Clinical trials: Orthopedic Surgeries
Postoperative Pain Management
A Phase 2 Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment in Orthopedic Surgery
This is a multi-center, randomized, double-blind, placebo/active-controlled study. 160 subjects undergoing orthopedic surgery under general anesthesia are planned to be enrolled and randomized into the HSK21542 group, morphine…
- Trial name
- NCT07442877
- Testing
- HSK21542 dose level 1, HSK21542 dose level 2, morphine
- Where
- 27 sites in China
- Volunteers
- 161 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Coronary Artery Disease, Cerebral Vascular Disease
Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients
This is a non-randomized, non-interventional pilot observational study designed to follow high-risk patients through their surgical and hospital stay.
- Conditions
- Coronary Artery Disease, Cerebral Vascular Disease, Peripheral Artery Disease, Renal Insufficiency
- Trial name
- NCT01809730
- Where
- United States
- Sponsor
- NYU Langone Health
Pain, Postoperative
Monitoring Postoperative Pain and Recovery Following Orthopedic Surgery
This pilot study will seek to use emotion recognition technology from video to link patient facial expressions, heart rate and respiratory rate changes, and movement patterns to patient pain scores.
- Trial name
- NCT02316951
- Testing
- single-arm study group
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Pain, Postoperative
Dose Response Study of Dexmedetomidine in Orthopaedic Spine Surgery Patients
To study the multimodal protocol combining adjunct dexmedetomidine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral…
- Trial name
- DoserespDex (NCT02454881)
- Testing
- Dexmedetomidine, Oxycodone
- Where
- Finland
- Volunteers
- 107 people
- Sponsor
- Turku University Hospital
Orthopedic Surgery
The Impact of a Neutral Formulated and Designed Package Insert on Nocebo-effect.
Background The nocebo effect describes the association between the expectation of negative effects, (e.g. side effects) and the actual occurrence of negative effects.
- Trial name
- NEUPANO (NCT03428035)
- Testing
- Package Insert
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Witten/Herdecke
Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia, Orthopedic Hip Sugery in Eldely Patients
Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal Hypotension
This prospective randomized double-blinded clinical trial aims to compare the efficacy and hemodynamic effects of prophylactic norepinephrine infusion versus phenylephrine infusion for prevention of spinal anesthesia-induced…
- Trial name
- NCT07662408
- Testing
- Norepinephrine, Phenylephrine
- Where
- Egypt
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Sohag University
Osteoarthritis, Gonarthrosis
Multimodal Geriatric Pre-authorization Before Scheduled Orthopedic Surgery
The main objective of this multicentric, prospective and interventional study is to assess the feasibility of multimodal prehabilitation in patients aged 75 years or older with surgical indication for coxarthrosis or severe…
- Trial name
- PRE4OS (NCT05062109)
- Testing
- Multimodal geriatric prehabilitation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Gérond'if
Pulmonary Embolism, Deep Vein Thrombosis
Study to Develop a Reliable Nomogram That Incorporates Clinical and Genetic Information
In this research study, the investigators are trying to find a better way to set the dose of a common blood-thinning medication.
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Atrial Fibrillation
- Trial name
- NCT00401414
- Testing
- Warfarin
- Where
- 2 sites in United States
- Volunteers
- 344 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure
Paracrine Mechanisms of Bone Marrow Stem Cell Signalling in Chronic Heart Failure
The investigators hypothesize that chronic heart failure is associated with a general stem cell dysfunction, which translates into reduced paracrine function of adult stem cells from patients with chronic heart failure as…
- Trial name
- BM-CHF (NCT01086787)
- Testing
- Surgery
- Where
- 2 sites in Italy, Netherlands
- Volunteers
- 125 people
- Sponsor
- University Medical Center Groningen
Total Hip or Knee Arthroplasty
Transfusion Requirements in Orthopedic Surgery (PHASE 2)
The objective of our research program is to determine the transfusion threshold required to maximize functional recovery after major orthopedic surgery (total hip/knee replacement) in these, most often, elderly patient with…
- Trial name
- TRIOS (NCT00726349)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 305 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Red Blood Cells Transfusion.
Restrictive Versus Liberal Red Cell Transfusion Strategy in Orthopedic-Oncology Patients Undergoing Surgery - a Randomized Controlled Study
The rationale for perioperative red blood cell (RBC) transfusion is based on the observation that anemia is an independent risk factor for morbidity and mortality after cardiac operations.
- Trial name
- NCT01491308
- Testing
- Red blood cells transfusion
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Anesthesia; Functional
Ultrasound-assisted Spinal Anesthesia in Midline Versus Paramedian Approach in Adult Orthopedic Surgery
This study aims to compare between the two methods (midline and paramedian approach of spinal anesthesia guided by ultrasound) by the number of needle passes required to successful dural puncture.
- Trial name
- NCT07047469
- Testing
- Group (1): spinal anesthesia with median approach, Group (2): spinal anesthesia with paramedian approach
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Sohag University
Osteoarthritis, Cardiovascular Disease
Risk Factor Control Before Orthopedic Surgery
This trial is designed to determine the best preoperative management strategy for patients undergoing orthopedic surgery.
- Trial name
- OPTMIZE-OS (NCT01837069)
- Testing
- Metoprolol, Lisinopril, Atorvastatin
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- NYU Langone Health
Anxiety, Orthopedic Disorder
Compare Patients' Perception of Surgical Experience Based on Garment
This study seeks to compare how patients rank perception of anxiety, modesty, dignity and overall satisfaction when patients are provided with either a standard patient gown or a standard patient gown plus a pair of specialized…
- Trial name
- NCT05015569
- Testing
- COVR Medical Garment, Standard Patient Gown
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- More Foundation
Postoperative Pain, Upper Extremity Fracture
Ropivacaine Alone Versus Ropivacaine Plus Lidocaine With or Without Epinephrine for Supraclavicular Brachial Plexus Block in Upper Limb Orthopedic Surgery
This randomized controlled trial compared three local anesthetic solutions for ultrasound-guided supraclavicular brachial plexus block in adults aged 18 to 59 years undergoing upper limb orthopedic and trauma surgery at a general…
- Conditions
- Postoperative Pain, Upper Extremity Fracture, Anesthesia, Conduction
- Trial name
- NCT07907666
- Testing
- ropivacaine, lidocaine, lidocaine with epinephrine
- Where
- Mexico
- Volunteers
- 138 people
- Sponsor
- Instituto Mexicano del Seguro Social
Acute Postoperative Pain
Preemptive Analgesia of Gabapentoids in Orthopedic Surgery
To address the preemptive analgesic effect of preoperative gabapentoids versus no gabapentoids in orthopedic surgery
- Trial name
- NCT04775992
- Testing
- gabapentoids
- Volunteers
- 1,000 people
- Sponsor
- King Saud University
Post-operative Pain
FDA: Lowering Orthopedic Opioid Dosing (FLOOD)
This randomized trial evaluates an intervention to minimize use of opioids following total hip and total knee replacement. Half the participants will receive an intervention (mailed educational materials, followed by a pharmacist…
- Trial name
- FLOOD (NCT02576392)
- Testing
- Intervention
- Volunteers
- 561 people
- Sponsor
- Kaiser Permanente
Blood Transfusion, Orthopedic Procedures
A Study to Determine the Safety of Epoetin Alfa and Whether Epoetin Alfa Can Reduce the Need for Blood Transfusions in Patients After Major Orthopedic Surgery.
The purpose of this study is to determine the safety of epoetin alfa and to determine the effectiveness of epoetin alfa in reducing the need for blood transfusions after major orthopedic surgery.
- Conditions
- Blood Transfusion, Orthopedic Procedures, Anemia
- Trial name
- NCT00270036
- Testing
- epoetin alfa
- Volunteers
- 1 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Nerve Block, Lumbar Plexus
Evaluation of Lumbar Plexus Block Success With Near Infrared Spectroscopy (NIRS)
Tests such as the pin-prick test, cold application or the Bromage scale are currently used to measure the success of nerve blocks and are considered subjective assessments as they require verbal consent from the patient.
- Conditions
- Nerve Block, Lumbar Plexus, Near Infrared Spectroscopy
- Trial name
- NCT06126133
- Testing
- Near Infrared Spectroscopy
- Volunteers
- 40 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Patella Fracture, Surgery
Tension Band Versus Locking Plate Fixation for the Treatment of Patella Fractures
This study is a multicenter pragmatic, prospective, assessor-blinded, randomized independent clinical trial in which we compare locking plate fixation to standard tension band fixation in patients with patella fractures.
- Conditions
- Patella Fracture, Surgery, Orthopedic Disorder
- Trial name
- TENPLA (NCT04891549)
- Testing
- Tension band fixation, Plate fixation
- Where
- 6 sites in Denmark
- Volunteers
- 122 people
- Sponsor
- Rasmus Elsøe