Clinical trials: Osteoarthritis, Spine
Ankylosing Spondylitis
Safety and Efficacy Study of Umbilical Cord/Placenta-Derived Mesenchymal Stem Cells to Treat Ankylosing Spondylitis (AS)
The purpose of this study is to evaluate the safety and efficacy of mesenchymal stem cells (MSCs) derived from human umbilical cord/placenta at a dose of 1.0E+6 MSC/kg in subject for the therapy of Ankylosing spondylitis (AS)
- Trial name
- NCT01420432
- Testing
- Human umbilical cord-derived MSCs
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shandong University
Ankylosing Spondylarthritis
Ankylosing Spondylitis and Antiphospholipid Antibodies
The main objective is to evaluate the prevalence of anti-phospholipid antibodies (APLA) in patients with ankylosing spondylitis (AS).
- Trial name
- ASAA (NCT02809300)
- Testing
- blood collection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CHU de Reims
Psoriatic Arthritis
PsA Secukinumab XCT Structural Progression Study
Psoriatic arthritis is related with chronic inflammation and progressive radiographic damages, and it in turn lead to disability and loss in function-ability.
- Trial name
- NCT03623867
- Testing
- Secukinumab
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Spondyloarthritis, Rheumatoid Arthritis
Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis
The primary objective of the study aims to compare the biodiversity of intestinal microbiota between spondylarthritis (SPA) or rheumatoid arthritis (RA) patients and healthy volunteers, by microbiota DNA sequencing in order to…
- Trial name
- MICROBIART (NCT04292067)
- Testing
- Faecal sampling, Blood sampling
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arthritis, Rheumatoid, Spondylarthritis
Immunogenicity and Safety of Vaccinations in Immunocompromised Persons
Backgound and relevance of the project: Patients with autoimmune inflammatory rheumatic diseases (AIIRD) are at increased risk of contracting infections.
- Conditions
- Arthritis, Rheumatoid, Spondylarthritis, Vasculitis
- Trial name
- NCT01947465
- Testing
- Hepatitis A vaccine and tetanus vaccine
- Where
- 10 sites in Switzerland
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism
Autoimmune diseases are the consequence of an abnormality of the immune system, leading it to attack components of our own body. They have a wide variety of presentations.
- Conditions
- Arthritis, Rheumatoid, Spondylitis, Ankylosing, Lupus Erythematosus, Systemic, Scleroderma, Systemic
- Trial name
- MARIGYN (NCT05961267)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 318 people
- Sponsor
- University Hospital, Bordeaux
Inflammatory Disease, Rheumatoid Arthritis
Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism
It is a prospective follow-up. The aim is to study the maintenance of therapeutic at 10 years and 20 years of inflammatory rheumatism (rheumatoid arthritis and spondyloarthritis)
- Conditions
- Inflammatory Disease, Rheumatoid Arthritis, Spondyloarthritis
- Trial name
- PPCRNice (NCT03076866)
- Testing
- observational follow-up:clinical, radiological et biological
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Spondylodiscitis, Spinal Infection
Evaluation of Outcomes of Surgical Treatment for Nonspecific Infectious Spondylodiscitis Via Posterior Approach in One Center.
Non-specific spondylodiscitis is a bacterial infection of the spine that in some cases requires surgical treatment. The basis of surgical treatment is the removal of affected tissues.
- Conditions
- Spondylodiscitis, Spinal Infection, Spondylitis, Discitis
- Trial name
- NCT07349602
- Testing
- Posterior approach to infection site
- Where
- Russia
- Volunteers
- 47 people
- Sponsor
- Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
Rheumatoid Arthritis, Ankylosing Spondylitis
99m-Technetium- Glucosamine in Arthritis
Preliminary data following a pilot study from our institution confirms the ability of 99mTc-glucosamine (99mTc-ECDG) to differentiate between active, subclinical and quiescent disease in patients with rheumatoid arthritis…
- Trial name
- NCT01789151
- Testing
- Technetium labelled glucosamine
- Where
- Australia
- Sponsor
- University of Sydney
Axial Spondylarthritis (axSpA)
Changes in Serum Calprotectin and Their Clinical Correlates in Axial Spondyloarthritis Patients Undergoing Pulmonary Rehabilitation
Our study aims to investigate changes in serum calprotectin levels in patients with axial spondyloarthritis enrolled in a pulmonary rehabilitation programme and to examine the relationship between serum calprotectin levels and…
- Trial name
- NCT07821541
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Giresun University
Spondyloarthritis, Exercise
A Digital Exercise Intervention in Patients With Spondyloarthritis
This protocol describes a 6-month randomised, controlled exercise trial in patients with axial spondyloarthritis (axSpA) with re-randomization after 3-months.
- Trial name
- SPARK (NCT06462937)
- Testing
- Exercise with supervision, Exercise without supervision
- Where
- Norway
- Volunteers
- 260 people
- Sponsor
- Diakonhjemmet Hospital
Rheumatoid Arthritis, Spondyloarthritis
The Norwegian Drug Monitoring Study
Infliximab and other TNF-inhibitors have revolutionised the treatment of several immunological inflammatory diseases. Still, more than half of the patients either do not respond sufficiently to infliximab therapy or loose…
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Ankylosing Spondylitis, Crohn Disease
- Trial name
- NOR-DRUM (NCT03074656)
- Testing
- Therapeutic drug monitoring, Standard care
- Where
- 21 sites in Norway
- Volunteers
- 611 people
- Sponsor
- Diakonhjemmet Hospital
Rheumatoid Arthritis, Psoriatic Arthritis
A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis.
The purpose of this non-interventional study is to evaluate the efficacy of etanercept during routine clinical use over a maximum of 12 months in patients with rheumatoid arthritis (RA), psoriatic arthritis(PsA), axial…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Plaque Psoriasis
- Trial name
- ADEQUATE (NCT02486302)
- Testing
- Etanercept
- Where
- 180 sites in Germany
- Volunteers
- 1,534 people
- Sponsor
- Pfizer
COVID-19, Systemic Lupus Erythematosus
Prevalence and Seroconversion of COVID-19 in Autoimmune Diseases in Europe
The coronavirus disease 2019 (COVID-19) pandemic is a potentially fatal disease that represents a great global public health concern.
- Conditions
- COVID-19, Systemic Lupus Erythematosus, Sjogren's Syndrome, Axial Spondyloarthritis
- Trial name
- Euro-COVIMID (NCT04397237)
- Where
- France
- Volunteers
- 3,100 people
- Sponsor
- Pitié-Salpêtrière Hospital
Rheumatoid Arthritis, Psoriatic Arthritis
INSELMA - a Randomised Controlled Trial
Background: Patients with inflammatory arthritis (IA) experience substantial impact of their disease despite optimal pharmacological treatment.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis
- Trial name
- INSELMA-RCT (NCT06583980)
- Testing
- Interdisciplinary Nurse-coordinated self-management support for people with inflammatory arthritis and substantial disease impact
- Where
- 3 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- The Danish Center for Expertise in Rheumatology
Ankylosing Spondylitis
Open Label Clinical Trial With Rituximab (MabThera ®) in Ankylosing Spondylitis
To evaluate the efficacy and safety of rituximab when added to NSAIDs and/ or methotrexate both for TNFalpha inhibitor naïve or TNFalpha inhibitor failure patients with moderate to severe ankylosing spondylitis
- Trial name
- NCT00432653
- Testing
- rituximab
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Axial Spondyloarthritis
Study of Adalimumab in Patients With Axial Spondyloarthritis
This study will evaluate how well adalimumab works in the short and long term in patients with axial spondyloarthritis who are not diagnosed as having either ankylosing spondylitis or psoriatic arthritis.
- Trial name
- NCT00939003
- Testing
- Adalimumab, Open-label Adalimumab
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 192 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Psoriatic Arthritis
Validation of Handheld Ultrasound Devices in Rheumatology
The goal of this clinical trial is to test the concurrent validity of the Clarius handheld ultrasound devices versus gold-standard device to detect characteristic features of healthy and rheumatic joints in adults Psoriatic…
- Trial name
- NCT06580886
- Testing
- Ultrasound
- Where
- 3 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Systemic Lupus Erythematosus, Arthritic Psoriasis
The Effect of BMS-986165 Combined With an Oral Contraceptive (Ethinyl Estradiol/Norethindrone) in Healthy Female Patients
The purpose of this study is to investigate the effect of BMS-986165 in combination with an oral contraceptive in healthy female patients.
- Conditions
- Systemic Lupus Erythematosus, Arthritic Psoriasis, Psoriasis, Inflammatory Bowel Diseases
- Trial name
- NCT03262727
- Testing
- BMS-986165, Loestrin 1.5/30 (1.5 mg norethindrone acetate/30 μg ethinyl estradiol)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Axial Spondyloarthritis
Tofacitinib in the Treatment of Refractory Axial Spondyloarthritis Patients: A Dose Escalation Study
The goal of this clinical trial is to assess the efficacy of tofacitinib in refractory axial spodyloarthritis (ax-SpA) with dose escalation from 10mg to 15mg.
- Trial name
- NCT06310057
- Testing
- Tofacitinib
- Where
- Bangladesh
- Volunteers
- 92 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
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