Clinical trials: Orthopedic Surgeries
Postoperative Pain Management
A Phase 2 Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment in Orthopedic Surgery
This is a multi-center, randomized, double-blind, placebo/active-controlled study. 160 subjects undergoing orthopedic surgery under general anesthesia are planned to be enrolled and randomized into the HSK21542 group, morphine…
- Trial name
- NCT07442877
- Testing
- HSK21542 dose level 1, HSK21542 dose level 2, morphine
- Where
- 27 sites in China
- Volunteers
- 161 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Other Conditions That May Be A Focus of Clinical Attention
Effectiveness of Buddhist Intergrated Group Intervention on Minefulness in Adolescents
The pupose of the study is to determine the effectiveness of the Buddhist integrated group intervention improve the mindfulness in adolescents by a randomized controlled trial.The study divede the adolescents in two groups group…
- Trial name
- NCT01605604
- Testing
- buddhist mind fullness
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Orthopedics
Intraoperative Sedation and Postoperative Delirium
Delirium are common after orthopedic surgery in the elderly and are directly associated with loss of independence, reduction in the quality of life and increased mortality.
- Trial name
- NCT02573558
- Testing
- Dexmedetomidine, Propofol
- Where
- South Korea
- Volunteers
- 855 people
- Sponsor
- Seoul National University Bundang Hospital
Orthopedic Procedures, Pain, Postoperative
Risk Model for Severe Rebound Pain After Lower Limb Orthopedic Surgery Involving Single-Shot Sciatic Nerve Blocks
Rebound pain is a well-recognized phenomenon after the effects of a nerve block wear off. Severe rebound pain can happen after outpatient surgery, with patients often needing to come back to the hospital or use other health care…
- Conditions
- Orthopedic Procedures, Pain, Postoperative, Surgery, Nerve Block
- Trial name
- NCT05018104
- Testing
- This is not an interventional study
- Where
- Canada
- Volunteers
- 1,270 people
- Sponsor
- University of British Columbia
Ischemia Limb, Blood Circulation Disorder
Ischemia Detection During Development of Acute Compartment Syndrome
This is an open, observational, prospective, descriptive, single-centre study including 60 patients. The study is designed to investigate if IscAlert sensor system can be used for reliable and continuous tissue carbon dioxide…
- Conditions
- Ischemia Limb, Blood Circulation Disorder, Carbon Dioxide, Biosensing Techniques
- Trial name
- IDEA (NCT06079255)
- Testing
- IscAlert sensor(s) in patient with risk of acute compartment syndrome
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Hallux Valgus and Bunion, Sedation
Dexmedetomidine Sedation in Orthopedic Surgery
60 patients ASA I-III, undergoing orthopedic surgery will be randomly assigned into one of three groups, namely group A (n=20), where dexmedetomidine will be used for sedation (initial bolus dose followed by continuous infusion)…
- Trial name
- NCT04149626
- Testing
- Dexmedetomidine, Midazolam, Remifentanil
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Asklepieion Voulas General Hospital
Bone Neoplasms, Musculoskeletal Neoplasms
Predicting Allograft Volume in Orthopedic Oncology: Hemielipsoid Formula vs Intraoperative Fluid-Fill Measurement
Bone defects following primary musculoskeletal tumor resection are frequently reconstructed using structural allografts. Allograft availability is limited, and intraoperative waste due to oversized graft selection remains a…
- Conditions
- Bone Neoplasms, Musculoskeletal Neoplasms, Bone Transplantation
- Trial name
- PREDALL (NCT07653178)
- Testing
- Hemielipsoid Formula-Based Preoperative and Intraoperative Bone Defect Volume Estimation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Sakarya University
Deep Vein Thrombosis
A Safety and Efficacy Study of BCD-080 Compared to Clexan for Deep Vein Thrombosis Prophylaxis at Orthopedic Surgeries
The purpose of the study is to prove equivalence of efficacy and safety of BCD-080 and Clexan for deep vein thrombosis and embolism prophylaxis at orthopedic surgeries.
- Trial name
- NCT02368314
- Testing
- Sodium Enoxaparine
- Where
- Russia
- Volunteers
- 124 people
- Sponsor
- Biocad
Postoperative Pain
Safety of the Buprenorphine Transdermal Delivery System in Subjects With Mod-to-Sev Pain Following Orthopedic Surgery.
The objective of this study is to assess the safety of the buprenorphine transdermal system (5, 10, and 20 mg) in comparison to placebo transdermal system in subjects with moderate to severe pain after orthopedic surgery.
- Trial name
- NCT00315835
- Testing
- Buprenorphine transdermal delivery system
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Purdue Pharma LP
Hemodynamics
Gradual Versus Intermittent Release of Tourniquet Effect on MAP in Hypertensive Patients Undergoing Upper Limb Orthopedic Surgeries
In this clinical trial, the authors will compare two tourniquet deflation techniques and their clinical implications on hemodynamics and acid base parameters in hypertensive orthopedic patients undergoing upper limb surgeries…
- Trial name
- NCT07290504
- Testing
- Tourniquet deflation
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Kasr El Aini Hospital
Pain, Postoperative
Morphine-Sparing Effect And Safety Of Parecoxib Administered Intravenously For The Treatment Of Postoperative Pain
To validate the morphine-sparing effect and safety of parecoxib administered intravenously for the treatment of Chinese subjects with postoperative pain following gynecological or orthopedic surgery.
- Trial name
- NCT00143169
- Where
- 8 sites in China
- Volunteers
- 220 people
- Sponsor
- Pfizer
Achilles Tendon Rupture, Database
Barriers to Efficient PACU Discharge at a Major Academic Orthopaedic Ambulatory Surgery Center
This is a retrospective chart review to determine the etiologies contributing to prolonged PACU discharge at a major Orthopedic Ambulatory Center
- Trial name
- NCT04356612
- Testing
- Chart Review
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Pediatric Surgical Patients, Preemptive Epidural Analgesia
The Impact of Preemptive Epidural Analgesia on Acute Postoperative Pain in Pediatric Orthopedic Surgery
Management of postoperative pain is critical in the pediatric patients, however, safe and effective analgesia for pediatric surgical patients remains a challenge.
- Trial name
- NCT02813018
- Testing
- 0.2 ml/kg of 0.2% ropivacaine, 0.2mg/kg of Normal Saline
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Postoperative Pain
Postoperative Pain and Polyamines-poor Diet (DOLAMINE)
Animal studies have shown that the level of pain sensitivity is highly dependent on the amount of polyamines in food. This fundamental observation of a nutritional approach to pain led the authors to develop diets completely…
- Trial name
- DOLAMINE (NCT02592460)
- Testing
- poor-polyamines diet, high polyamines diet
- Where
- France
- Volunteers
- 542 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Adolescent Idiopathic Scoliosis, Cerebral Palsy
Pain Assessment in Children Undergoing Spine Surgery
Musculoskeletal (MSK) pain is one of the most common types of pain among children and adolescents. Recurring episodes of MSK pain conditions have a major impact on the daily lives.
- Trial name
- NCT04244760
- Testing
- Pain assessment for verbal patients, Pain assessment for non-verbal patients
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Catherine Ferland
Deep Vein Thrombosis, Total Hip Prosthesis
Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs
The numerical ratio between the value of the thrombin generation test performed without soluble thrombomodulin and the value of the thrombin generation test performed in the presence of soluble thrombomodulin, performed…
- Conditions
- Deep Vein Thrombosis, Total Hip Prosthesis, Knee Prosthesis
- Trial name
- GT-PT (NCT03634124)
- Testing
- Blood test, Doppler ultrasound
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sleep
Sleep and Performance in Surgeons
The primary aim of this study is to assess the changes in strength expression resulting from the performance of a surgical operation among orthopedic surgeons at the IRCCS Galeazzi-Sant'Ambrogio Hospital.
- Trial name
- Sleep&Surgeon (NCT06213246)
- Testing
- Sleep Hygiene Strategies
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Pain Management
Multimodal Pain Management After Wide Awake Local Anesthesia No Tourniquet Orthopedic Hand Surgery: A Randomized Control Trial
The main objective of the study is to measure the efficacy of a multimodal postoperative pain regimen consisting of oral acetaminophen and naproxen compared to a traditional opioid-only pain regimen following elective wide awake…
- Trial name
- WALANT (NCT06917118)
- Testing
- Oxycodone 5mg taken first, Acetaminophen, Naproxen Tablets, 500 mg
- Where
- Puerto Rico
- Volunteers
- 100 people
- Sponsor
- University of Puerto Rico
Hip Surgery
Effectiveness and Safety of the Electrically Powered Orthopedic Exercise Device on Gait Ability in Patients With Who Have Undergone Hip Surgery
Gait is an essential daily activity performed through the complex coordination of the central and peripheral nervous systems and the musculoskeletal system.
- Trial name
- NCT07147491
- Testing
- Electrically Powered Orthopedic Exercise Device
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Coronavirus Infection, Orthopedic Disorder
Retrospective Case Series of COVID19+ Patients Undergoing Orthopedic Surgery
Over the last months, the Rizzoli Orthopedic Institute in Bologna, Italy, has drained orthopedic urgencies from all other hospitals in the urban and suburban area.
- Conditions
- Coronavirus Infection, Orthopedic Disorder, Bone Fracture, Bone Metastases
- Trial name
- COVID19&SURG (NCT05881343)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli