Clinical trials: Orthopedic Surgeries
Surgery, Acute Phase Reaction
Neuroinflammation and Cognitive Dysfunction After Orthopedic Surgery
The primary hypothesis that orthopaedic surgery induces a neuroinflammatory response within 48 hours after elective hip or knee surgery and that there is an association between exaggerated CNS inflammatory response or impaired…
- Trial name
- NCT02759965
- Where
- 2 sites in Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska University Hospital
Remimazolam, Orthopedic Procedures
Effective Dose of Remimazolam for Sedation in Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
Currently used drugs for monitored general anesthesia include propofol, midazolam, and dexmedetomidine. Each drug has different advantages and disadvantages.
- Conditions
- Remimazolam, Orthopedic Procedures, Sedatives, Anesthesia, Spinal
- Trial name
- NCT05379777
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Asan Medical Center
Hemostasis
HEMOBLAST Pivotal Clinical Investigation
The purpose of this prospective, randomized, controlled study is to evaluate the safety and efficacy of a new hemostatic device (HEMOBLAST™ Bellows) compared to a control device, absorbable gelatin sponge USP with thrombin.
- Trial name
- NCT02780869
- Testing
- HEMOBLAST Bellows, Absorbable gelatin sponge, USP with thrombin
- Where
- 17 sites in United States
- Volunteers
- 258 people
- Sponsor
- Biom'Up France SAS
Upper Extremity Trauma
Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on Post-operative Opioi
Effective post-operative pain control can reduce patient morbidity and affect the patient outcome. Brachial plexus block is one of them, a popular and widely employed regional nerve block technique for perioperative anesthesia…
- Trial name
- NCT03372486
- Testing
- Bupivacaine plus naloxone, Bupivacaine
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Mansoura University
Infection of Total Knee Joint Prosthesis
Evaluating Bactisure Wound Lavage in Orthopedic Wounds
To demonstrate a reduction of debris in knee synovial fluid as demonstrated by WBC cell counts before and after irrigation with Bactisure Wound Lavage.
- Trial name
- NCT03192124
- Testing
- Bactisure
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Zimmer Biomet
Lower Extremity Surgery
Postoperative Quality of Recovery After Combined Lumbar Plexus-Sciatic Nerve Block (LPB-SNB)
The goal of this clinical trial is to evaluate the efficacy of lumbar plexus-sciatic nerve block (LPB-SNB) by comparing the postoperative quality of recovery as assessed by the Quality of Recovery-40 (QoR-40) questionnaire, in…
- Trial name
- NCT06301503
- Testing
- USG Guided Combined LPB-SNB with Isobaric Bupivacaine, Control
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Udayana University
Pain, Postoperative, Orthopedic Disorder
Gabapentin as Adjuvant for Postoperative Pain in Pediatric Orthopedic Surgery
This study is a clinical trial, prospective, randomized and double-blinded. Gabapentin oral 10 mg/kg was administered to reduce the pain intensity as well as the opioid consumption in children from 3 months to 16 years submitted…
- Trial name
- NCT03005483
- Testing
- Gabapentin
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil Albert Sabin
Cerebral Perfusion, Cerebral Oxygenation
Evaluation of Cerebral Oxygenation During Orthopedic Surgeries Performed in the Beach Chair Position Under General Anesthesia
The goal of this observational study is to determine the correlation between cerebral oxygenation values measured by near-infrared spectroscopy (NIRS) and other routine monitoring parameters in patients placed in the semi-sitting…
- Conditions
- Cerebral Perfusion, Cerebral Oxygenation, Hemodynamic Monitoring, Semi-sitting Position
- Trial name
- NCT07270341
- Testing
- Near-Infrared Spectroscopy (NIRS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Akdeniz University
Cardiovascular Diseases
Effect of Rehabilitation on Ejection Fraction (FE) in Cardiopathic and Non Cardiopathic Patients Undergoing Major Orthopedic Surgery
It is a trial aimed to evaluate the ejection fraction in the preoperative phase and during follow-up in two groups of subjects undergoing major orthopedic surgery: the first consisting of subjects without history of cardiac…
- Trial name
- NCT03413345
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Post Operative Pain
Comparison of Postoperative Analgesic Effect of Intrathecal Magnesium and Fentanyl Added to Bupivacaine in Patients Undergoing Lower Limb Orthopedic Surgery
Magnesium has been suggested that NMDA (N-methyl D-aspartate)receptor antagonists induce preemptive analgesia when administrated before tissue injury , thus decreasing the subsequent sensation of pain.
- Trial name
- NCT01205997
- Testing
- Fentanyl, magnesium sulphate
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Qazvin University Of Medical Sciences
Atelectasis
Air Test In Diagnosis Of Postoperative Lung Atelectasis
Postoperative pulmonary complication represent asignificant source of morbidity and have greater incidence and costs than cardiac complications alone .Atelectasis is the commonest one.
- Trial name
- NCT04458623
- Testing
- Air Test
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Anesthesia, Spinal
Prediction of Hypotension Using Perfusion Index Following Spinal Anesthesia
It is aimed to investigate whether the perfusion index (PI) can predict hypotension after spinal anesthesia in elderly patients as much as in non-elderly patients.
- Trial name
- NCT06427382
- Testing
- Perfusion index
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Femur Fracture
Utility of Pulmonary Echography for Evaluation of Patients Undergoing Orthopedic Surgery for Femur Fracture
The stratification of perioperative risk is an essential moment in the preoperative evaluation of the patient undergoing surgery especially in the setting of urgency.
- Trial name
- LUSHIP (NCT04074876)
- Testing
- Pulmonary echography
- Where
- Italy
- Volunteers
- 877 people
- Sponsor
- University of Udine
Geriatric
Assessment for GEriatric Trauma Patients
Hip fracture is the second indication of surgical management elderly patients. It remains linked with a one-year mortality of 20%-25% according to diiferent governmental agencies, and the incidence reaches 30% for those over 80…
- Trial name
- PAGET (NCT03202589)
- Testing
- FOCUS Echocardiography
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Montpellier
Other Conditions That May Be A Focus of Clinical Attention
Effectiveness of Buddhist Intergrated Group Intervention on Minefulness in Adolescents
The pupose of the study is to determine the effectiveness of the Buddhist integrated group intervention improve the mindfulness in adolescents by a randomized controlled trial.The study divede the adolescents in two groups group…
- Trial name
- NCT01605604
- Testing
- buddhist mind fullness
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Infection Prosthesis Hip and Knee, Infection, Prosthesis Related
Results of Extended Versus Single Dose Antibiotic Prophylaxis In Orthopedic Revision Arthroplasty in Nijmegen.
The goal of this randomized control trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
- Conditions
- Infection Prosthesis Hip and Knee, Infection, Prosthesis Related, Joint Infection, Infection, Surgical Site
- Trial name
- REViSION (NCT06402591)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 751 people
- Sponsor
- Radboud University Medical Center
Surgical Wound, Upper Extremity Injury
Suture Closure Trial
Closure of surgical incisions in orthopedic procedures contributes to patient postoperative pain and risk of complication. As the focus on improving orthopedic surgery outcomes shifts to best practices in postoperative pain…
- Trial name
- NCT05261425
- Testing
- Monocryl buried, Nylon (FDA Approved) not buried
- Where
- 3 sites in United States
- Volunteers
- 160 people
- Sponsor
- Emory University
Surgery
Study of Sutures Versus Staples for Skin Closure After Surgical Procedures of Hip
Skin closure either by sutures or staples is required after any surgical procedure of the hip. The purpose of this study is to compare the amount of drainage between patients who have had either staples or sutures placed for skin…
- Trial name
- NCT00273715
- Testing
- Surgical wound closure techniques, Surgical wound closure techniques (Comparator)
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- University of Kentucky
Constipation, Perioperative Nursing
Effect of a Constipation Prevention Checklist in Hip Surgery Patients
Constipation is a common postoperative problem in patients undergoing hip surgery and may be associated with immobilization, opioid analgesic use, and inadequate fluid and fiber intake.
- Conditions
- Constipation, Perioperative Nursing, Checklist, Orthopedic Disorder
- Trial name
- NCT07895316
- Testing
- Constipation prevention and checklist monitoring in hip surgery patients
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Hip Fracture
Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery?
Does tranexamic acid improve the perioperative care of those patients treated surgically for hip fracture by decreasing the proportion of patients requiring transfusion and decreasing total perioperative bleeding.
- Trial name
- NCT01714336
- Testing
- tranexamic acid
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Mayo Clinic