Clinical trials: Osteoarthritis (OA)
Knee Osteoarthritis
Trial to Evaluate Efficacy and Safety of Combination of Diacerein and Celecoxib Administered in Patients With Knee OA
The purpose of this study is to evaluate the pain relief effect of Co-administration of Diacerein with Celecoxib in patients with knee osteoarthritis compared with single administration of each drug.
- Trial name
- DIA IIT_01 (NCT03404479)
- Testing
- Diacerein, Celecoxib
- Where
- 2 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Whan-Seok Choi
Osteoarthritis, Osteoarthritis (OA) of the Knee
Feasibility of Choose to Move Replacement Ready
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada.
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis, Hip, Total Knee Arthroplasty; Total Hip Arthroplasty
- Trial name
- CTM-RR (NCT07069179)
- Testing
- Choose to Move Replacement Ready
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Osteoarthritis
Etoricoxib vs. Diclofenac in OA (0663-805)(COMPLETED)
To compare the safety and tolerability of etoricoxib and diclofenac sodium in the treatment of osteoarthritis of the knee or hip during a six week period.
- Trial name
- NCT00542087
- Testing
- MK0663, etoricoxib / Duration of Treatment: 6 Weeks, Comparator: diclofenac sodium / Duration of Treatment: 6 Weeks
- Volunteers
- 516 people
- Sponsor
- Organon and Co
Osteoarthritis
Efficacy and Safety of Cortex Eucommiae (CE: Eucommia Ulmoides Oliver Extract) in Subjects With Mild Osteoarthritis
The purpose of this clinical trial is to evaluate the efficacy and safety of Cortex Eucommiae (CE: Eucommia ulmoides Oliver extract) in subjects with mild osteoarthritis (OA).
- Trial name
- NCT03744611
- Testing
- CE
- Where
- 3 sites in South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jaseng Medical Foundation
Knee Osteoarthritis, Knee Pain Chronic
Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients
The present prospective trial is designed to evaluate the efficacy of CyMedica Orthopedics e-vive™ system, a multifunctional electrotherapy device providing neuromuscular electrical stimulation (NMES) for reducing pain and…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NMES (NCT03980964)
- Testing
- Active NMES
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CyMedica Orthopedics, Inc
Knee Osteoarthritis (Knee OA), OA
Kinesiophobia and Its Impact on Pain and Function in Knee Osteoarthritis
Knee osteoarthritis (OA) is the most common chronic joint disorder, especially in older adults, and is a leading cause of pain, disability, and reduced quality of life.
- Conditions
- Knee Osteoarthritis (Knee OA), OA, Kinesiophobia
- Trial name
- KinesiOA (NCT07161895)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara Training and Research Hospital
Knee Osteoarthritis (Knee OA)
Knee OsteoArthritis Long-term Assessment
The goal of this clinical study is to learn if Hydrogel OA 2% injection is safe and whether it works to improve symptoms of diagnosed knee osteoarthritis in adults when compared to Hyaluronic Acid (Durolane), a treatment that is…
- Trial name
- KOALA (NCT06839222)
- Testing
- Hydrogel OA 2%, Hyaluronic Acid (Durolane)
- Where
- 5 sites in Belgium
- Sponsor
- Allegro NV/SA
Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty
GENicular Nerve Block in KNEE Arthroplasty
The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis (OA) of the Knee, Total Knee Arthroplasty, Genicular Nerve Block
- Trial name
- GENKNEE (NCT07589127)
- Testing
- Preoperative genicular nerve block (GNB)
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Helse Møre og Romsdal HF
Knee Osteoarthristis
Feasibility of a Self-management App for People With Knee Osteoarthritis (OA-AID Feasibility Study)
In this feasibility trial, an 8-week digital intervention including remote monitoring in patients with knee osteoarthritis (OA) will be tested.
- Trial name
- NCT06656845
- Testing
- Genus, a self-management app for patients with knee osteoarthritis
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Diakonhjemmet Hospital
Osteoarthritis (OA) of the Knee
Total Osteo-Cartilage Replacement for the Treatment of Osteoarthritis of Knee
Young patients who require total knee arthroplasty with metallic and plastic implants will undergo femoral condyle cartilage and top of the tibia with meniscus replacement.
- Trial name
- NCT07769632
- Testing
- Total osteo-cartilage replacement of the distal femur and proximal tibia, including medial and lateral meniscus., allogenic bone and cartilage graft
- Where
- Bahrain
- Volunteers
- 10 people
- Sponsor
- AlSalam Hospital
Knee OA
a Single HYAJOINT Plus Combined With a Single PPR Versus a Single PRP for Knee OA
Intraarticular hyaluronan or platelet-rich plasma (PRP) is each effective in the treatment for knee osteoarthritis (OA). The efficacy of combined hyaluronan with PRP for knee OA remained unclear.
- Trial name
- NCT04315103
- Testing
- a single intraarticular injection of HYAJOINT Plus (3 ml) followed by 3 ml PRP
- Where
- 2 sites in Taiwan
- Volunteers
- 85 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Erosive Osteo-Arthritis
Study to Evaluate the Efficacy of Adalimumab in Patients With Erosive Osteoarthritis of the Interphalangeal Finger Joints
Patients will be randomized into two groups (1/1) during one year: 40 mg adalimumab subcutaneously (sc) every other week placebo The effect on x-rays and clinical parameters will be evaluated.
- Trial name
- NCT00296894
- Testing
- Adalimumab (40 mg sc every other week)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Ghent
Pain
A Study to Characterize Diclofenac's Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty
The purpose of this study is to evaluate the exposure of diclofenac in the plasma and in the knee joint following topical administration of DDEA gel 4 gram (g) applied twice daily for 7 days.
- Trial name
- NCT03497039
- Testing
- Diclofenac Diethylamine (DDEA) gel
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Knee Osteoarthritis
High-speed Power Training in Older Adults With Knee Osteoarthritis (OA)
We are exploring a unique weight-training program for men and women 55 years or older with knee osteoarthritis (OA) that emphasizes high-speed movements.
- Trial name
- NCT01328340
- Testing
- High-speed power training, Slow-speed strength training
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Knee Osteoarthritis (Knee OA)
Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis
Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability among Veterans, which contributes significantly to reduced mobility, impaired quality of life, and increased health care utilization.
- Trial name
- NCT07481474
- Testing
- Atibuclimab
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Chronic Pain, Osteoarthritis
Predicting Successful Outcome of Interdisciplinary Biopsychosocial Rehabilitation in Osteoarthritis
The goal of this prospective study is to identify variables that can predict whether an interdisciplinary biopsychosocial intervention for patients with osteoarthritis will be successful.
- Conditions
- Chronic Pain, Osteoarthritis, Disability Physical
- Trial name
- CIR-predict (NCT05661760)
- Testing
- interdisciplinary multimodal pain treatment
- Where
- Netherlands
- Volunteers
- 2,309 people
- Sponsor
- Maastricht University
Osteoarthritis, Knee
Efficacy and Safety of G001 in Patients With Osteoarthritis (OA) of the Knee
Phase 2 multicenter, double-blind, randomized, parallel-group, vehicle-controlled study to evaluate the efficacy, safety, and local tolerability of G001 topical gel compared to matching Vehicle topical gel in patients with…
- Trial name
- NCT05007808
- Testing
- G001 Topical Gel, Vehicle
- Where
- 10 sites in Canada
- Volunteers
- 210 people
- Sponsor
- BUZZZ Pharmaceuticals Limited
Osteoarthritis, Knee Osteoarthritis
Impact of Different Exercise Programs on Knee OA
This study will examine and compare the changes in serum biomarkers, joint kinematics, and thigh muscle strength based on three different 8-week exercise protocols in individuals with knee pathology: Lower-body positive-pressure…
- Conditions
- Osteoarthritis, Knee Osteoarthritis, Arthritis, Joint Diseases
- Trial name
- NCT05844124
- Testing
- Exercise for Knee Osteoarthritis Recommendations (Control group), Exercise for Knee Osteoarthritis -(LBPP supported low-load treadmill Walking), Exercise for Knee Osteoarthritis - (Aquatic Walking)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shirley Ryan AbilityLab
Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)
The goal of this clinical trial is to see if people with knee osteoarthritis would be willing to comply and adhere to incorporating Recombinant Human Growth Hormone (rHGH), specifically Saizen Somatropin solution, into their…
- Trial name
- KORR (NCT07036003)
- Testing
- Somatropin (recombinant human growth hormone)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Dr. David Wasserstein
Knee Osteoarthritis
A Powered Exoskeleton for Veterans With Knee OA
The purpose of this study is to evaluate in-laboratory mobility outcomes, pain perception, and user satisfaction with the Keeogo , a robotic exoskeleton for providing assistance on knees during stand and swing for a population…
- Trial name
- NCT04653896
- Testing
- Keeogo
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development