Clinical trials: Orthopedic Injury
Unstable Pelvic Ring Fracture, Unstable Acetabulum Fracture
Timing of Orthopaedic Surgery in the Multiply-injured Patient: Development of a Protocol for Early Appropriate Care
Early fixation of unstable fractures of the femur, pelvis, and acetabulum reduces some complication rates. However, in patients with multiple injuries, the optimal treatment of skeletal trauma may be affected by severe injury to…
- Conditions
- Unstable Pelvic Ring Fracture, Unstable Acetabulum Fracture, Femur Fracture
- Trial name
- NCT00888160
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- MetroHealth Medical Center
Hamstring Muscle Strain, Adult Acquired Flatfoot Deformity
Correlation Between Soft Tissue Displacement and Functional Performance in Orthopedic Patients
The goal of this clinical trial is to investigate the correlations between dynamic soft tissue displacement, mechanical properties, and functional recovery across three studies: biceps femoris long head (BFlh) muscle injury…
- Conditions
- Hamstring Muscle Strain, Adult Acquired Flatfoot Deformity, Ulnar Collateral Ligament Sprain After Reconstruction
- Trial name
- NCT07870408
- Testing
- Nordic Hamstring Exercise Training, Custom Foot Orthoses and Exercise Therapy, Forearm Blood Flow Restriction Training
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Patient Reported Outcome Measures, Recovery of Function
FIT Study (Functional Outcomes In Trauma Study)
Why? There is not much information in the UK on how well patients who sustain major trauma function afterwards. Major trauma is defined as significant injuries with a calculated 'injury severity score' (ISS) over 15.
- Conditions
- Patient Reported Outcome Measures, Recovery of Function, Rehabilitation, Disability Evaluation
- Trial name
- NCT04074382
- Testing
- Online Questionnaires, Qualitative Interviews
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Simulation Based Medical Education
Optimizing Simulation-Based Training in Orthopedics: Exploring Deliberate Flawed Performance for Dynamic Hip Screw Osteosynthesis
Proximal femoral fractures (PFF) are associated with increased mortality when surgical intervention is delayed, with evidence supporting osteosynthesis within 12 to 24 hours of admission to minimize risk.1, 2 Consequently…
- Trial name
- NCT06729372
- Testing
- Deliberate Flawed Performance, Error Avoidance Training
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.
Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Feasibility Study on Nitropaste Using Intraoperative SPY Imaging.
- Conditions
- Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar)
- Trial name
- SPY NITROPASTE (NCT07004764)
- Testing
- Nitroglycerin Ointment 2%
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Lower Extremity Injury
Improving Recovery After Orthopaedic Trauma: Cognitive-Behavioral Based Physical Therapy (CBPT)
The goal of the CBPT study is to determine the efficacy of the CBPT program for improving outcomes in service members and civilians at-risk for poor outcomes following traumatic lower-extremity injury.
- Trial name
- CBPT (NCT03335657)
- Testing
- CBPT, Education Treatment
- Where
- 8 sites in United States
- Volunteers
- 633 people
- Sponsor
- Major Extremity Trauma Research Consortium
Fall Injury, Hip Fractures
Fall, Fracture and Frailty
This project aims to improve the global outcome for an aging individual after a traumatic fall, through identifying conditions contributing to a fall and promoting recovery and rehabilitation.
- Conditions
- Fall Injury, Hip Fractures, Risk Reduction, Osteoporosis, Osteopenia
- Trial name
- FFF (NCT05712252)
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane
Surgical Wound, Orthopedic Disorder of Spine
Local Wound Anesthesia in Spine Surgery
Prospective, randomized, double-blinded, trial regarding the effect of local wound infiltration at the end of spine surgery; randomizing 1:1:1 between NaCl, Ropivacain, Levobupivacaine combined with Tramadol
- Trial name
- NCT05693454
- Testing
- Infiltration with NaCl, Infiltration with Ropivacain, Infiltration with a combination of Levobupivacaine and Tramadol
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Balgrist University Hospital
Rotator Cuff Tears, Postoperative Pain
The Effect of Liposomal Bupivacaine Nerve Block (Exparel) in Rotator Cuff Surgery
The goal of this clinical trial is to investigate if there is a difference in pain after an arthroscopic rotator cuff surgery when a nerve block is performed with liposomal bupivacaine versus the standard treatment of bupivacaine…
- Conditions
- Rotator Cuff Tears, Postoperative Pain, Opioid Use
- Trial name
- NCT06139666
- Testing
- Exparel Injectable Solution, Bupivacaine Injectable Solution
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- The Cooper Health System
Post Traumatic Chronic Pain
The Biopsychosocial Model to Identify Risk Factors for Chronic Postoperative Pain in Orthopedic Trauma Surgery Patients
This study aims to assess multidimensional risk factors for chronic post-traumatic pain in orthopedic trauma surgery patients. The purpose is to better understand pain chronification mechanisms by quantifying the interaction…
- Trial name
- TRAUMA PAIN (NCT07685184)
- Testing
- • biological collection
- Volunteers
- 600 people
- Sponsor
- University Hospital, Montpellier
Pertrochanteric Fracture
Effects of a Surgical Site Injection on Pain Scores and Narcotic Use After Orthopaedic Trauma Surgery
This is a phase I, randomized, single-blind, placebo-controlled, single-center study of the effects of surgical site injection on pain and narcotic utilization in participants who undergo surgery for lower extremity fractures.
- Trial name
- NCT03693404
- Testing
- Marcaine, Duramorph , ketorolac, Bupivacaine (Marcaine), General Anesthetics
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- NYU Langone Health
Haemodynamic Instability
Internal Jugular Vein and Spinal-induced Hypotension
The study aims to assess internal jugular vein ultrasound derived measurements and indices prior to spinal anesthesia in elderly population who fulfills predetermined inclusion criteria and might greatly benefit from an…
- Trial name
- NCT05015218
- Testing
- Vacular Ultrasound
- Where
- 2 sites in Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Distal Radius Fracture, Distal Radius Fracture Fixation
Evaluating the Effectiveness of Remote Monitoring for Post-Operative Management of Distal Radius Fractures
This randomized controlled trial evaluates whether remote monitoring can provide a safe and effective alternative to traditional in-person follow-up after surgical fixation of distal radius fractures.
- Trial name
- NCT07219979
- Testing
- Remote Monitoring Follow-Up, Standard In-Person Follow-Up
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Missouri-Columbia
Ankle Fractures, Proximal Humeral Fracture
Orthopaedic Conservative Treatment in the Time of Covid-19 Pandemic
This is a one centered retrospective study. Tendency for surgical interventions in the pre-pandemic period was reduced to protect surgical team and patients.
- Conditions
- Ankle Fractures, Proximal Humeral Fracture, Wrist Fracture
- Trial name
- NCT04623346
- Testing
- Observation for study group
- Where
- Turkey (Türkiye)
- Volunteers
- 262 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Regional Anesthesia, Music
MUSIC-CARE and Locoregional Anesthesia for Orthopedic Surgery
Anxiety, fright, stress and pain have always been sources of emotional distress for patients undergoing invasive procedures in clinical settings.
- Conditions
- Regional Anesthesia, Music, Forearm; Injury, Superficial, Multiple (With Elbow)
- Trial name
- NCT05015985
- Testing
- Music-Care, control group
- Where
- France
- Volunteers
- 80 people
- Sponsor
- American Hospital of Paris
Trauma, Infection
Use of 5-Aminolevulinic Acid to Assess Bone and Tissue Profusion in Orthopaedic Infection Patients
The focus of this study is to explore the variability distribution of 5-Aminolevulinic Acid (ALA)associated with bone and soft tissue perfusion in infection patients, using 5-ALA fluorescence imaging.
- Conditions
- Trauma, Infection, Bone Fracture
- Trial name
- NCT04976049
- Testing
- Imaging using 5-Aminolevulinic Acid (5-ALA) during surgery
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Anterior Cruciate Ligament Injury, Knee Injury
Comparison of Quadriceps and Semitendinosus Grafts in ACL Reconstruction Using Data From the Danish Knee Ligament Reconstruction Registry (DKRR)
This study looks at two different types of tendon (tissue) used in knee surgery to repair a torn anterior cruciate ligament (ACL), which is a common injury in active people.
- Conditions
- Anterior Cruciate Ligament Injury, Knee Injury, Ligament Reconstruction, Sports Injuries
- Trial name
- NCT06980285
- Where
- Denmark
- Volunteers
- 2,500 people
- Sponsor
- Abdirahman Hassan Omar
Orthopaedic Surgery
Development of a Drill Guidance System to Aid Intra-operative Surgical Drilling
The Investigators have developed a camera based drill guidance system to improve the accuracy of surgical drilling. The aim of the study is to assess: Accuracy in vivo Safety Acceptability of use amongst surgeons and theatre staff
- Trial name
- NCT06309784
- Testing
- Drill Guidance System (DGS)
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Femur Fracture, Periprosthetic Fracture of Hip
Dose-Response Association Between Cerclage Wire Number and Infection Risk
The purpose of this dual-center retrospective study is to investigate the relationship between the number of metallic cerclage wires used in femoral fracture surgery and the risk of developing deep infections.
- Conditions
- Femur Fracture, Periprosthetic Fracture of Hip, Periprosthetic Fracture of the Femur, Surgical Site Infection (SSI)
- Trial name
- C-INFECT (NCT07434258)
- Testing
- 1 Metallic Cerclage Wiring, 2 metalic cerclage wire, 3 metalic cerclage wire
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Trauma Blunt, Orthopedic
The Healing and Empowerment Actions for Recovery From Trauma (HEART) Trial
The HEART Trial aimed to determine if wrap-around psychosocial support for patients who sustain moderate to severe trauma requiring orthopedic surgery intervention improves outcomes for patients (Aim 1), care-partners (Aim 2)…
- Trial name
- HEART (NCT07584252)
- Testing
- Comprehensive trauma recovery programming (C-TRP), Standard of Care (Investigator Selected)
- Where
- 7 sites in United States
- Volunteers
- 804 people
- Sponsor
- Stephanie Di Stasi