Clinical trials: Osteoarthritis Of Knee
Osteoarthritis
First-in-human Study With Ascending Single Intra-articular Doses of GZ389988 in Patients With Painful Osteoarthritis of the Knee
Primary Objective: To assess the safety and tolerability of ascending single intraarticular doses of GZ389988 in patients with painful osteoarthritis (OA) of the knee.
- Trial name
- NCT02424942
- Testing
- GZ389988
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Genzyme, a Sanofi Company
Osteoarthritis, Knee
Predicting Poor Outcomes After Primary Knee Arthroplasty
Aim To identify through data analysis key patients, surgeon and operative dependent variables which will improve the performance of knee replacement for primary osteoarthritis Research Question 1.
- Trial name
- NCT01765699
- Testing
- Primary knee arthroplasty
- Volunteers
- 1,300 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Osteoarthritis of the Knee
A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee
This is a Phase 2 study, involving a 4-week treatment period, designed to test the ability of investigational study drug ARRY-371797 to reduce pain in patients with moderate to severe pain due to osteoarthritis (OA) of the knee…
- Trial name
- NCT01366014
- Testing
- ARRY-371797, p38 inhibitor; oral, Oxycodone hydrochloride (HCl) extended release (ER), opioid agonist; oral
- Where
- 13 sites in United States
- Volunteers
- 157 people
- Sponsor
- Pfizer
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Predicting Outcome of Total Knee Replacement Surgery in Patients With Knee Osteoarthritis
Osteoarthritis (OA) is the main cause of pain and disability in elderly. For knee OA, a total knee replacement (TKR) is an effective surgical treatment, and the majority of patients report substantial pain relief and functional…
- Trial name
- NCT05380648
- Testing
- Total knee arthroplasty
- Where
- Belgium
- Volunteers
- 223 people
- Sponsor
- Universiteit Antwerpen
Osteoarthritis, Musculoskeletal Abnormalities
Prospective Evaluation Assessing U2 MB™ Total Knee System
The goal of this study is to evaluate the safety and effectiveness of the United Orthopaedics Mobile Bearing Total Knee System (U2 MB™ Knee) in patients undergoing total knee replacement surgery due to end-stage knee…
- Trial name
- NCT06996158
- Volunteers
- 150 people
- Sponsor
- MSK Doctors & Associates Ltd
Osteo Arthritis Knee, Quadriceps Muscle Atrophy
Effect of Physical Therapy Modalities in Osteoarthritis
The purpose of this study was to find the most effective treatment out of both techniques; Dry needling and Kinesio Taping for treating knee osteoarthritis (OA) in terms of pain, strength, and balance
- Trial name
- NCT05089253
- Testing
- Dry Needling, Kinesio tapping
- Where
- India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Majmaah University
Knee Pain Chronic, Rheumatoid Arthritis
Cemented vs Cementless Persona Keel RCT
The main objective of this study is to evaluate the safety, performance, and clinical benefits of the Persona Keel cementless and cemented knee.
- Conditions
- Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT05630053
- Testing
- Cementless Persona Knee System, Cemented Persona Knee System
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Real-life Use of BENART TM in Patients With Symptomatic Knee Osteoarthritis
PMCF study to assess the effectiveness and safety of BENART in the treatment of symptomatic knee OA in a real-life clinical setting when used according to the instructions for use.
- Trial name
- NCT04757051
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- TRB Chemedica AG
Pain
An Efficacy and Safety Study of Acetaminophen Plus Tramadol Hydrochloride (JNS013) in Participants With Chronic Pain
The purpose of this study is to evaluate the efficacy and safety of tramadol hydrochloride plus acetaminophen (JNS013) in participants with chronic pain accompanied by osteoarthritis (a progressive and degenerative joint disease…
- Trial name
- NCT00736853
- Testing
- Tramadol Hydrochloride Plus Acetaminophen (Open-Label), Tramadol Hydrochloride Plus Acetaminophen (Double-Blind)
- Where
- 20 sites in Japan
- Volunteers
- 321 people
- Sponsor
- Janssen Pharmaceutical K.K.
Osteoarthritis
Standard Total Knee Arthroplasty Using Platelet Rich Plasma (PRP)
Clinical study to determine if there is a difference in hemoglobin level between patients undergoing total knee arthroplasty with and without platelet-rich plasma.
- Trial name
- NCT01075230
- Testing
- Total knee arthroplasty
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Exactech
Knee Osteoarthritis
Evaluation of the Effect of SURGICEL® Powder in TKA
The study subjects are patients in our hospital's orthopedics department undergoing unilateral primary total knee arthroplasty (TKA) due to primary osteoarthritis.
- Trial name
- NCT06608992
- Testing
- SURGICEL® Powder
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Peking University Third Hospital
Knee Arthropathy, Knee Osteoarthritis
NLR and PLR Levels Following IPACK Block in Knee Arthroplasty
Effect of iPACK block on NLR and PLR following knee arthroplasty
- Conditions
- Knee Arthropathy, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NCT06304298
- Testing
- 0.9% Sodium Chloride Injection, Ropivacaine 0.2% Injectable Solution
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Knee Osteoarthritis
A Clinical Trial of YH23537 in Patients With Knee Osteoarthritis
The purpose of this study is to evaluate efficacy and safety of YH23537 versus celebrex in patients with knee osteoarthritis.
- Trial name
- NCT02759198
- Testing
- YH23537, Celecoxib
- Where
- South Korea
- Volunteers
- 456 people
- Sponsor
- Yuhan Corporation
Knee Osteoarthritis
Comparison of the Efficacy of Duloxetine and Pregabalin in Patients With Knee Osteoarthritis With Mix Type Pain
Osteoarthritis (OA) is a common degenerative joint disorder associated with chronic pain at older age.It is known that patients with osteoarthritis experience nociceptive and neuropathic pain to varying degrees.
- Trial name
- NCT04532684
- Testing
- Duloxetine, Pregabalin
- Volunteers
- 66 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Anesthesia Morbidity, Osteoarthritis, Knee
Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System
The study is a retrospective cohort study of adult patients undergoing outpatient primary unilateral total knee or total hip replacement surgeries from 2017 to 2019 assessing for difference in anesthetic techniques and outcomes.
- Conditions
- Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT04203732
- Testing
- Anesthesia Type
- Where
- United States
- Volunteers
- 12,466 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Knee Osteoarthritis
Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis
Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing…
- Trial name
- NCT04423432
- Testing
- Lower Extremity Resistance Exercise Training, Home Exercise Plan, Electrotherapy + Heating
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Osteoarthritis
Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis
The present study will aim to evaluate the efficacy of milnacipran in the treatment of pain due to osteoarthritis (OA), that is, to determine whether milnacipran provides superior efficacy to placebo in patients with OA.
- Trial name
- NCT01329406
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Analgesic Solutions
Osteoarthritis, Knee, Quality of Life
Yoga for Managing Knee Osteoarthritis in Older Women: a Feasibility Study
The study hypothesized that it is feasible and safe to use Hatha yoga in older women with knee osteoarthritis (OA), and practicing Hatha yoga regularly will help reduce pain and stiffness, enhance physical function, and improve…
- Conditions
- Osteoarthritis, Knee, Quality of Life, Poor Quality Sleep, Physical Impairment
- Trial name
- NCT01832155
- Testing
- Hatha yoga
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Osteoarthritis, Knee
Study of the KinexConnect Telerehabilitation System (KCTRS)
A randomized, single-blind study comparing telerehabilitation at home with continuous passive motion (CPM) and a tablet-based patient engagement application (KinexConnect) versus traditional outpatient physical therapy (PT)…
- Trial name
- KCTRS (NCT04191798)
- Testing
- Telerehabilitation using the KinexConnect system for rehabilitation after TKA., Traditional outpatient PT for rehabilitation after TKA.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kinex Medical Company, LLC
Osteoarthritis
Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis (OA)
This 39-week, active controlled, study is designed to assess long-term efficacy, safety and tolerability of lumiracoxib 100mg od in patients with osteoarthritis (OA) of the knee who participated in the 13-week core CCOX189A2361…
- Trial name
- NCT00476034
- Testing
- lumiracoxib
- Where
- 15 sites in Australia, Austria and 13 more
- Volunteers
- 1,312 people
- Sponsor
- Novartis
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