Clinical trials: Orthopedic Surgeries
Surgical Site Infection
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
The purpose of this study is to see whether applying povidone iodine (PVI) to the noses of patients undergoing lower extremity (leg, ankle, or foot) orthopedic fixation procedures of high-energy lower extremity fractures (HELEF)…
- Trial name
- POTENT (NCT05763602)
- Testing
- povidone-iodine topical ointment
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Loreen Herwaldt
Fascicular Block, Motor Activity
The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine
The purpose of this study is to determine whether different clonidine concentration on axillary brachial plexus block with 1,5% lidocaine for upper limb surgery may influence the sensory and motor block onset time and duration…
- Conditions
- Fascicular Block, Motor Activity, Pain, Postoperative, Latency Period
- Trial name
- NCT01620112
- Testing
- high Clonidine concentration, low clonidine concentration, Lidocaine
- Volunteers
- 60 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Pain, Postoperative
Efficacy and Safety of Intranasal Morphine for Pain After Elective Orthopedic Surgery
Multiple-center, multiple-dose, randomized, double-blind, six-arm, active- and placebo-controlled study in patients with moderate to severe post-surgical pain from elective orthopedic surgery with safety observed for a total of…
- Trial name
- NCT00390039
- Testing
- Intranasal Morphine, IV morphine
- Where
- 7 sites in United States
- Volunteers
- 256 people
- Sponsor
- Javelin Pharmaceuticals
Healthy Spine, Posture
Assessing the Socio-Psychological Determinants of Sagittal Balance
The research focuses on describing the association between socio-psychological factors, collected through standardized self-questionnaires, and the postural alignment of patients without spinal pathology consulting in the…
- Conditions
- Healthy Spine, Posture, Sagittal Balance, Socio-Psychological Factors
- Trial name
- PSYPOS 2 (NCT07024121)
- Testing
- Patient consulting in spine surgery
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Beta Lactam Adverse Reaction
Optimization of Perioperative Antibiotic Prophylaxis in Patients Allergic to Beta-lactams in the Orthopedic Surgery and Trauma Departments
When surgery is required, a consultation with an anesthesiologist is mandatory. This preoperative consultation allows for the selection of the appropriate antibiotic prophylaxis tailored to the patient and the type of procedure.
- Trial name
- ORTHO-PEN (NCT07342647)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Orthopedic Surgery
Pharmacokinetics of Fondaparinux in Patients With Major Orthopedic Surgery
Fondaparinux is a synthetic antithrombotic agent with specific anti-factor Xa activity. A population pharmacokinetic model of fondaparinux, based on data obtained in patients included in phase II/III trials, has been described.
- Trial name
- POP-A-RIX (NCT01063543)
- Where
- 8 sites in France
- Volunteers
- 997 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Smoking Cessation, Fracture
Smoking Cessation Intervention in Acute Orthopedic Surgery
The purpose of this study was to evaluate if an intervention with smoking cessation starting during the acute hospitalization period and continuing during the acute postoperative phase of 6 weeks would reduce the frequency of…
- Trial name
- NCT00704015
- Testing
- Smoking cessation
- Volunteers
- 105 people
- Sponsor
- Karolinska Institutet
Goal Directed Fluid Therapy
Assisted Fluid Management in Patients Undergoing Major Abdominal and Orthopedic Surgery
This study will compare a group of patients managed with a manual GDFT protocol (using the EV1000 monitoring device; Edwards Lifesciences, Irvine, USA) to a group of patients managed using a decision support system for GDFT…
- Trial name
- AFM (NCT03779373)
- Testing
- Use of a decision support system on the EV1000 monitor (AFM mode)
- Where
- France
- Sponsor
- Erasme University Hospital
Postoperative Cognitive Dysfunction
The Effect of Ketamine on Postoperative Cognitive Dysfunction.
Available evidence suggests that there is no significant difference in the incidence of postoperative cognitive dysfunction POCD when general anaesthesia and regional anaesthesia are compared[13, 14].
- Trial name
- NCT04321746
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Postoperative Pain
Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery
The goal of this clinical trial] is to further explore the effectiveness and safety of oxelidine in the treatment of moderate to severe acute pain after orthopedic surgery.
- Trial name
- NCT06320041
- Testing
- Low dose oxelidine group, High dose oxelidine group, Hydromorphone group
- Where
- China
- Volunteers
- 162 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Shivering
Comparative Study Between the Prophylactic Intravenous Administrations of Acetaminophen vs Dexamethasone vs Pethidine Regarding the Incidence of Shivering Induced by Single Shot Spinal Anesthesia in the Orthopedic Surgeries of the Lower Limbs
Single Shot Spinal anesthesia (SSSA) is associated with considerable perioperative shivering and can be challenging to treat. Some pharmacologic agents like N-methyl d-aspartate receptor antagonists, magnesium sulfate and opioid…
- Trial name
- NCT05284409
- Testing
- Pethidine, Acetaminophen, Dexamethasone
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Constipation
Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation
Patients requiring opioids for post-operative pain control following elective orthopedic procedures which has resulted in constipation symptoms, and who are in inpatient rehabilitation will be randomized to two different…
- Trial name
- NCT00662363
- Testing
- Lubiprostone, Senna
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Shirley Ryan AbilityLab
Venous Thromboembolism
Xarelto for VTE Prophylaxis After Hip or Knee Arthroplasty
The main goal is to provide additional information to the risk-benefit assessment of the drug.
- Trial name
- XAMOS (NCT00831714)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Standard care treatment for VTE prophylaxis
- Where
- 42 sites in Australia, Austria and 40 more
- Volunteers
- 19,076 people
- Sponsor
- Bayer
Pain, Postoperative
An Efficacy and Safety Study to Compare Fentanyl Ionsys and Routine Care With Intravenous (IV) Morphine Patient-controlled Analgesia (PCA) in Participants Who Have Undergone Elective Major Abdominal or Orthopedic Surgery
The purpose of this study is to evaluate the mobilization characteristics, clinical use, safety and Ease of Care (EOC) of a fentanyl Iontophoretic Transdermal Patient Controlled Analgesia (PCA) system (Ionsys) and morphine…
- Trial name
- NCT00766506
- Testing
- Fentanyl IONSYS, Morphine IV PCA
- Where
- 7 sites in United Kingdom
- Volunteers
- 108 people
- Sponsor
- Janssen-Cilag Ltd.
Local Analgesia Via Infiltration
A Study of Bupivacaine Liposome Injection in Local Analgesia of Pediatric Patients
The study is being conducted to evaluate the safety and efficacy of bupivacaine liposome injection for local infiltration analgesia in pediatric orthopedic surgery in the real world.
- Trial name
- NCT06344091
- Testing
- Bupivacaine Liposome Injection
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Hospitalization in Cardiology, Orthopaedic Surgery or Endocrinology Departments
Descriptive Study on the Evaluation of Well-being in Relation to Diet and Nutrition and Comparison Between Three Care Units in the Dijon University Hospital Centre
The aim of this study is to qualify patient well-being in relation to diet. The notion of dietary well-being is believed to be subjective and we wish to base it on tangible parameters (presentation of meals, variety of menus…
- Trial name
- ALIMS (NCT03520296)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 440 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Neurosurgery, Orthopedic Surgery
Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery
Spinal surgery may be associated with substantial blood loss which often requires erythrocyte transfusion. Transfusion of red blood cells (RBC) is not free of adverse events and has been associated with increased risks of…
- Conditions
- Neurosurgery, Orthopedic Surgery, Red Blood Cell Transfusion
- Trial name
- NCT01258010
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Knee Surgery, Shoulder Surgery
Changes in Anthropometry Following Ambulatory Orthopaedic Surgery
The purpose of this research is to study changes in weight, body mass index, and percentage of fat following orthopaedic knee or shoulder surgery.
- Trial name
- CAS (NCT02435251)
- Testing
- dual energy X-ray absorptiometry
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Anesthesia; Functional
Ultrasound-assisted Spinal Anesthesia in Midline Versus Paramedian Approach in Adult Orthopedic Surgery
This study aims to compare between the two methods (midline and paramedian approach of spinal anesthesia guided by ultrasound) by the number of needle passes required to successful dural puncture.
- Trial name
- NCT07047469
- Testing
- Group (1): spinal anesthesia with median approach, Group (2): spinal anesthesia with paramedian approach
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Sohag University
Venous Thromboembolism
An Observational Study On The Safety And Tolerability Of Prolonged Thrombosis Prophylaxis With Fragmin®
The objective of this study is to observe the safety, tolerability, and compliance in the use of Fragmin® for prolonged thromboprophylaxis in post-surgery high-risk orthopedic patients.
- Trial name
- NCT01046903
- Testing
- Fragmin® (Dalteparin Sodium)
- Volunteers
- 503 people
- Sponsor
- Pfizer