Clinical trials: Osteoarthritis (OA)
Osteoarthritis, Pain
Study of Efficacy, Safety of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3001
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as adjunctive therapy compared with placebo in participants with chronic moderate to severe pain and functional impairment from knee…
- Trial name
- NCT02336685
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg, Opioid
- Where
- 53 sites in United States, Canada and 4 more
- Volunteers
- 79 people
- Sponsor
- Janssen Research & Development, LLC
Osteo Arthritis Knee
A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the analgesic efficacy of V120083 twice daily compared to placebo in subjects with moderate to severe chronic pain due to OA of the knee.
- Trial name
- NCT03028870
- Testing
- V120083, Naproxen
- Where
- 30 sites in United States
- Volunteers
- 291 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis, Knee
Safety and Efficacy of RHH646 for Knee Osteoarthritis
The purpose of this study was to evaluate the articular cartilage-regenerating capacity of RHH646 in the knee as well as to assess safety and tolerability in participants with knee osteoarthritis.
- Trial name
- NCT05816395
- Testing
- RHH646
- Where
- 10 sites in United States, Argentina and 3 more
- Volunteers
- 82 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis
Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP) (R33)
The purpose of this study is to test an osteoarthritis (OA) primary care Physical activity Care Pathway (OA-PCP), a scalable intervention that includes: 1) a practical process for physical inactivity screening in primary care, 2)…
- Trial name
- OA-PCP (NCT04533711)
- Testing
- OA-PCP Intervention, Attention Control
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis of the Knee
Dose Finding Study of Bone Morphogenetic Protein 7 (BMP-7) in Subjects With Osteoarthritis (OA) of the Knee
The objectives of the study are to evaluate the safety and efficacy of intraarticular BMP-7 for the treatment of osteoarthritis of the knee.
- Trial name
- NCT01111045
- Testing
- Bone morphogenetic protein 7
- Where
- 25 sites in United States
- Volunteers
- 355 people
- Sponsor
- Stryker Biotech
Osteoarthritis (OA) of the Knee, Fracture
LinkSymphoKnee (LSK) Total Knee Replacement System Study - Ultra-congruent (UC)
To collect information about implant performance and patient clinical outcomes in patients undergoing primary total knee arthroplasty with the LinkSymphoKnee total knee replacement system with ultra-congruent tibial bearing…
- Conditions
- Osteoarthritis (OA) of the Knee, Fracture, Rheumatoid Arthritis
- Trial name
- NCT06670651
- Testing
- total knee arthroplasty device
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- LinkBio Corp.
Knee Osteoarthritis
Dietary Supplementation With Blueberry in OA
Osteoarthritis is a painful long term joint condition that is associated with poor quality of life. There are no treatments to prevent it. Inflammation is one cause of osteoarthritis. This inflammation is complex.
- Trial name
- NCT05784545
- Testing
- Blueberry powder supplement, Maltodextrin supplementation
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University of Exeter
Knee Osteoarthritis, Obese
GetHealthy-OA: A Program to Improve Pain and Function for Patients With Knee Osteoarthritis, Obesity, and Depression
The investigators have previously identified knee osteoarthritis patients with the combination of depression and an unhealthy weight may be an increased risk of more rapid joint degeneration and worsening pain.
- Conditions
- Knee Osteoarthritis, Obese, Depression
- Trial name
- NCT05482672
- Testing
- Fisetin, GetHealthy-OA mind-body program, Health education booklet
- Where
- 2 sites in United States
- Sponsor
- Cale Andrew Jacobs, PhD
Knee Osteoarthritis
Effectiveness of Cane in Osteoarthritis (OA) Patients
Sixty four participants were enrolled in a randomized, controlled clinical trial to evaluate the effectiveness of daily cane use on pain, function, quality of life and energy consumption during the gait in patients with knee…
- Trial name
- NCT00698412
- Testing
- Cane
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis (OA) of the Knee
The Effects of Functional Electrical Stimulation (FES) and Exercise on the Quadriceps in Patients With Knee Osteoarthritis
In our study, we aimed to compare the effects of functional electrical stimulation (FES) and an exercise program on quadriceps muscle strength and structural characteristics, as well as their impact on gait analysis, pain…
- Trial name
- NCT07309003
- Testing
- functional electrical stimulation (FES)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis
Effects of Synvisc on Cartilage in Knee Osteoarthritis (OA)
Hylan G-F 20 (Synvisc) is an FDA-approved hyaluronate derivative used to treat knee osteoarthritis (OA). Animal studies have shown that Synvisc can have favorable effects on cartilage when injected into joints.
- Trial name
- NCT00949494
- Testing
- Synvisc
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Endeavor Health
Osteoarthritis
Autologous Conditioned Plasma (ACP) Intra-articular (IA) Injections for Knee Osteoarthritis (OA)
This study is primarily investigating the effectiveness of Autologous Conditioned Plasma (ACP) Intra-articular (IA) in patients with Osteoarthritis (OA) in the knee.
- Trial name
- NCT02713542
- Testing
- ACP
- Where
- 4 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Arthrex, Inc.
Osteoarthritis
Effect of Structured Info and Adapted Exercise in OA
Physical activity level is measured at baseline and after 3 and 12 months after structured information and individually adapted exercise for patients with osteoarthritis in hip or knee.
- Trial name
- NCT02022566
- Testing
- A supported self management of osteoarthritis program
- Where
- Sweden
- Volunteers
- 317 people
- Sponsor
- Lund University
Total Knee Arthroplasty, Knee Osteoarthritis (OA)
The Medially Pedicled IPFP flap in TKA
This is a single-center prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before total knee arthroplasty (TKA).
- Trial name
- NCT06704776
- Testing
- "The medially pedicled IPFP flap" group, "Complete IPFP removal" group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Osteoarthritis
Broccoli In Osteoarthritis
To determine whether dietary sulforaphane (SFN), naturally available from eating broccoli, improves pain in people with knee osteoarthritis (OA), the trial will compare broccoli soup (rich in SFN) with a soup, which does not…
- Trial name
- BRIO (NCT03878368)
- Testing
- Sulforaphane
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Osteoarthritis, Hip
Changes in Postural Stability Following THA for OA
Total hip arthroplasty (THA) is a common surgery that eases pain, restores functional movement, and improves the overall quality of life in people with severe hip osteoarthritis (OA).
- Trial name
- CPS (NCT06088160)
- Testing
- Total Hip Arthroplasty
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Western University, Canada
Osteoarthritis, Osteo Arthritis Knee
Exercise on Knee OA With the Star Excursion Balance Test
Osteoarthritis is a prevalent and disabling condition. Exercise is recommended to maintain strength and mobility, and to decrease pain.
- Trial name
- NCT03450486
- Testing
- exercise
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Western University, Canada
Osteoarthritis
A Longitudinal Study of Osteoarthritis (OA) Disease Progression Measured by MRI, dGEMRIC, and Radiography
In order to design future disease modifying osteoarthritis drug (DMOAD) proof of concept studies, this study is being conducted to assess magnetic resonance imaging (MRI) measurements of cartilage morphology and glycosaminoglycan…
- Trial name
- NCT00505297
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hand Osteoarthritis
The Hand Osteoarthritis Exercise Trial
The purpose of this study is to evaluate the effect of a hand exercise intervention on function and osteoarthritis symptoms in persons with hand osteoarthritis .
- Trial name
- NCT01245842
- Testing
- Hand exercise program
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- Diakonhjemmet Hospital
Osteoarthritis of the Knee
Shengyu Decoction and Lijin Manipulation for Knee OA: 3D Gait Analysis
Detailed Description Avoid duplicating information that will be entered or uploaded elsewhere in the record.
- Trial name
- NCT06451783
- Testing
- Traditional Chinese medicine combined with manipulation treatment, Celecoxib capsule
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Xuhui Central Hospital, Shanghai