Clinical trials: Osteoarthritis Knee Pain
Chronic Knee Pain
Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO)
This study aims to determine analgesic and anti-inflammatory effects of dual-wavelength PBM in people with symptomatic knee OA.
- Trial name
- EPIC-KO (NCT07079969)
- Testing
- Photobiomodulation therapy (PBM) device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Knee Osteoarthritis
Effectiveness of Ultrasound Guided Adductor Canal Block on Chronic Pain in Knee Osteoarthritis
Adductor canal block has become popular as effective mean for pain relief following knee surgery.This block has not been checked in chronic pain patients.The purpose of this study is to assess the efficacy and safety of adductor…
- Trial name
- NCT02695654
- Testing
- Levobupivacaine, Clonidine
- Where
- Slovenia
- Volunteers
- 77 people
- Sponsor
- Mensur Salihovic
Hyperglycemia, Hypercholesterolemia
Glucose Metabolism Disorders and Metabolic Syndrome Before and After Primary Hip and Knee Replacement
Osteoarthritis patients undergoing primary hip and knee replacement are followed-up and changes in their glucose metabolism and other metabolic parameters (obesity, cholesterol levels) are examined.
- Conditions
- Hyperglycemia, Hypercholesterolemia, Persistent Postoperative Pain, Hip Replacement
- Trial name
- HyTe-2 (NCT01743313)
- Where
- Finland
- Volunteers
- 155 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Osteoarthritis, Knee
Efficacy and Safety of Single, Low-dose Dexamethasone in Patients After Total Knee Arthroplasty
This study was conducted to determine the efficacy of an additional preemptive, single, low-dose dexamethasone in terms of incidence and severity of postoperative nausea/vomiting (PONV), pain level, and the safety in terms of…
- Trial name
- NCT01612702
- Testing
- Dexamethasone
- Where
- South Korea
- Volunteers
- 291 people
- Sponsor
- Tae Kyun Kim
Knee Osteoarthritis
The Effect of Elastic Bandage Compression on Pain and Function in Individuals With Knee Osteoarthritis
Introduction and Purpose: Compression is a tactile stimulus that can reduce the perception of pain by stimulating tactile skin receptors and the speed of nerve conduction.
- Trial name
- NCT04724902
- Testing
- Elastic bandage compression
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Universidade Federal de Sao Carlos
Knee Osteoarthritis, Knee Pain Chronic
The Effect of PEMF for Patients With Knee OA
Health care costs are increasing alarmingly, which will impose an overwhelming economic burden to an aging society like that of Hong Kong.
- Trial name
- NCT05548712
- Testing
- Pulse Electromagnetic Field
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis
An Investigation of ReNu™ Knee Injection in Patients With Osteoarthritis
This is a Prospective, Randomized study evaluating the efficacy of ReNu for the treatment of Kellgren-Lawrence grade 2 or 3 osteoarthritis.
- Trial name
- NCT02318511
- Testing
- Knee injection, ReNu amniotic allograft, Hyaluronic Acid
- Where
- 12 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NuTech Medical, Inc
Osteoarthritis of the Knee
Measures of Pain Relevant to Knee Osteoarthritis
The aim is to improve understanding of the assessment of pain experience in patients with osteoarthritis (OA) of the knee. The current study will be divided into two parts.
- Trial name
- NCT01310257
- Testing
- Questionnaires
- Where
- 3 sites in United Kingdom
- Volunteers
- 448 people
- Sponsor
- University of Nottingham
Osteoarthritis of Knee
Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis Patients
The goal of this clinical trial is to to clarify which is the best dose of administration, to select a dose and to confirm the therapeutic efficacy of clodronate in patients with painful knee osteoarthritis (OA).
- Trial name
- NCT06263517
- Testing
- Clodronate
- Where
- 11 sites in Italy
- Volunteers
- 296 people
- Sponsor
- SPA Società Prodotti Antibiotici S.p.A.
Arthritis Knee
Comparing Pain and Kinematic Outcomes of Two Gait-Modifying Shoe Interventions
This study involves the use of a newly designed shoe device for knee arthritis patients that may help reduce knee pain and improve function.
- Trial name
- NCT03760380
- Testing
- Sole 1 - Neutral, Sole 1 - Offset, Sole 2 - Neutral
- Sponsor
- University of Florida
Knee Osteoarthristis
Neuromuscular Facilitation Protocol on Pain, Range and Function in KOA
An individual can suffer from knee osteoarthritis, which is a degenerative condition, and while standard physical therapy can assist in some way, improved joint mechanics and decreased functional limitations can be achieved…
- Trial name
- NCT07872280
- Testing
- Standard physical therapy, Neuromuscular Facilitation Protocol
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Postoperative Pain, Inflammation
Steroids in Total Knee Arthroplasty
The purpose of this study is to evaluate if the use of two small doses of intravenous (IV) steroids around the time of knee replacement surgery decrease a patient's pain or use of pain medication.
- Conditions
- Postoperative Pain, Inflammation, Osteoarthritis
- Trial name
- NCT02219581
- Testing
- Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Thomas L Bradbury
Osteoarthritis
Treatment of Osteoarthrosis of the Knee With Platelet Rich Plasma, Comparative Study With Hyaluronic Acid
To compare changes in functionality and pain level using questionnaires EVA, Lequesne and WOMAC in patients treated with 4 doses of 8 ml of autologous Platelet Rich Plasma every 15 days applied through intra-articular…
- Trial name
- NCT03477630
- Testing
- Platelet Rich Plasma, Hyaluronic Acid
- Where
- Costa Rica
- Volunteers
- 28 people
- Sponsor
- Karla Andrea Arias Varela
Osteoarthritis
Pain Expectations in Subjects With Osteoarthritis
The purpose of this research study is to test whether or not researchers can alter or change expectations on pain. The researchers will test whether there is an effect on the size of the pupil and responses to thermal heat…
- Trial name
- NCT02155257
- Testing
- Modafinil, Gabapentin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pain, Osteoarthritis, Knee
Audio-Recorded vs. Nurse-Led Brief Mindfulness-Based Intervention
This is a single-site, three-arm, parallel-group randomized clinical trial (RCT). The clinical effects of a nurse-led, very brief, preoperative mindfulness-based intervention for hip and knee replacement patients will be…
- Conditions
- Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT05054595
- Testing
- Standard Pain Management, Audio-Recorded Mindfulness-Based Intervention, Nurse-Led Mindfulness-Based Intervention
- Sponsor
- University of Utah
Knee Osteoarthritis
The Effect of "Laying on of Hands" in Older Women With Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of chronic degenerative joint disease, as well as the main cause of pain and disability in older persons worldwide.
- Trial name
- NCT02917356
- Testing
- Spiritual laying on of hands (SP), Non-spiritual Laying on of Hands, Control group
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Federal University of Juiz de Fora
Osteo Arthritis Knee
Geniculate Artery Embolization for Knee Pain Secondary to Osteoarthritis (OA)
Purpose: To evaluate embolization as a treatment for OA related knee pain versus placebo to demonstrate the actual effect of embolization on pain and disability.
- Trial name
- NCT03362957
- Testing
- Geniculate Artery Embolization
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis
Effect of Kinesio Taping and Sham Taping in Knee Osteoarthritis
The prevalence of knee osteoarthritis has been increasing in recent decades as the number of obese people has increased. Various interventions are used to improve the functional condition of patients, but it is still not clear…
- Trial name
- OA (NCT05320562)
- Testing
- Kinesio taping
- Where
- Lithuania
- Volunteers
- 30 people
- Sponsor
- Lithuanian Sports University
Osteoarthritis, Knee, Pain, Chronic
Management of Knee Pain by Cooled Radiofrequency in Classical Anatomical Targets and Revised Targets
Osteoarthritis (OA) is a chronic and progressive disease that results from characteristic pathological changes in the tissues of the entire joint, resulting in failure in the component parts.
- Conditions
- Osteoarthritis, Knee, Pain, Chronic, Analgesia
- Trial name
- NCT05363241
- Testing
- Cooled radiofrequency in classical targets (CRF-CT), Cooled radiofrequency in revised targets (CRF-RT)
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Universidade Federal de Alfenas
Osteoarthritis
A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain
Osteoarthritis is a degenerative joint disease and is the most common form of arthritis. This study will evaluate the effectiveness of customized shoe inserts in controlling and relieving the pain of knee osteoarthritis.
- Trial name
- NCT00076453
- Testing
- Lateral wedge orthotic shoe inserts, Standard orthotic shoe inserts
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center