomegalovirus Viraemia
Cell Mediated Immunity for Secondary Prophylaxis in CMV SOT Patients
This study will evaluate whether a test for Cytomegalovirus (CMV) specific cell-mediated immunity can be used to determine whether patients who complete a course of therapy for CMV viremia need secondary antiviral prophylaxis.
- Trial name
- Q-CMV (NCT02370758)
- Testing
- Valganciclovir or Ganciclovir
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
Respiratory Tract Viral Infections, Human Metapneumovirus (hMPV) Infection
Study of ALVR106 in Patients With Respiratory Viral Infections After Hematopoietic Cell and Solid Organ Transplant
A study to evaluate ALVR106; an allogeneic, off-the-shelf multi-virus specific T cell therapy that targets four community acquired respiratory viruses: respiratory syncytial virus (RSV), influenza, human metapneumovirus (hMPV)…
- Conditions
- Respiratory Tract Viral Infections, Human Metapneumovirus (hMPV) Infection, Parainfluenza (PIV) Infection, Respiratory Syncytial Viral (RSV) Infection
- Trial name
- NCT04933968
- Testing
- ALVR106
- Where
- 21 sites in United States
- Volunteers
- 17 people
- Sponsor
- AlloVir
Kidney Failure, Liver Failure, Chronic
Custodiol-N Solution Compared With Custodiol Solution in Organ Transplantation (Kidney, Liver and Pancreas)
Synopsis Title of Study A prospective, randomized, single blind multicentre phase III study on organ preservation with Custodiol-N compared with Custodiol solution in organ transplantation (kidney, liver and pancreas) Protocol…
- Conditions
- Kidney Failure, Liver Failure, Chronic, Kidney-Pancreas Failure
- Trial name
- NCT03627013
- Testing
- Custodiol-N Solution, Custodiol HTK Solution
- Where
- 4 sites in Austria
- Volunteers
- 362 people
- Sponsor
- Dr. F. Köhler Chemie GmbH
Organ Transplantation
Antibody Production Following H1N1 Influenza Vaccination in Organ Transplant Patients
Organ transplant patients and staff members at the Transplant Institute have received pandemic H1N1 influenza vaccine (Pandemrix) and specific antibody production was measured by haemagglutination inhibition according to the…
- Trial name
- NCT01254955
- Testing
- H1N1 vaccine Pandemrix
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital