Clinical trials: Orthopaedic Trauma
Wound of Knee, Wound of Hip
Study to Compare Negative Pressure Wound Therapy or Standard Dressings After Orthopedic Surgery
The aim of this study is to assess the prevention of incision healing complications in patients undergoing Total Knee Arthroscopy (TKA) and Total Hip Arthroscopy (THA) treated with either Single-Use Incisional NPWT (Negative…
- Trial name
- PICO (NCT02064270)
- Testing
- Single-Use Negative Pressure Wound Therapy, Standard postsurgical dressings
- Where
- United States
- Volunteers
- 526 people
- Sponsor
- University of Missouri-Columbia
Hip Fracture
Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery?
Does tranexamic acid improve the perioperative care of those patients treated surgically for hip fracture by decreasing the proportion of patients requiring transfusion and decreasing total perioperative bleeding.
- Trial name
- NCT01714336
- Testing
- tranexamic acid
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Mayo Clinic
Ankle Fracture
Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)
This study is a randomized controlled trial assessing pain control in ankle fractures repaired with open reduction and internal fixation.
- Trial name
- NCT02480621
- Testing
- Liposomal Bupivacaine with Bupivacaine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Jamaica Hospital Medical Center
Delirium
Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period
Delirium (acute confusion) is a highly prevalent condition among hospitalized elders with substantial morbidity within the hospital and beyond.
- Trial name
- SHARP (NCT00586196)
- Testing
- donepezil
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hand Injuries, Wrist Injuries
Study of A Long Lasting Local Anesthestic for Hand, Wrist or Finger Surgery
The purpose of this study is to compare Exparel, a new, long-lasting numbing medication and a shorter-acting nerve block to a traditional single-shot nerve block in patients having hand, wrist or finger surgery.
- Conditions
- Hand Injuries, Wrist Injuries, Finger Injuries
- Trial name
- NCT02058303
- Testing
- Exparel Forearm block, Bupivacaine supraclavicular block
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD
Pain, Fracture, Sprain
Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain
Assess whether transbuccal fentanyl provides more rapid relief of orthopedic pain, than does the comparator Percocet
- Trial name
- FAIRTOP (NCT00685295)
- Testing
- Fentanyl, Lansoprazole, Oxycodone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Fractures, Bone, Deformity; Bone
Virtual Reality Distraction During Outpatient Pediatric Orthopedic Procedures
Virtual Reality(VR) has had promising applications in science and medicine, including intervention delivery. The use of VR interventions has been studied in a wide range of medical conditions, including anxiety, phobias, obesity…
- Trial name
- NCT05510232
- Testing
- A treatment group that will watch a non-VR video via an iPad, A treatment group that will have headset on and will watch a non-VR video, A treatment group that will be immersed in the VR game (Bear Blast) via the headset.
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Hospital for Special Surgery, New York
Orthopaedic Trauma Infections
BBOT: Bacterial Burden in Ortho Trauma Procedures
The purpose of this research project is to improve understanding of the potential role of highly sensitive bacterial tests in diagnosing infected non-healing fractures compared to the current standard of care, microbiologic…
- Trial name
- NCT03126448
- Testing
- Highly Sensitive Assays
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Surgical Site Infection
Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients
Intervention: This study will involve three different study arms with different interventions prior to surgery: (1) shower only, (2) shower plus Theraworx wipes, (3) shower plus chlorhexidine wipes Study Design: Single center RCT…
- Trial name
- NCT03401749
- Testing
- Chlorhexidine Gluconate 2% Wipe, Theraworx Bath Wipes
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- University of Alabama at Birmingham
Bone Sarcoma, Femur Fracture
Dalteparin in Preventing DVT in Participants With Cancer
This trial studies how well dalteparin works in preventing deep vein thrombosis (DVT) (blood clots) in participants with cancer. Dalteparin is a blood thinner that can treat blood clots and may prevent them from forming.
- Conditions
- Bone Sarcoma, Femur Fracture, Lymphoma, Metastatic Neoplasm
- Trial name
- NCT00525057
- Testing
- Dalteparin
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- M.D. Anderson Cancer Center
Surgical Site Infection, Vancomycin
Pharmacokinetics of Preoperative Vancomycin
A study of plasma and tissue vancomycin pharmacokinetics in pediatric surgical patients.
- Trial name
- NCT03453684
- Testing
- Administration of Vancomycin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Incision, Surgical
Orthopaedic Surgical Wound Closure Comparison Study
This study is trying to find out if there is one method of surgical incision closure is better than another. The three different wound closure methods in this study are currently used in standard of care.
- Trial name
- NCT05251064
- Testing
- Suture, Clozex, Zipline
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Virginia
Bacterial Infection
Study to Assess Safety and Clinical Activity of Local MBN-101 in Treatment of Infected Bone Sites
This study evaluates the safety and clinical benefit of MBN-101 administered intraoperatively to osteosynthesis or osteomyelitis sites for patients diagnosed with an orthopedic infection, with or without orthopaedic hardware.
- Trial name
- NCT02436876
- Testing
- MBN-101
- Where
- 6 sites in United States
- Volunteers
- 29 people
- Sponsor
- Microbion Corporation
Patient Satisfaction, Sports Injury
Virtual Phone Visits Compared to In-Person Physical Visits for Post-Operative Follow-Up at a Sports Medicine Clinic
This study will compare patient reported outcomes (PROs) of patients seen at virtual phone visits compared to in-person visits for 6 weeks, 12 weeks, and 6 months post-operative follow up at a sports medicine clinic.
- Conditions
- Patient Satisfaction, Sports Injury, Surgery, Orthopedic Disorder
- Trial name
- NCT05998148
- Testing
- virtual phone appointment visits
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Jonathan Wu
Orthopedic Surgery, Opioid Use
Post-op Crowd Sourcing Health Data Via Text-messaging
The Center for Disease Control has labeled the opioid prescription drug crisis an "epidemic" in the United States and recently this epidemic has been named a public health emergency.
- Conditions
- Orthopedic Surgery, Opioid Use, Acute Injuries Knee, Neurosurgery
- Trial name
- NCT03532256
- Testing
- Observation, Text to online survey, Bi-directional text script
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- University of Pennsylvania
Diabetes, Morbid Obesity
Closed Incision Negative Pressure Wound Therapy vs. Foam as Post Operative Dressing
The primary objective is to assess the frequency of a wound healing complication, in a closed incisional wound in a "high risk" surgical incision when treated with Negative Pressure Wound Therapy versus a highly absorbent…
- Conditions
- Diabetes, Morbid Obesity, Lymphedema, Orthopedic Disorder
- Trial name
- NCT05427916
- Testing
- Avance Solo, Optifoam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pertrochanteric Fracture
Effects of a Surgical Site Injection on Pain Scores and Narcotic Use After Orthopaedic Trauma Surgery
This is a phase I, randomized, single-blind, placebo-controlled, single-center study of the effects of surgical site injection on pain and narcotic utilization in participants who undergo surgery for lower extremity fractures.
- Trial name
- NCT03693404
- Testing
- Marcaine, Duramorph , ketorolac, Bupivacaine (Marcaine), General Anesthetics
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- NYU Langone Health
Injuries, Injury Arm
Virtual Reality for Pain in Acute Orthopedic Injuries
The goal of this study is to pilot test a skills-based virtual reality (VR) for acute orthopedic injury. It will measure the feasibility, signals of improvement, exploratory pain mechanisms, and user experience of an established…
- Conditions
- Injuries, Injury Arm, Injury;Sports, Injury, Knee
- Trial name
- NCT05552430
- Testing
- RelieveVRx
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Pain
Safety and Efficacy Study of Fentanyl Buccal Tablet Use in the Emergency Department for Isolated Extremity Injury
The primary purpose of this study is to evaluate fentanyl buccal tablet (FBT) for analgesia in comparison to standard analgesia, to determine if the FBT allows for faster achievement of "significant analgesia"
- Trial name
- FAIRTOP II (NCT01270659)
- Testing
- Fentanyl, Oxycodone/acetaminophen
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Oklahoma
Bone Fractures, Radius Fractures
Management of Distal Radius Fractures in Children Younger Than 11 Years Old.
This fractures have been managed with anatomical reduction performed under anesthesia or using sedatives. In our institution this means prolonged hospital stay, involvement of an anesthesiologist and the use of an special room in…
- Conditions
- Bone Fractures, Radius Fractures, Closed Fractures
- Trial name
- NCT02670629
- Testing
- Partial reduction with overriding position, Closed anatomic reduction
- Volunteers
- 58 people
- Sponsor
- Carlos A Acosta-Olivo