Clinical trials: Orthostatic Intolerance
Vomiting Syndrome, Irritable Bowel Syndrome
Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea
Retrospectively review the charts of all children who had heart rate variability, deep breathing test, valsalva maneuver, tilt table test, thermoregulatory sweat testing, quantitative sudomotor axon reflex test (QSART) completed…
- Conditions
- Vomiting Syndrome, Irritable Bowel Syndrome, Postural Orthostatic Tachycardia Syndrome, Abdominal Pain
- Trial name
- NCT00728026
- Volunteers
- 19 people
- Sponsor
- Medical College of Wisconsin
Vasovagal Syncope (VVS)
Assesment of the Clinical Benefit of Provocation on Tilt-table in SYNCope Patients, TiltSYNC-trial
multicenter prospective randomized controlled comparison of biofeedback with tilt table testing (investigational management strategy) vs biofeedback without tilt table testing (reference management strategy) in patients with…
- Trial name
- TiltSYNC (NCT07459478)
- Testing
- biofeedback and standard of care with tilt table testing, no tilt table testing
- Where
- Netherlands
- Volunteers
- 238 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Fever, Orthostatic Hypotension
Orthostatic Hypotension in Children With Acute Febrile Illness
Objective:to determent if children suffering from acute febrile illness has higher rate of orthostatic hypotension compared with children with no febrile illness. Design: a prospective cohort study.
- Trial name
- NCT00452712
- Testing
- All subjects will have their blood pressure measured in supine position (after 5 minute of rest) and after 3 minute of standing.
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Postural Tachycardia Syndrome
Dopamine in Orthostatic Tolerance
One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate.
- Trial name
- NCT00748228
- Testing
- dietary sodium
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Parkinson's Disease
The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease
The objective of this experiment is: Primary: To determine the effects of tyrosine supplementation on orthostatic hypotension in people with PD.
- Trial name
- NCT01676103
- Testing
- Tyrosine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- New York Institute of Technology
Long COVID-19, Acute COVID-19
Long COVID-19 Cutaneous Signatures: An ARPA Funded Research Project
This is a prospective, longitudinal study involving 300 participants for a single visit to compare Long COVID-19 neurocutaneous biosignatures with those of other disorders affecting the sensory and autonomic nervous system.
- Conditions
- Long COVID-19, Acute COVID-19, Postural Orthostatic Tachycardia Syndrome (POTS), Diabetic Neuropathy
- Trial name
- LCCS (NCT07005947)
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- CND Life Sciences
Postural Tachycardia Syndrome
Vagal Stimulation in POTS
The purpose of this study is to investigate how the electrical stimulation of a nerve in the skin of the earlobe (transcutaneous vagal nerve stimulation), alone or in combination with two medications (galantamine and…
- Trial name
- NCT03124355
- Testing
- Pyridostigmine Pill, Galantamine Pill, Vagal stimulation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Vanderbilt University Medical Center
Syncope, Vasovagal, Neurally-Mediated
Assessment of the Durability of Cardioneuroablation Using Physiological Indices of Heart Rate Reactivity
Cardioneuroablation is a novel treatment option for reflex-mediated syncope. It involves thermal destruction of neural tissue in the close proximity of heart using catheter introduced to the heart through vein in the groin.
- Trial name
- NCT06697145
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 12 people
- Sponsor
- Wroclaw Medical University
Postural Orthostatic Tachycardia Syndrome
Gabapentin Treatment of Postural Tachycardia Syndrome (PoTS)
In this pilot study, the investigator will test the usefulness of gabapentin in treating some of the symptoms associated with POTS.
- Trial name
- NCT04345432
- Testing
- Gabapentin
- Volunteers
- 10 people
- Sponsor
- Medstar Health Research Institute
Osteoarthrosis
Effect of Methylprednisolone on Orthostatic Intolerance and Heart Rate Variability in Hip-arthroplasty Patients
The study evaluates the pathophysiological effects of a single dose Methylprednisolone administered prior to total hip-arthroplasty (THA) surgery.
- Trial name
- NCT02445898
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Posttraumatic Stress Disorder, Pseudopheochromocytoma
Clinical Autonomic Disorders: A Training Protocol
Background: The autonomic nervous system helps control things that happen automatically in the body, like blood pressure, heart rate, and digestion. When it doesn t work properly, it s called dysautonomia.
- Conditions
- Posttraumatic Stress Disorder, Pseudopheochromocytoma, Healthy Volunteers, Neurocardiogenic Syncope
- Trial name
- NCT02154009
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Syncope, Vasovagal
Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study)
Physiological stimulation therapy effectiveness will be proved with contractility sensor or CLS sensor (Closed Loop Stimulation), in BIOTRONIK CLS pacemakers to prevent from neuromediated syncope.
- Trial name
- SPAIN (NCT01621464)
- Testing
- Pacemaker with Closed Loop Stimulation (CLS sensor)
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Spanish Society of Cardiology
Postural Orthostatic Tachycardia Syndrome
A Shared Medical Appointment Intervention for Quality of Life Improvement in POTS
Postural orthostatic tachycardia syndrome (POTS) is a clinical syndrome encompassing a myriad of debilitating symptoms that does not have any FDA approved drug therapies.
- Trial name
- NCT05454137
- Testing
- Shared medical appointment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arizona
Orthostatic Intolerance, Parkinson's Disease
Treatment of Orthostatic Intolerance in Patients With Parkinson's Disease Using Midodrine
This study will evaluate whether treatment with the α1-agonist, midodrine, reduces subjective orthostatic lightheadedness as measured by the Non-Motor Symptoms Scale for Parkinson's Disease (NMSS) questionnaire, in patients with…
- Trial name
- NCT02365012
- Testing
- Midodrine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Orthostatic Hypotension, Alzheimer Disease
Efficacy, Safety and Response Predictors of Adjuvant Astragalus for Cognition in Orthostatic Hypotension
Background: This pragmatic clinical trial aims to determine the efficacy and safety of add-on Astragalus for cognition and non- cognition in patients with of mild to moderate Alzheimer's disease complicated with orthostatic…
- Trial name
- NCT05647473
- Testing
- Routine treatment, add-on low dose Astragalus, add-on high dose Astragalus
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Fujian Medical University Union Hospital
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Orthostatic Hypotension, Diabetes Mellitus Type 2
Orthostatic Hypotension and Diabetes Mellitus
Rationale: Orthostatic hypotension increases with age and is associated with increased vascular and all-cause mortality. The prevalence of orthostatic hypotension is also increased in diabetic subjects.
- Trial name
- ODET (NCT00807976)
- Where
- Netherlands
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical Research Foundation, The Netherlands
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University