Clinical trials: Orthostatic Tachycardia
Postural Tachycardia Syndrome, Orthostatic Tachycardia
Acute Salt Handling in Orthostatic Intolerance
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control…
- Conditions
- Postural Tachycardia Syndrome, Orthostatic Tachycardia, Orthostatic Intolerance
- Trial name
- NCT00581633
- Testing
- normal saline (0.9%)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Tachycardia, Postural Orthostatic Tachycardia Syndrome
Pathophysiology of Orthostatic Intolerance
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies.
- Trial name
- NCT00608725
- Testing
- DAXOR, QSweat, Intrinsic Heart Rate
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Postural Tachycardia Syndrome
Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome
The purpose of this study is to see if people with Postural Tachycardia Syndrome (POTS) have different levels of certain chemicals in their blood than people who don't have POTS.
- Trial name
- NCT01308099
- Testing
- Blood Pressure and Blood Flow
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Dysautonomia, Anxiety
Implementation of Transdx Group for POTS
The proposed intervention is focused on developing and implementing a psychological approach incorporated into a group-based outpatient intervention for pediatric autonomic dysfunction.
- Conditions
- Dysautonomia, Anxiety, Depression
- Trial name
- NCT03185247
- Testing
- Transdiagnostic Group-Based Treatment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
POTS - Postural Orthostatic Tachycardia Syndrome
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic…
- Trial name
- POTS (NCT05554107)
- Testing
- Training program
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Clonal Mast Cell Disease, KIT D816V Mutation
Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations
This is a multicenter screening study to characterize the prevalence of the KIT D816V mutation in participants with suspected clonal mast cell disease.
- Conditions
- Clonal Mast Cell Disease, KIT D816V Mutation, Suspected KITD816V Mutated Clonal Mast Cell Disease
- Trial name
- POLARIS (NCT07143669)
- Testing
- Screening
- Where
- 26 sites in United States, Belgium
- Volunteers
- 750 people
- Sponsor
- Blueprint Medicines Corporation
Postural Orthostatic Tachycardia Syndrome (POTS), POTS
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Postural tachycardia syndrome (POTS), is the chronic form of orthostatic intolerance associated with excessive upright tachycardia, and occurs predominantly in young females (>85%).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), POTS, Orthostatic Intolerance
- Trial name
- NCT03261570
- Testing
- Pyridostigmine, Digoxin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Orthostatic Hypotension, Heart Rate
Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia Syndrome.
Postural orthostatic tachycardia POTS is characterized by excessive increase in heart rate when moving from lying to standing position, often accompanied by symptoms such as dizziness, fatigue, brain fog, lightheadedness, rapid…
- Conditions
- Orthostatic Hypotension, Heart Rate, Blood Pressure
- Trial name
- NCT07579026
- Testing
- diaphragmatic breathing exercise, educational retraining
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome
POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/CFS
Pilot-case-control study on exertion and orthostatic intolerance of adolescents with myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) compared to age-matched healthy controls (HC).
- Conditions
- Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- POTS-CFS (NCT06054958)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Inappropriate Sinus Tachycardia, Postural Tachycardia Syndrome
Inappropriate Sinus Tachycardia Registry
The primary objective of this registry is to capture real-world safety and performance data on AtriCure devices used to ablate cardiac tissue when treating Inappropriate Sinus Tachycardia (IST) or Postural Tachycardia Syndrome…
- Trial name
- NCT05107635
- Testing
- AtriCure Commercially Available Devices
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 500 people
- Sponsor
- AtriCure, Inc.
Postural Orthostatic Tachycardia Syndrome
A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe POTS
POTS is a relatively common condition that affects millions of patients around the globe. It has an estimated prevalence of 170/100,000 with approximately 80% of patients being women of childbearing age.
- Trial name
- NCT03365414
- Testing
- Albumin (Human) 5%, USP, Normal Saline 0.9% Infusion Solution Bag
- Sponsor
- University of Alberta
Postural Orthostatic Tachycardia Syndrome
Transdermal Vagal Stimulation for POTS
Some patients experience high heart rates and symptoms of light-headedness, fatigue, headache during standing despite well maintained blood pressure. These patient are disabled and can't be in upright position for a longer time.
- Trial name
- NCT02281097
- Testing
- Stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University
Postural Tachycardia Syndrome
The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity
This study is being to see if participating in breathing exercise training and practicing this training will help with Postural tachycardia syndrome (POTS).
- Trial name
- NCT05618067
- Testing
- breathing exercise training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
POTS
POTS Stroke Volume
the investigators propose studies of a tiny, wearable, wireless, beat-to-beat blood pressure monitor that will be both a transformative research platform and an enabler of patient self-care in the diagnosis, investigation, and…
- Trial name
- NCT05796154
- Testing
- ear blood pressure monitor
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Long COVID, Postural Orthostatic Tachycardia Syndrome
The Long COVID-19 Wearable Device Study
To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can…
- Conditions
- Long COVID, Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Myalgic Encephalomyelitis
- Trial name
- NCT05741112
- Testing
- Wearable device
- Where
- United States
- Volunteers
- 100,500 people
- Sponsor
- Scripps Translational Science Institute
Postural Tachycardia Syndrome
fMRI in Postural Tachycardia Syndrome
Postural tachycardia syndrome (POTS) is one of the most common forms of chronic orthostatic intolerance in the United States. This is a disabling disorder characterized by an excessive increase in heart rate upon standing that is…
- Trial name
- POTS (NCT04137757)
- Testing
- Lower Body Negative Pressure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Postural Orthostatic Tachycardia Syndrome, Acute Hepatic Porphyria
Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome
Postural Tachycardia Syndrome (POTS) is the most common autonomic disorder and is estimated to affect 3,000,000 individuals in the United States, with 80-85% of patients being women.
- Trial name
- NCT05344599
- Testing
- Autonomic Function Testing, Genetic Testing, Urine Testing
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Vanderbilt University Medical Center
Postural Orthostatic Tachycardia Syndrome (POTS)
Beta-3 Enhanced Autonomic Therapy for POTS
The study will test the hypothesis that mirabegron is more effective than a placebo in alleviating postural orthostatic tachycardia (POTS) symptoms.
- Trial name
- BEAT-POTS (NCT07585513)
- Testing
- Mirabegron
- Volunteers
- 36 people
- Sponsor
- Cedars-Sinai Medical Center
Postural Orthostatic Tachycardia Syndrome
Dietary Salt in Postural Tachycardia Syndrome
Patients with POTS may not adequately expand their plasma volume in response to a high-sodium (Na+) diet. Mechanisms involved in the regulation of plasma volume, such as the renin-angiotensin-aldosterone system and renal…
- Trial name
- NCT01547117
- Testing
- Blood Volume, Total Blood Volume, Exercise Capacity Test - Bicycle
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Postural Orthostatic Tachycardia Syndrome
Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.
- Trial name
- NCT06292104
- Testing
- multimodal diagnostic testing
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center