Clinical trials: Osteoarthritis
Osteoarthritis
POLARSTEM Cementless Hip Stem
Multicenter observational study to validate that the POLARSTEM™ is a state-of-the-art implant in terms of radiographic, clinical performance and long-term survivorship.
- Trial name
- POLARSTEM (NCT02648152)
- Testing
- Total Hip Arthroplasty
- Where
- 3 sites in Germany, Switzerland
- Volunteers
- 218 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Knee
Calypso Knee System Clinical Study, OUS
A study to evaluate the safety and effectiveness of the Calypso Knee System when used in subjects with symptomatic osteoarthritis of the medial compartment of the knee.
- Trial name
- NCT03838978
- Testing
- Calypso Knee System (Implantable Shock Absorber)
- Where
- 5 sites in Belgium, Poland
- Volunteers
- 81 people
- Sponsor
- Moximed
Pain, Nausea
A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip
The purpose of CLCT-006, a multi-center open-label study, is to evaluate the safety of CL-108 (hydrocodone 7.5 mg/APAP 325 mg, promethazine 12.5 mg) for the treatment of moderate to severe acute pain ("flare") associated with…
- Conditions
- Pain, Nausea, Vomiting
- Trial name
- NCT02462850
- Testing
- CL-108
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Charleston Laboratories, Inc
Chronic Pain, Osteoarthritis
A Confirmatory Study of Fentanyl in Participants With Osteoarthritis or Low Back Pain
The purpose of this study is to evaluate efficacy and safety of fentanyl in opioid-naive participants with osteoarthritis (disorder, which is seen mostly in older persons, in which the joints become painful and stuff) or low back…
- Conditions
- Chronic Pain, Osteoarthritis, Low Back Pain
- Trial name
- NCT01008618
- Testing
- Fentanyl
- Where
- 59 sites in Japan
- Volunteers
- 218 people
- Sponsor
- Janssen Pharmaceutical K.K.
Osteoarthritis, Rheumatoid Arthritis
Observational Study on Non-steroid Anti-inflammatory Drugs (NSAIDs) Treated Patients With Arthritic Disorder
The aim of this study is to find out how patients with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis receiving NSAID-therapy are treated and managed by their doctor in usual clinical practice, how patients…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- EVIDENCE (NCT01176682)
- Where
- 244 sites in Belgium, France and 10 more
- Volunteers
- 1,149 people
- Sponsor
- AstraZeneca
Osteoarthritis
Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.
The Purpose of this trial is to evaluate the use of a cross-over trial design in an osteoarthritis population. We will determine the inter- and intra-subject variability in osteoarthritis (OA) endpoints and evaluate if efficacy…
- Trial name
- NCT00484718
- Testing
- celecoxib, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Pfizer
Osteoarthritis in the Knee
Observational Study of Synovian® Inj. in Patients With Osteoarthritis in the Knee
This is an observational study to evaluate the injection site reactions of Synovian® Inj. in patients with osteoarthritis in the knee
- Trial name
- NCT04369261
- Testing
- Synovian®
- Where
- South Korea
- Volunteers
- 1,949 people
- Sponsor
- LG Chem
Osteoarthritis of the Knee
Study of FX006 in Patients With Osteoarthritis of the Knee
The purpose of this study was to evaluate the safety, efficacy and pharmacokinetics of FX006 in patients with osteoarthritis of the knee.
- Trial name
- NCT01487161
- Testing
- FX006, TCA IR
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 229 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
NANOVAE to Treat Knee Osteoarthritis (KOA)
The below summarizes relevant information for investigator(s) to consider the use of Allogenic Human Amniotic Fluid product in a clinical protocol detailing study design and conduct for a phase I/II randomized, double-blinded…
- Trial name
- NCT06606561
- Testing
- NANOVAE - Acellular Allogenic Human Amniotic Fluid (hAF), 0.9% Sodium Chloride Injection, USP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Nova Vita Laboratory
Osteoarthritis, Knee
Celution Prepared Adipose Derived Regenerative Cells in the Treatment of Osteoarthritis of the Knee
The primary objective of this study is to evaluate the safety and feasibility of intraarticular injection of Celution prepared adipose-derived regenerative cells injected into knees of patients with chronic knee pain due to…
- Trial name
- ACT-OA Knee (NCT02326961)
- Testing
- Celution Device
- Where
- 11 sites in United States
- Volunteers
- 94 people
- Sponsor
- Cytori Therapeutics
Osteoarthritis of the Knee
HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain
Ketoprofen in a topical patch formulation has been demonstrated to be effective for treating mild to moderate pain caused by various musculoskeletal disorders.
- Trial name
- NCT00792727
- Testing
- ketoprofen Patch
- Where
- 36 sites in United States
- Volunteers
- 380 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Osteoarthritis, Osteoarthritis, Knee
A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis
The purpose of this study is to evaluate pain relief, safety, and tolerability of a new treatment (JNJ-42160443) for moderate to severe pain of osteoarthritis of the knee in comparison to a standard pain treatment and placebo.
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Pain, Arthralgia
- Trial name
- NCT01094262
- Testing
- Oxycodone CR (standard pain medication), JNJ-42160443
- Where
- 44 sites in United States, Canada
- Volunteers
- 196 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis (OA) of the Knee
53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee
53-Week Study Evaluating the Safety and Efficacy of Intra-articular (IA) Injections of TPX-100 vs Placebo in Subjects with Mild to Severe Tibio-Femoral Osteoarthritis of the Knee
- Trial name
- NCT06865079
- Testing
- TPX-100 200mg, Once weekly for 4 weeks, PBS
- Where
- 33 sites in United States
- Volunteers
- 270 people
- Sponsor
- OrthoTrophix, Inc
Osteoarthritis, Knee
A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness Scale
Osteoarthritis is a common, chronic, progressive, skeletal, degenerative disorder that frequently affects several joints such as knee, hip, spine and hands.This placebo-controlled clinical trial assessed the effects of naproxen…
- Trial name
- NCT03570554
- Testing
- Naproxen Sodium (Aleve, BAY117031), Acetaminophen ER, Celecoxib
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Bayer
Osteoarthritis
Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain
The purpose of this study is to evaluate the safety and efficacy of a single injection of CNTX-4975 in subjects with chronic, moderate to severe osteoarthritis knee pain.
- Trial name
- NCT02558439
- Testing
- CNTX-4975
- Where
- 22 sites in United States
- Volunteers
- 175 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis
Efficacy and Safety of Diclofenac Sodium Gel in Hand Osteoarthritis
This study will test the efficacy and safety of topical diclofenac sodium gel in the treatment of hand osteoarthritis.
- Trial name
- NCT00171665
- Testing
- Diclofenac topical sodium gel 1%
- Where
- 69 sites in United States
- Volunteers
- 360 people
- Sponsor
- Novartis
Osteoarthritis
Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis
This was a multicenter, randomized, double-blind, placebo-controlled Phase IIb study evaluating intra-articular LNA043 in patients with knee osteoarthritis.
- Trial name
- ONWARDS (NCT04864392)
- Testing
- LNA043
- Where
- 75 sites in United States, Argentina and 13 more
- Volunteers
- 576 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Knee
The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis (EFEX-OA-01)
Aim of EFEX-OA-01: To explore how running, cycling and resting acutely influence levels of collagen and proteoglycan in patients with osteoarthritis knee and in young healthy subjects, as reflected by changes in serum and urine…
- Trial name
- EFEX-OA-01 (NCT04542655)
- Testing
- Ergometer Cycling followed by treadmill running, Treadmill Running followed by ergometer cycling, Rest
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nordic Bioscience A/S
Osteoarthritis, Knee
Persona TKA With iASSIST Knee System and iASSIST Knee System
The purpose of this study is to compare the accuracy of knee component alignment between patients operated with iASSIST Knee (Investigational group) versus patients operated without iASSIST Knee (Control group) using the same…
- Trial name
- NCT03227692
- Testing
- Persona Knee System, Total Knee Arthroplasty, iAssist Knee
- Where
- 3 sites in Japan
- Volunteers
- 93 people
- Sponsor
- Zimmer Biomet
Osteoarthritis of Knee, Osteoarthritis, Knee
A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, 6-week trial of a formulation of AMZ001 once daily versus placebo once daily.
- Trial name
- AMZ001 (NCT06693648)
- Testing
- AMZ001 Diclofenac gel
- Where
- 11 sites in United States, China and 3 more
- Volunteers
- 549 people
- Sponsor
- Amzell
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