Clinical trials: Orthopaedic
Bone Tumours, Bone Infection
Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection
Translational research aimed at improving diagnostic accuracy of musculoskeletal infection and musculoskeletal tumours using machine learning applied to clinical data, histopathological sections and genomic sequencing.
- Conditions
- Bone Tumours, Bone Infection, Prosthetic Joint Infection, Prosthetic Infection
- Trial name
- AIortho (NCT04746001)
- Testing
- Genomic sequencing, Histological examination
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Achilles Tendon Rupture
Achilles Tendon Rupture Patient Outcomes at 12 Months
Achilles tendon rupture is a common injury that can significantly impact strength, function, and quality of life. While non-surgical management using structured rehabilitation protocols such as the Swansea Morriston Achilles…
- Trial name
- ATR-12 (NCT07391553)
- Testing
- Non-Surgical Management Using the SMART Protocol
- Where
- 2 sites in United Kingdom
- Volunteers
- 115 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Fracture Forearm, Pediatric ALL
Taking POSNA's OrthoKids to the People
The objective of this project is to determine the efficacy of a tablet-based educational intervention at improving orthopaedic health literacy amongst families of pediatric patients treated for fractures in an outpatient setting.
- Trial name
- NCT04996745
- Testing
- Tablet-based educational intervention
- Where
- United States
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Pain
Preemptive Genotyping and Pain Management
The purpose of this study is to see if testing for genes related to pain and pain management before surgery affects how patients are treated for pain after surgery.
- Trial name
- NCT01813695
- Testing
- Preemptive genotyping in medical record, Genotyping not included in electronic medical record
- Where
- United States
- Volunteers
- 576 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pain
A Study of YZJ-4729 Tartrate Injection for the Treatment of Pain After Orthopedic Surgery
The primary objective is to evaluate the analgesic efficacy and safety of IV YZJ-4729 Tartrate Injection in patients with acute postoperative pain following Orthopedic surgery
- Trial name
- NCT06901830
- Testing
- YZJ-4729, Active Comparator: Morphine
- Where
- 21 sites in China
- Volunteers
- 150 people
- Sponsor
- Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
Chronic Heart Failure, Diabetes Mellitus
Exploring Acceptance and Outcomes of an Online-based Self-management Support System in Chronic Illness
The aim of the USECARE project is to improve and test SENACA, an ICT-based self-management support system for chronically ill patients and informal caregivers. 60 end-users will be instructed to use SENACA for approx.
- Conditions
- Chronic Heart Failure, Diabetes Mellitus, Chronic Obstructive Pulmonary Disease, Special Orthopaedic Co-Morbidity After Hip/Knee Replacement
- Trial name
- USECARE (NCT02832739)
- Testing
- SENACA - ICT based self-management support system
- Where
- 2 sites in Israel, Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Thrombosis, Deep Vein Thrombosis
Thromboprophylaxis in Patients Undergoing Orthopedic Surgeries; Using Propensity Score Matching
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common post-operative complication.
- Conditions
- Thrombosis, Deep Vein Thrombosis, Surgery--Complications
- Trial name
- NCT03483181
- Testing
- Xarelto (rivaroxaban), Lovenox (enoxaparin)
- Where
- Vietnam
- Sponsor
- Hanoi Medical University
Malocclusion, Angle Class II
Effects of Modified Fixed Twin Block Versus Removable Twin Block on Skeletal Class 2 Growing Patients With Mandibular Deficiency
Effects of modified fixed twin block versus removable twin block on skeletal class 2 growing patients with mandibular deficiency: A Randomized Clinical Trial
- Conditions
- Malocclusion, Angle Class II, Mandible Small
- Trial name
- NCT05993156
- Testing
- modified Fixed twinblock, removable twin block
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Depression, Old Age; Debility
Assessment of Depression Levels in Elderly Patients With an Orthopedic Fracture Compared to Patients After a Stroke.
Depression is common among elderly patients hospitalized due to acute conditions like strokes or osteoporotic fractures. It has significant impacts on quality of life, hospitalization rates, and mortality.
- Conditions
- Depression, Old Age; Debility, Stroke, Fractures, Bone
- Trial name
- NCT06570356
- Testing
- Geriatric Depression Scale - 15
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shmuel Harofeh Hospital, Geriatric Medical Center
Anterior Pelvic Ring Fractures
Comparison of Subcutaneous INFIX and EXFIX for Anterior Pelvic Ring Fractures Requiring Stabilization
The purpose of this research is to compare patient outcomes of two treatment methods that are currently used as standard of care to treat anterior pelvic ring injuries that require stabilization.
- Trial name
- NCT02403154
- Testing
- Internal Fixator, External fixator
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Elbow Fracture, Stiffness of Elbow, Not Elsewhere Classified
The Turkish Version of the Shanghai Elbow Dysfunction Score
The Shanghai Elbow Dysfunction Score (SHEDS) is originally developed in English to evaluate elbow function in patients with elbow stiffness.
- Conditions
- Elbow Fracture, Stiffness of Elbow, Not Elsewhere Classified, Orthopedic Disorder, Assessment, Self
- Trial name
- NCT04872205
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Istanbul University - Cerrahpasa
Telemedicine, Fracture
The Impact of Telemedicine on Orthopaedic Trauma Patients With Closed Fractures
The purpose of this study is to determine whether telemedicine video calls for follow-up visits between patients and their orthopaedic trauma surgeons has an impact on patient satisfaction, quality of life, and treatment…
- Trial name
- NCT01991782
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Hip Arthritis
Digital Sizing for Orthopaedic Hip Implants
Hip implants come in different sizes. Currently, surgeons predict the implant size that will be needed using an analogue method whereby photos of the implant sizes are overlaid on the x-rays.
- Trial name
- NCT00665210
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Rare Disorders, Sarcoma of Bone and Connective Tissue
Characterization of the Methylation Profile of Stored Human Samples
The project, funded by the PNRR under Mission 4 "Education and Research," aims to strengthen the network of Italian biobanks by improving data management in accordance with the FAIR principles (Findable, Accessible…
- Conditions
- Rare Disorders, Sarcoma of Bone and Connective Tissue, Inflammatory Articular Diseases
- Trial name
- DNAmetCRB (NCT07573072)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Istituto Ortopedico Rizzoli
Surgery, Orthopedic Disorder
Perioperative Factors Impacting Surgical Risk and Outcomes in Children
This prospective study will measure various factors in children coming in for ambulatory surgery and attempt to create a scoring system that would be able to predict post-operative outcomes.
- Trial name
- NCT03436667
- Testing
- Spirometry, Reaction Time
- Where
- United States
- Sponsor
- Nationwide Children's Hospital
Postoperative Cognitive Dysfunction, Orthopedic Procedures
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia.
- Conditions
- Postoperative Cognitive Dysfunction, Orthopedic Procedures, Postoperative Pain Management, Hip Fracture
- Trial name
- REMIND-ORTHO (NCT07113483)
- Testing
- Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO]
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Regional Anaesthesia
Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery
this study is designed to evaluate and compare the efficacy of dexmedetomidine and nalbuphine as adjuvants to 0.5% bupivacaine in ultrasound-guided infraclavicular brachial plexus block for patients undergoing elective upper limb…
- Trial name
- NCT07279727
- Testing
- Nalbuphine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
Typically Developing Children, Talipes Equino Varus
Measuring Normal and Impaired Walking in Children Using the GAITRite Walkway
Walking measurement in children is important but there are challenges associated with obtaining reliable repeatable data in a clinical setting that is meaningful and easy to interpret.
- Conditions
- Typically Developing Children, Talipes Equino Varus, Paediatric Orthopaedic, Paediatric Neurological
- Trial name
- NCT05571501
- Testing
- Gait assessment using the GAITRIte walkway
- Where
- United Kingdom
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Orthopedic Disorders
Remote Orthopedic Outpatient Consultation by Help of Telemedicine
Patients from 4 local communities in northern Norway referred (either new or follow up) to orthopaedic department, University hospital of Northern Norway for outpatient consultation, are randomly assigned to either remote…
- Trial name
- NCT00616837
- Testing
- Telemedicine consultation, Standard care in orthopaedic outpatient clinic
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- University Hospital of North Norway
Shoulder Instability
Automated AI Voice Calls for Postoperative Follow-up After Arthroscopic Shoulder Instability Surgery
This prospective, single-center randomized clinical trial evaluates the technical efficacy, accuracy, and operational performance of an automated conversational artificial intelligence (AI) voice agent for postoperative follow-up…
- Trial name
- FOLAI (NCT04972331)
- Testing
- SMS Pre-notification, No Pre-notification
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Institut de Chirurgie Reparatrice Locomoteur et Sports