Clinical trials: Orthopaedic Surgery
Delirium, Anxiety
Effect of Preoperative Anxiety on Postoperative Delirium in Elderly Patients Undergoing Orthopaedic Surgery.
Postoperative delirium is a common and important complication in patients. The aim of this study was to investigate whether preoperative anxiety predicted onset of postoperative delirium in elderly patients undergoing orthopaedic…
- Trial name
- NCT04216615
- Testing
- preoperative anxiety
- Volunteers
- 290 people
- Sponsor
- Xuzhou Medical University
Necrosis of Femoral Head, Knee Osteoarthritis
Ketamine Prevent POCD
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent.
- Trial name
- KPPOCD (NCT02220400)
- Testing
- Ketamine
- Where
- 3 sites in China
- Volunteers
- 484 people
- Sponsor
- RenJi Hospital
Postoperative Pain, Foot Numbness
Ultrasound Guidance Versus Electrical Stimulation for Continuous Popliteal-Sciatic Nerve Blocks
Research study to determine if pain relief following foot and/or ankle surgery is influenced by the technique used to place perineural catheter.
- Trial name
- NCT00876681
- Testing
- Popliteal catheter placed via ultrasound or electrical stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Urologic Diseases, Cardiovascular Diseases
Patient Empowerment for Major Surgery Preparation @ Home
Non-randomized monocentric open cohort study vs historical comparative group testing the efficacy of a multimodal prehabilitation program (based on physical activity, nutritional support and mental preparation) for unfit patients…
- Conditions
- Urologic Diseases, Cardiovascular Diseases, Thoracic Diseases, Orthopedic Disorder
- Trial name
- Paprika (NCT04190719)
- Testing
- multimodal prehabilitation
- Where
- France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Chronic Pain
Predisposition to Persistent Pain After Orthopaedic Surgery: Genetic Aspects
The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery.
- Trial name
- NCT01989351
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- ASST Gaetano Pini-CTO
Femoroacetabular Impingement Syndrome
Early Versus Delayed Weightbearing in Femoroacetabular Impingement Syndrome Patients
Femoroacetabular impingement syndrome (FAIS) is a condition caused by an abnormal bone structure that causes the bones on either side of the hip joint to impinge on each other during certain movements, thus causing pain.
- Trial name
- FASTHIP (NCT05256628)
- Testing
- Early Weightbearing, Protected Weightbearing
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Women's College Hospital
Spinal Anesthesia Duration
Comparative Analysis of Intraoperative Effect Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Spinal Anaesthesia in Lower Limb Orthopedic Surgeries to Evaluate the Hemodynamic Stability and Onset and Duration of Motor Block of Using Intrathecal Dexmedetomidine and Fentanyl
Spinal anesthesia is the most widely employed procedure for lower limb orthopedic operations, as it is very cost-effective and simple to apply.
- Trial name
- NCT07078201
- Testing
- Dexmedetomidine, fentanyl
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Nashwa Ahmed
Ehlers-Danlos Syndrome
Evaluation of a Cohort of Patients With Ehlers-Danlos Syndrome Treated With Orthopedic Surgery (SED-eval)
The aim of this study is to assess the joint involvement (shoulder - ankle - knee - elbow - wrist) in patients with Ehlers-Danlos Syndrome and treated by surgery.
- Trial name
- SED-eval (NCT05137379)
- Testing
- A joint functional score based on the affected joint
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Patients Who Are in Need of Short or Long Term Rehabilitation Due to Neurological Event (Mainly Stroke) or Post Orthopedic Surgery
Mind Body Therapy During Geriatric Rehabilitation
The main goal of geriatric rehabilitation following an acute illness is rapid restoration of normal activity. The key elements are pain control, restoration of bowel functions, good sleep quality, appetite and general well-being…
- Trial name
- NCT01074788
- Testing
- mind body therapy
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Post-spinal Hypotension, Orthopedic Surgery
Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery
This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg/kg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries…
- Conditions
- Post-spinal Hypotension, Orthopedic Surgery, Spinal Aneshtesia
- Trial name
- NCT06995690
- Testing
- Ketamine, Normal Saline
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Scoliosis
Pharmacokinetics of Aminocaproic Acid in Scoliosis Surgery
This study will evaluate the pharmacokinetics of antifibrinolytic drug epsilon-aminocaproic acid (EACA) in children undergoing Posterior spinal fusion surgery (PSF) at The Children's Hospital of Philadelphia (CHOP) who receive…
- Trial name
- NCT01408823
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
ACL Surgery, Pain Management
Efficacy of Methylprednisolone for Pain Control After ACL Repair
Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder.
- Trial name
- NCT07158476
- Testing
- Meloxicam 15 mg, Medrol 4 MG Oral Tablet Includes Medrol Dosepak, Gabapentin 300 mg
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- St. Louis University
Scoliosis
The Idiopathic Scoliosis and Its Treatment (Orthopaedic and Surgery): Effect of the Severity, the Orthosis and the Arthrodesis on the Gait
The purposes of this study were as follows: 1) to compare locomotion parameters (kinematic, EMG, mechanical work and energy cost changes during walking in able-bodied subjects and AIS patients,2) to evaluate the effects of the…
- Trial name
- scoliosis (NCT00842218)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Acute Post Operative Pain
Improvement in Postoperative Pain Outcomes
This is an observational study project aims at improving postoperative pain outcomes by evaluating the current status of postoperative pain managements in the institution.
- Trial name
- NCT05624502
- Where
- Saudi Arabia
- Volunteers
- 1,000 people
- Sponsor
- King Saud University
Regional Anesthesia Morbidity
Dexmedetomidine in IVRA
A prospective randomized controlled double-blinded study will be conducted on 90 patients assigned randomly into three equal groups,
- Trial name
- NCT05123170
- Testing
- Dexmedetomidine Injectable Solution [Dexdomitor], Lidocaine IV
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Hip or Knee Replacement
CBP-0276 to Reduce Opioid Use in Adults Undergoing Major Orthopedic Surgery
Randomized, double-blind, clinical study to evaluate the safety and efficacy of CBP-0276 at doses of 600 mg/day in reducing opioid use in pain management in adult patients undergoing major orthopedic surgery.
- Trial name
- CBP0276-Opd (NCT07687966)
- Testing
- CBP-0276
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Clarent Biopharma, Inc.
Stress, Psychological, Pain
Anticipated Versus Actual Patient and Caregiver Burden Following Ambulatory Orthopedic Surgery
In 2011, 38.6 million hospital stays occurred in the United States at a cost of $387.2 billion. 47.9 percent involved hospitalizations during which surgical procedures were performed.
- Trial name
- Work Burden (NCT02550886)
- Testing
- Survey
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Hospital for Special Surgery, New York
Rheumatoid Arthritis, Orthopedic Surgery
Local Analgesia in Knee- and Hipatroplastic Surgery in Patients With Rheumatic Disease: Extra- vs. Intracapsulare Position of Catheter
Postoperative pain is part of surgery trauma. In orthopedic surgery artroplastic replacement of knee- and hipjoints are common. Postoperative pain relieve can be complicated.
- Conditions
- Rheumatoid Arthritis, Orthopedic Surgery, Analgesia
- Trial name
- NCT01050738
- Testing
- Position of catheter
- Where
- Sweden
- Volunteers
- 72 people
- Sponsor
- Spenshult Hospital
Patient Blood Management
Impact of Patient Blood Management (PBM) at the Schulthess Clinic
Aim of this study is to analyze the transfusion requirements of allogenic blood products at the Schulthess Clinic for patients that had major orthopedic or major spine surgery between 2019 and 2024 order to identify patients at…
- Trial name
- PBM (NCT06363214)
- Testing
- Patient blood management
- Volunteers
- 16,000 people
- Sponsor
- Schulthess Klinik
Degenerative Arthritis of Left Glenohumeral Joint, Degenerative Arthritis of Right Glenohumeral Joint
Costs and Consequences of Three Common Orthopedic Procedures on the Upper Extremity
This study compares costs and effectiveness / utility of three common orthopedic surgeries in shoulder and hand from the perspective of the Swiss health system and the clinic.
- Conditions
- Degenerative Arthritis of Left Glenohumeral Joint, Degenerative Arthritis of Right Glenohumeral Joint, Rotator Cuff Tear Arthropathy, Rotator Cuff Tear
- Trial name
- NCT01954433
- Testing
- Operated TSA Patients, Operated RCR Patients, Resection interposition suspension arthroplasty (RISA)
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- Schulthess Klinik