Clinical trials: Osteoarthritis Ankle
Degenerative Joint Disease of the Ankle
A Pilot Study to Evaluate the Contribution of the Saphenous Nerve in Ankle Pain of Patients With Degenerative Joint Disease of the Ankle
To assess the pain scores before and after saphenous nerve block placement in patients with degenerative joint disease of the ankle
- Trial name
- NCT01716650
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Ankle Osteoarthritis
Cryoneurolysis for Improvements in Pain, ADL and QOL in Patients With Ankle Osteoarthritis
This will be an open-label trial to describe the effects of cryoneurolysis with iovera° on symptom relief in patients with painful Kellgren-Lawrence (KL) grade 2-4 ankle osteoarthritis (OA).
- Trial name
- NCT03567187
- Testing
- iovera
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Post-traumatic; Arthrosis, Tibial Fractures
Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?
High-energy tibial pilon fractures have historically been associated with poor outcomes largely due to the elevated risk of severe post-traumatic arthritis.
- Conditions
- Post-traumatic; Arthrosis, Tibial Fractures, Post-Traumatic Osteoarthritis of Ankle
- Trial name
- NCT05652881
- Testing
- Joint Lavage
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Ankle Osteoarthritis, Ankle - Recurrent Dislocation
Early MOtion Total Ankle Artroplasty
Evaluate the clinical and radiographic results of patients undergoing total ankle arthroplasty and treated in the post-operative period in a randomized manner with early mobilization of the ankle joint or with cast immobilization…
- Conditions
- Ankle Osteoarthritis, Ankle - Recurrent Dislocation, Cartilage Disease, Ankle Arthropathy
- Trial name
- EMOTAA (NCT06525545)
- Testing
- early mobilizzation of the ankle
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Istituto Ortopedico Rizzoli
Ankle Osteoarthritis
Gait Analysis Following Total Ankle Replacement and Subtalar Fusion
Subtalar fusion is commonly performed in post-traumatic subtalar osteoarthritis, rheumatoid arthritis, posterior tibial tendon dysfunction, tarsal coalition and primary subtalar osteoarthritis.
- Trial name
- NCT03356951
- Testing
- TAR through anterior approach and subtalar fusion, TAR through lateral approach and subtalar fusion
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Rheumatoid Arthritis, Degenerative Arthritis
Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)
A post market, prospective, non-randomized, multi-center, open-label,clinical study using survivorship as the reference performance goal to study the safety and efficacy of the Cadence Total Ankle System (TAS) when used for…
- Conditions
- Rheumatoid Arthritis, Degenerative Arthritis, Post Traumatic Arthritis
- Trial name
- Cadence (NCT03142958)
- Testing
- Integra Cadence Total Ankle System
- Where
- 11 sites in United States, Canada
- Volunteers
- 132 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis of Multiple Joints of Ankle or Foot, Healthy
Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function
Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy…
- Trial name
- OPIOVASC (NCT03781544)
- Testing
- Tramadol, Paracetamol, Diclofenac
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Ankle Fractures, Post-traumatic Osteoarthritis
Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. Research suggests that ankle arthritis develops after ankle fracture, in part, due to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP-FPA2 (NCT04562896)
- Testing
- Custom Carbon Fiber Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteoarthritis Ankle, Post-Traumatic Osteoarthritis of Ankle
Post Approval Study2: Hintermann Series H3 Total Ankle Replacement System
The H3 TAR Prosthesis was approved by FDA (P160036) on June 4, 2019. Continued approval of the premarket approval application (PMA) is contingent upon the submission of periodic reports (Annual Report), required under 21 CFR…
- Conditions
- Osteoarthritis Ankle, Post-Traumatic Osteoarthritis of Ankle, Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
- Trial name
- NCT04770870
- Testing
- Hintermann Series H3 Total Ankle Replacement System
- Where
- 11 sites in United States
- Volunteers
- 94 people
- Sponsor
- DT MedTech, LLC
Osteoarthritis
Efficacy of 3 Weekly Injections of Hyaluronate in Patients With Ankle Osteoarthritis
The aim of this study was to investigate the efficacy and safety of three weekly intraarticular injections of Hyaluronate (HA) in patients with unilateral ankle Osteoarthritis (OA).
- Trial name
- NCT00918736
- Testing
- sodium hyaluronate
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Ankle Sprains
Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation
The purpose of this project is to compare a novel sensorimotor ankle rehabilitation training (SMART) protocol for Lateral ankle sprains (LASs) against a standard of care (SOC) protocol to determine if it is more successful at…
- Trial name
- NCT03663361
- Testing
- SMART Intervention, Standard of Care Intervention
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Phillip Gribble
Ankle Osteoarthritis
Prospective Randomized Evaluation of a Two and Three Piece Total Ankle Replacement
This is a randomized study to prospectively compare and evaluate the functional outcome and patient satisfaction of total ankle replacements for tibio-talar osteoarthritis using either the STAR or Salto-Talaris prothesis.
- Trial name
- NCT01504438
- Testing
- Salto-Talaris Total Ankle Replacement, STAR Total Ankle Replacement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Ankle Fractures, Intra-Articular Fractures
Prevention of Posttraumatic Osteoarthritis After Acute Intraarticular Fractures
Intra-articular fracture is a very common fracture. The only method to treat these fractures is surgery with plate and screws followed by rehabilitation.
- Conditions
- Ankle Fractures, Intra-Articular Fractures, Osteoarthritis
- Trial name
- NCT03769909
- Where
- Denmark
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Post Traumatic Arthritis, Osteoarthritis
A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System
The goal of this study is to demonstrate the safety and performance of the Incompass™ Total Ankle System after surgery over the standard follow-up period.
- Conditions
- Post Traumatic Arthritis, Osteoarthritis, Total Ankle Replacement, Total Ankle Prosthesis
- Trial name
- NCT07118501
- Testing
- Total Ankle Replacement
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Stryker Trauma and Extremities
Arthritis, Rheumatoid, Post-traumatic Osteoarthritis
UK Infinity, Post-Market Clinical Follow-up Study
Study Title UK Post-Market Clinical Follow-Up Of The INFINITY® Total Ankle System Study Design Prospective, multi-site, multi-year post-market clinical follow-up study Study Group Primary/Unilateral and/or bilateral Total Ankle…
- Conditions
- Arthritis, Rheumatoid, Post-traumatic Osteoarthritis, Degenerative Arthritis
- Trial name
- NCT03063593
- Where
- 12 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Stryker Trauma and Extremities
Osteoarthritis of Multiple Joints of Ankle or Foot
Agili-CTM Implant Performance Evaluation in the Treatment of Osteoarthritis of the Great Toe
The purpose of this study is to evaluate the performance of the Agili-CTM implant in the treatment of osteoarthritis of the Great Toe.
- Trial name
- NCT02831244
- Testing
- Agili-CTM
- Where
- 4 sites in Israel, Italy and 2 more
- Volunteers
- 20 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis
26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle
26 week open label study of treatment with Durolane for OA pain of the ankle
- Trial name
- NCT02627859
- Testing
- Durolane SJ
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Bioventus LLC
Primary Arthrosis, Post Traumatic Arthritis
2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use
This post-approval study is being conducted to examine the performance of the STAR Ankle under actual conditions of use.
- Conditions
- Primary Arthrosis, Post Traumatic Arthritis, Rheumatoid Arthritis, Osteoarthritis
- Trial name
- STAR 2 PAS (NCT01284283)
- Testing
- Scandinavian Total Ankle Replacement System (STAR Ankle)
- Where
- 9 sites in United States
- Volunteers
- 102 people
- Sponsor
- Encore Medical, L.P.
Ankle Osteoarthritis, Post-Traumatic Osteoarthritis of Ankle
Post- Approval Hintermann Series H® Study 1
The H3 TAR device received U.S. Food and Drug Administration (FDA) Premarket Approval (PMA) on June 4, 2019, and as a condition of that approval, this study is being conducted to provide long-term safety and effectiveness of the…
- Conditions
- Ankle Osteoarthritis, Post-Traumatic Osteoarthritis of Ankle, Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
- Trial name
- NCT06514196
- Testing
- Hintermann Series H3 Total Ankle Replacement System
- Where
- Switzerland
- Volunteers
- 298 people
- Sponsor
- DT MedTech, LLC
Osteochondritis Dissecans
Prospective 2-year Data Collection of the First 10 Patients After Ankle Spacer Implantation
Osteochondral defects (OCD) of the talus are pathologic lesions of the talar cartilage and its subchondral bone and might severely deteriorate the quality of life.
- Trial name
- NCT04297449
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Hannover Medical School