Clinical trials: Osteoarthritis, Knee
Knee Osteoarthritis
Effect of Pre-surgery Neuromuscular Physiotherapy (PT)
Background: Osteoarthritis (OA) is a common degenerative condition of large weight-bearing joints, such as the hip and knee, as well as small hand joints.
- Trial name
- Omega (NCT00913575)
- Testing
- preoperative neuromuscular training, knee OA School
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- University of Zurich
Knee Osteoarthritis
Comparison of the Effects of Basic Body Awareness Therapy in Individuals With Knee Osteoarthritis
Osteoarthritis (OA) is a chronic, degenerative joint disease associated with aging and is recognized by the World Health Organization as a primary health condition. It is one of the leading causes of chronic disability worldwide.
- Trial name
- NCT07395427
- Testing
- BBAT plus home exercise programme, Conventional physiotherapy plus home exercise programme, Home exercise programme
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Hacettepe University
Chronic Pain, Osteoarthritis of the Knee
Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee
The objective of this study is to determine the analgesic efficacy and safety of Buprenorphine Transdermal System (BTDS) 10 and 20 compared to placebo in opioid-naïve subjects with moderate to severe chronic pain due to…
- Trial name
- NCT00531427
- Testing
- Buprenorphine
- Where
- 87 sites in United States
- Volunteers
- 567 people
- Sponsor
- Purdue Pharma LP
Knee Osteoarthritis, Metabolic Disease
Bracing for Patellofemoral Osteoarthritis
BACKGROUND: Despite the prevalence of patellofemoral ostearthritis (OA), this joint has received relatively little attention in the OA literature and there are few treatment options for individuals with patellofemoral OA.
- Trial name
- NCT02984254
- Testing
- Womac, Lequesne, Timed-up-and-go (TUG)
- Volunteers
- 52 people
- Sponsor
- University of Sao Paulo General Hospital
Arthrosis of the Knee
The Importance of Different Modularity of the Polyethylene Insert for Tibial Component Migration and Adaptive Bone Remodeling After Uncemented Total Knee Arthroplasty Using Trabecular Metal Technology (TMT) Zimmer NexGen®, (Monoblock vs. Modular Design)
In a prospective randomised study two uncemented tibial components with different polyethylene modularities (Trabecular Metal Technology (TMT) Zimmer NexGen® monobloc and TMT Zimmer NexGen® modular) used for total knee…
- Trial name
- NCT01637051
- Testing
- Zimmer NexGen® Trabecular Metal Technology (TMT), Monoblock, Zimmer NexGen® Trabecular Metal Technology (TMT), Modular
- Where
- 2 sites in Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
the Treatment of Knee Osteoarthritis
Intra-articular Administration of Med Device Made of Biological Vegetal Matrix for the Treatment of Knee Osteoarthritis
A pre-market randomized, parallel group, single-blind, clinical study with a Medical Device, made of vegetal material, to evaluate the efficacy and safety of one knee injection of the investigational device versus active…
- Trial name
- NCT05925595
- Testing
- Medical Device Iniettabile Ginocchio
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Bios-Therapy, Physiological Systems for Health S.p.A
Knee Osteoarthritis
Center-based Physical Therapy and Home-based Physical Therapy After Platelet Rich Plasm Injection
Osteoarthritis (OA) of the knee is a chronic disease characterized by pain, reduced range of motion, instability and effusion in the joint.
- Trial name
- NCT05033977
- Testing
- Exercise (center-based), Exercise (home-based)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Knee Osteoarthritis, Arthropathy of Knee Joint
The Effect of Exercise Training on Muscle Mass in Patients With Total Knee Arthroplasty
Background: Total knee arthroplasty (TKA) is one of the most common operations in orthopedics. After surgery, the decline of bone mineral density and muscle mass was proved, oral bisphosphonate is commonly used to prevent BMD…
- Trial name
- NCT03339323
- Testing
- Exercise
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- Chang Gung Memorial Hospital
Knee Osteoarthristis
BFR Training and Knee Osteoarthritis
Knee osteoarthritis (KOA) is a chronic, progressive degenerative joint disease characterized by cartilage and bone degeneration, synovial inflammation, and structural changes.
- Trial name
- NCT07590323
- Testing
- Standard Treatment, Pain neuroscience education, Blood flow restriction training
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- University of Hail
Knee Osteoarthritis
Wearable Sensor-based Balance Training for Patients With Knee Osteoarthritis
Knee osteoarthritis (KOA) is one of the leading causes of lower limb disability among the elderly and can cause loss of knee joint proprioception that contributes towards deterioration of postural balance.
- Trial name
- NCT02620462
- Testing
- Wearable sensor-based exercise training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Arizona
Scale Reliability Validity, ACL Injury
Validation and Cultural Adaptation of the KOOS-ACL Scale for the Italian Population
Submission of the KOOS ACL questionnaires in Italian for the purpose of validation and cultural adaptation of the KOOS-ACL scale for the Italian population.
- Conditions
- Scale Reliability Validity, ACL Injury, Validation and Cultural Adaptation of a Scale, PROMs
- Trial name
- VACKP (NCT07386405)
- Testing
- PROMS submition
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteo Arthritis Knee
Incorporating Patient-Reported Outcomes Into Shared Decision Making With Patients With Osteoarthritis of the Hip or Knee
Osteoarthritis (OA) of the knee constitutes a major public health problem. Treatment options for knee OA range from lifestyle changes to pharmacological management to total knee replacement surgery.
- Trial name
- NCT04805554
- Testing
- Joint Insights decision aid
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Knee Osteoarthritis
The Effect of Training With Custom-Made Biomechanical Perturbation Platform on Kinetics, Kinematics and Electromyography in Knee Osteoarthritis Patients
The aim of this study is to evaluate the outcome of specific repetitive biomechanical perturbation training on motor patterns. The first hypothesis of this project is that footwear derived biomechanical challenges will convey…
- Trial name
- NCT00724139
- Testing
- : APOS biomechanical gait system, Apos - Sports and Medical Technologies Ltd. Hertzlia, Israel
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- HaEmek Medical Center, Israel
Osteoarthritis, Obesity
Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- IM-LOSEIT-II (NCT02928679)
- Testing
- Liraglutide 3 mg (Saxenda)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Henrik Gudbergsen
Knee Osteoarthritis
Resistance Exercise in Severe Knee Osteoarthritis
This study aim to evaluate pain after different resistance training protocols (placebo, 4 sets of 10RM, 8 sets of 10 RM and 12 sets of 10RM) in patients with severe knee osteoarthritis.
- Trial name
- RTOA (NCT06664905)
- Testing
- Resistance Exercise
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Valencia
Osteoarthritis, Knee, Osteoarthritis, Hip
Study Evaluating the Efficacy of Joint Replacement
Patient-related outcomes were originally designed to measure outcomes in clinical studies. They were not developed to predict outcomes, however, different studies showed close association between values achieved preoperatively…
- Trial name
- SEVERE (NCT04691466)
- Testing
- Joint replacement
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Nicolaus Copernicus University
Hip Osteoarthritis, Knee Osteoarthritis
Pilot RCT Comparing Effectiveness of Two Decision Aids for Hip and Knee Osteoarthritis
This pilot RCT study is to examine the comparative effectiveness of two decision aids for hip and knee osteoarthritis.
- Trial name
- NCT02625402
- Testing
- Brief interactive decision aid, Long video decision aid
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Massachusetts General Hospital
Osteoarthritis
Validation Study to Investigate the Effect of a New Treatment in Patients With Osteoarthritic Pain
The purpose of this clinical trial conducted in patients suffering from chronic pain is to study the relationship between individual patients' profile and their analgesic response
- Trial name
- NCT03174145
- Testing
- Positive behaviour, T4P1010 administration, Pharmacogenetic
- Where
- 6 sites in Belgium, France and 1 more
- Volunteers
- 73 people
- Sponsor
- Tools4Patient
Osteo Arthritis Knee, Osteoarthritis, Hip
Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions
Knee and hip osteoarthritis (OA) is the most common cause of disability in the U.S. and affects more than 60% of adults over 65 years.
- Trial name
- NCT03102580
- Testing
- OA Care Plan
- Where
- United States
- Volunteers
- 5,713 people
- Sponsor
- University of Massachusetts, Worcester
Osteoarthritis (OA) of the Knee
The Efficacy of Transcutaneous Pulsed Radiofrequency Acupuncture for Knee Osteoarthritis
Efficacy of transcutaneous acupoint pulsed radiofrequency with rehabilitation for knee osteoarthritis.
- Trial name
- NCT06702046
- Testing
- transcutaneous pulsed radiofrequency acupuncture
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
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