Clinical trials: Osteoarthritis (OA)
Osteoarthritis, Knee
An Exploratory Clinical Study to Investigate the Effect of autoSTEM-OA and alloSTEM-OA in Participants With Knee Osteoarthritis
A phase 1 exploratory clinical study to investigate safety, tolerance and efficacy of a single intra-articular injection of autoSTEM-OA or alloSTEM-OA in participants with mild to moderate knee osteoarthritis
- Trial name
- NCT05789719
- Testing
- STEM-OA
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- StemMedical A/S
Osteoarthritis, Knee
A First-in-Human Study of XSTEM-OA in Patients With Knee Osteoarthritis
The aim of the study is to assess safety, tolerability and preliminary efficacy of XSTEM-OA when administered as a single intra-articular injection to patients with symptomatic knee osteoarthritis.
- Trial name
- NCT05344157
- Testing
- XSTEM-OA
- Where
- 2 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Xindu Pty Ltd
Pain
Fentanyl Transdermal Matrix Patch ZR-02-01 to Treat Chronic, Moderate to Severe Osteoarthritis (OA) Pain
The purpose of this study is to evaluate the effectiveness of the Matrix Fentanyl Patch ZR-02-01 in providing pain relief.
- Trial name
- NCT00108771
- Testing
- ZR-02-01 Fentanyl Transdermal Matrix Patch
- Where
- 13 sites in United States
- Volunteers
- 202 people
- Sponsor
- ZARS Pharma Inc.
Osteo Arthritis of the Knee
Hydrogel Assessment for Local Treatment of Osteoarthritis
The study aims to evaluate the safety and tolerability of one intra-articular injection of Hydrogel OA 2% for the symptomatic treatment of osteoarthritis of the knee.
- Trial name
- HALO (NCT07516457)
- Testing
- Injection of Hydrogel OA 2%
- Where
- 3 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Allegro NV/SA
Knee Osteoarthritis (OA)
Effects of Core Stabilization Exercises Versus Foot-Ankle Strengthening Program in Patients With Knee Osteoarthritis.
Knee osteoarthritis (OA) is also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage. It is most common in the elder population.
- Trial name
- NCT06658249
- Testing
- Core Stabilization Exercises with Foot-Ankle Strengthening Program, Foot-Ankle Strengthening Program
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Osteoarthritis of the Knee
Hydros Joint Therapy and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis (OA)
The purpose of this study is to evaluate the safety and performance of Hydros Joint Therapy (Hydros) and Hydros-TA Joint Therapy (Hydros-TA) for treatment of pain from osteoarthritis of the knee, in patients who have failed to…
- Trial name
- NCT01134406
- Testing
- Hydros Joint Therapy, Hydros-TA Joint Therapy, Synvisc-One
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- Carbylan Therapeutics, Inc.
Osteoarthitis, Osteoarthritic Knee Pain
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee.
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- Medial OA CSI (NCT07804446)
- Testing
- Anteromedial Injection, Anterolateral Injection
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Chicago
Osteoarthritis Hand
Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of PIP Joint Osteoarthritis
The aim of this open, prospective, multicenter trial is to evaluate the use of a sterile, devitalized, processed umbilical cord amniotic membrane implant placed in joint interposition in the treatment of PIP joint osteoarthritis.
- Trial name
- NCT06034262
- Testing
- SclerFIX-IP
- Where
- 3 sites in France
- Volunteers
- 1 people
- Sponsor
- TBF Genie Tissulaire
Osteoarthritis (OA) of the Hip
Gait After THA: Direct Anterior vs Manual Posterior vs Robotic Posterior
The purpose of this study is to evaluate the gait biomechanics following THA on 3 groups of subjects undergoing DAA (manual) and PA (manual and robotic) surgical approaches.
- Trial name
- NCT07226973
- Testing
- Total hip arthroplasty via direct anterior approach (manual, non-robotic), Total hip arthroplasty via posterior approach (manual, non-robotic), Robotic-assisted total hip arthroplasty via posterior approach
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Ochsner Health System
Arthritis, Arthritis (Knee)
Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic and Caliper-based Techniques
Knee replacement surgery is a surgery designed to treat severe arthritis of the knee. However, as many as 20% of patients are not satisfied with the results of their surgery.
- Conditions
- Arthritis, Arthritis (Knee), Osteoarthritis, Osteoarthritis Knee Pain
- Trial name
- NCT06709703
- Testing
- Kinematic aligned total knee replacement
- Volunteers
- 200 people
- Sponsor
- Université de Sherbrooke
Osteoarthritis (OA) of the Knee
The Effects of Functional Electrical Stimulation (FES) and Exercise on the Quadriceps in Patients With Knee Osteoarthritis
In our study, we aimed to compare the effects of functional electrical stimulation (FES) and an exercise program on quadriceps muscle strength and structural characteristics, as well as their impact on gait analysis, pain…
- Trial name
- NCT07309003
- Testing
- functional electrical stimulation (FES)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, Shoulder
TSA Techniques in Glenohumeral OA
Osteoarthritis (OA) of the shoulder is a disease resulting from the wearing down of cartilage over time. OA can produce pain and dysfunction at the affected joint and is a growing occurrence in an aging population.
- Trial name
- NCT02966886
- Testing
- Eccentric Reaming, Augmented Glenoid Component Implantation, Posterior Glenoid Bone Grafting
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis
Weight-Bearing Magnetic Resonance Imaging (MRI) for Analysis of Knee Osteoarthritis (OA)
The purpose of the study is to use different x-ray and magnetic resonance (MR) imaging techniques to take pictures of the knee. There are two specific purposes to the study: 1.
- Trial name
- NCT00665548
- Testing
- X-ray; magnetic resonance imaging
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pain
Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Osteoarthritis (OA) of the Knee
The primary aim of this study is to investigate if AZD1386 is efficacious as an analgesic in patients with osteoarthritis of the knee and at what dose.
- Trial name
- OA19 (NCT00878501)
- Testing
- AZD1386
- Where
- 41 sites in Bulgaria, Canada and 5 more
- Volunteers
- 241 people
- Sponsor
- AstraZeneca
Osteoarthritis
Surgery Versus no Surgery for OA of the Knee
The purpose of this trial is to evaluate the effectiveness of arthroscopy (lavage and debridement) in conjunction with the best available non-surgical treatment versus the best available non-surgical treatment alone (medication…
- Trial name
- NCT00158431
- Testing
- Arthroscopy plus Medical Management, Medical Management
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- Fowler Kennedy Sport Medicine Clinic
Osteoarthritis of the Knee or Hip
Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip
The primary objective of the study is to describe the safety and tolerability of fasinumab, including adverse events of special interest (AESIs), in patients with pain due to radiographically-confirmed OA of the knee or hip.
- Trial name
- FACT LTS & OA (NCT02683239)
- Testing
- Fasinumab
- Where
- 149 sites in United States, Bulgaria and 19 more
- Volunteers
- 5,331 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis, Knee
Intra-articular Injection of MSC-derived Exosomes in Knee Osteoarthritis (ExoOA-1)
The study aim to evaluate safety of exosomes (sEVs) from allogeneic mesenchymal stromal cells delivered by an intra-articular injection in the knee of patients with mild to moderate symptomatic osteoarthritis.
- Trial name
- ExoOA-1 (NCT05060107)
- Testing
- Exosomes (sEVs)
- Volunteers
- 10 people
- Sponsor
- Francisco Espinoza
Osteoarthritis
26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle
26 week open label study of treatment with Durolane for OA pain of the ankle
- Trial name
- NCT02627859
- Testing
- Durolane SJ
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Bioventus LLC
Osteoarthritis, Knee
Safety of Intra-Articular Sc-rAAV2.5IL-1Ra in Subjects With Moderate Knee OA
This study seeks to determine the safety of three different doses of sc-rAAV2.5IL-1Ra delivered by intra-articular injection into one knee joint of patients with moderate OA of the knee.
- Trial name
- AAVIL-1Ra (NCT02790723)
- Testing
- sc-rAAV2.5IL-1Ra
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Osteoarthritis (OA)
Effect of Chair Yoga on Elders With Osteoarthritis
The current study is a two-arm randomized controlled clinical trial to test the feasibility of recruiting, randomizing, and having older adults with osteoarthritis (OA) adhere to and safely complete the 8-week Sit 'N' Fit Chair…
- Trial name
- NCT02113410
- Testing
- Sit 'N' Fit Chair Yoga (SNFCY), Health Education Program (HEP)
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Florida Atlantic University