Clinical trials: Organoids
Gastrointestinal Tumors，3D Organoids，Drug Sensitivity
Research on the Correlation Between Organoid Drug Sensitivity Testing and Precise Treatment of Gastrointestinal Tumors
Study the correlation between in vitro drug sensitivity screening of digestive tract tumor organoids and their clinical efficacy in anti-tumor treatment, evaluate the use of digestive tract tumor organoid drug sensitivity to…
- Trial name
- NCT06332716
- Testing
- Based on diagnostic and treatment guidelines/expert consensus, as well as clinical treatment experience, it is recommended that no more than 9 drugs be used for drug sensitivity testing each time.
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Jianjun Yang,MD
Pancreas Cancer
Development of a Prediction Platform for Neoadjuvant Treatment and Prognosis in Pancreatic Cancer Using Organoid
The investigators create organoid from the pancreatic cancer tissue obtained via EUS-FNA and EUS-FNB within the pancreatic cancer diagnostic process.
- Trial name
- NCT04777604
- Testing
- Organoid
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Samsung Medical Center
Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type
Intestinal Organoids
Over the last decade, the use of mini-organ or organoids has been increasingly developed in fundamental research. Indeed, digestive organoids represent an essential advance compared to classical culture systems (epithelial cell…
- Conditions
- Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type, Crohn Disease
- Trial name
- BIOÏDES (NCT05294107)
- Testing
- additional biopsies
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Rennes University Hospital
Endometrial Cancer
Generation of Endometrial Carcinoma Organoids
A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice.
- Trial name
- organoids endo (NCT07258186)
- Testing
- Generation of organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Regina Elena Cancer Institute
Staphylococcal Infections
Modeling Host-Pathogen Interaction Using Lymphoid Organoids
Background: Staphylococcus aureus (S.aureus) are bacteria that can make people sick. Sometimes, an S. aureus infection can develop inside the spine; these infections can lead to paralysis and death. Researchers do not know how S.
- Trial name
- NCT06479837
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Glioblastoma
Feasibility of ORGAnoids in Routine Clinical Practice for Molecular Analysis of the GLIOvascular Niche in Patients With Primary Brain Tumors.
The main goal of ORGA-GLIO trial is to establish the feasibility in routine clinical practice of ex-vivo organoid cultures composed of tumor cells within their microenvironment (glioblastoma organoid - GBO) and intra- and…
- Trial name
- ORGA-GLIO (NCT07029100)
- Testing
- Ex-vivo organoid culture
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Advanced Biliary Tract Cancer(BTC)
A Phase II Trial of Organoid Drug Sensitivity Testing to Guide Therapy in Unresectable Biliary Tract Cancers
This is a prospective, non-randomized, open-label, single-center phase II clinical trial. It aims to evaluate the efficacy and feasibility of using patient-derived tumor organoid drug sensitivity testing (ODST) to guide…
- Trial name
- NCT07351591
- Testing
- Organoid Drug Sensitivity Testing-Guided Therapy
- Volunteers
- 88 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Head and Neck Squamous Cell Carcinoma, Patient Derived Organoid
PDO Based Drug Sensitive Test in R/M HNSCC
To evaluate the consistency of drug efficacy between the clinical systemic treatment and drug sensitive test based on patient-derived organoid in R/M HNSCC patients, using a prospective and multicenter observational study to…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Patient Derived Organoid, Drug Sensitive Test in Vitro
- Trial name
- NCT06686342
- Testing
- No intervention, No Intervention: Observational Cohort
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Huashan Hospital
Pancreatic Ductal Carcinoma, Advanced Cancer
Using Tumor Models to Determine Treatments
The purpose of this study is to see if using Patient Derived Organoids (PDO) to choose a drug for the treatment of pancreatic cancer individually for each patient is useful.
- Conditions
- Pancreatic Ductal Carcinoma, Advanced Cancer, Epithelial Tumor
- Trial name
- NCT06813079
- Testing
- Cobimetinib, Ponatinib, Brigatinib
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Organoids, Epithelial Ovarian Cancer
Translational Analysis In Longitudinal Series of Ovarian Cancer ORganoids
This is a longitudinal observational phase II, single center, single arm study on the reliability of high grade serous ovarian carcinoma organoids obtained from primary debulking surgery (PDS)+adjuvant chemotherapy and…
- Trial name
- TAILOR (NCT04555473)
- Testing
- Tumor biopsy
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Radiation Enteritis, Inflammatory Bowel Diseases
Preclinical Evaluation of Multimodal Therapeutic Strategies in Intestinal Irradiation and Inflammatory Bowel Disease From Organoids
This study is carried out in patients with IBD and healthy subjects requiring ileocolonoscopy as part of routine care (disease monitoring or polyp/colon cancer screening).
- Trial name
- INTRUST (NCT05425901)
- Testing
- biopsy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cholangiocarcinoma, Hepatocellular Carcinoma
In Vitro Models of Liver and Pancreatic Cancer
The primary objective is to develop an in vitro model of cancer for laboratory study using liver, biliary and pancreatic cancer tissue.
- Conditions
- Cholangiocarcinoma, Hepatocellular Carcinoma, Pancreatic Neoplasm
- Trial name
- NCT02436564
- Testing
- Organoid in vitro culture
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Breast Neoplasms
Clinical Exploratory Study on Predicting Drug Sensitivity for Breast Cancer Treatment Using Simulated Organoid Models.
In this trial, we plan to construct a patient-derived organoid (PDO) model using fresh tumor tissue samples. Taking the relevant data of drug efficacy of breast cancer organoids as an example, it is shown that organoids may…
- Trial name
- NCT06702800
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xiangya Hospital of Central South University
Breast Cancer, Locally Advanced Breast Cancer (LABC)
Patient-Derived Organoids to Functionally Characterize Chemotherapy Resistance in Breast Cancer
This prospective observational study aims to functionally characterize chemotherapy resistance in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy.
- Trial name
- BC-PDO (NCT07516626)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Atlas University
Pancreatic Cancer Resectable
Development of a Prediction Platform for Adjuvant Treatment and Prognosis in Resected Pancreatic Cancer Using Organoid
The investigators create organoid from the pancreatic cancer tissue obtained via EUS-FNA and EUS-FNB within the pancreatic cancer diagnostic process.
- Trial name
- NCT04736043
- Testing
- Organoid
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Samsung Medical Center
T3c Diabetes
The Use of Islet Organoids in the Treatment of Pancreatic Surgery-related Diabetes
The purpose of this clinical trial is to verify the safety and effectiveness of autologous islet organoids transplantation after in vitro expansion for the treatment of pancreatogenic diabetes.
- Trial name
- NCT06415643
- Testing
- Islet organoids transplantation
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Zhejiang University
Gastric Cancer, Colon Cancer
Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer
Patients with gastric or colon cancer with peritoneal carcinomatosis will receive a biopsy of the tumor during their primary curative surgery.
- Conditions
- Gastric Cancer, Colon Cancer, Peritoneal Carcinomatosis
- Trial name
- Hi-STEP1 (NCT05652348)
- Testing
- Establishment of organoid cultures and in vitro sensitivity testing
- Where
- 5 sites in Germany
- Volunteers
- 48 people
- Sponsor
- Technische Universität Dresden
Glioblastoma, Organoid
Drug Response Testing and Repurposing Using Glioblastoma Organoid
The aim of this observational study, based on a prospectively collected cohort, is to evaluate the prognostic value of patient-derived organoids in predicting responses to conventional and repurposing drugs, including…
- Trial name
- NCT06782984
- Testing
- Organoid-based drug sensitivity test
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Chungnam National University Hospital
Advanced Gastric Carcinoma
The Clinical Efficacy of Drug Sensitive Neoadjuvant Chemotherapy Based on Organoid Versus Traditional Neoadjuvant Chemotherapy in Advanced Gastric Cancer
Neoadjuvant chemotherapy has become the mainstream recommended treatment for advanced gastric cancer. However, due to the heterogeneity of gastric cancer, part of some patients fail to benefit from the treatment.
- Trial name
- NCT05351398
- Testing
- PDO group, Traditional group
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Hematologic Malignancy
Novel 3D Hematological Malignancy Organoid to Study Disease Biology and Chemosensitivity
The objective of this project is to compare chemosensitivity between chemotherapy combinations in bone marrow aspirates using 3D organoid models.
- Trial name
- Organoid (NCT03890614)
- Testing
- Ancillary-Correlative - Creation of three-dimensional myeloma organoids using marrow aspirates
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Wake Forest University Health Sciences