Clinical trials: Osteoarthritis Pain
Knee Osteoarthritis
Effect of a Patient Education in Pain Coping for Patients Scheduled for Total Knee Arthroplasty
The aim of this study is to investigate, whether a patient education with focus on pain coping is able to improve physical function and experienced pain level in patients with high levels of pain catastrophizing before Total Knee…
- Trial name
- NCT02587429
- Testing
- Patient education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Regional Hospital West Jutland
Arthritis, Arthritis/Arthrosis
Combining Virtual Reality and Hypnosis to Alleviate Chronic Pain in Elderly Patients with Hand Arthritis
The goal of this pilot randomized clinical trial is to test the efficacy of an intervention combining virtual reality and hypnosis on decreasing pain and improving quality of life in elderly patients with hand arthritis.
- Conditions
- Arthritis, Arthritis/Arthrosis, Arthritis, Rheumatoid, Elderly
- Trial name
- VRHArthrisis (NCT06833905)
- Testing
- Virtual reality: Beach, Virtual Reality: Forest, Hypnosis: Magic Hand
- Volunteers
- 80 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Osteoarthritis, Knee
A Controlled Study of an Herbal Topical Patch in Treating Osteoarthritis (OA) of the Knee
An evaluation of the safety and efficacy of an herbal patch in treating osteoarthritis pain of the right or left knee.
- Trial name
- NCT01183624
- Testing
- Herbal Patch
- Where
- 12 sites in China
- Volunteers
- 626 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Osteoarthritis of the Shoulder, Osteoarthritis of the Hip
Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip
This is an open-label study to compare systemic exposure to triamcinolone acetonide following a dose of extended-release FX006 or immediate-release TAcs (triamcinolone acetonide suspension) in patients with osteoarthritis of the…
- Trial name
- NCT03382262
- Testing
- FX006 32 mg, TAcs 40 mg
- Where
- 6 sites in United States
- Volunteers
- 55 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee
Efficacy and Safety of a Intra-articular Injection, ENKO1, in Patients With Symptomatic Knee Osteoarthritis.
Clinical trial with medical device, multicenter, single-blind (blind third party evaluation), randomized, comparative and in two paralell groups, to demonstrate the treatment according to usual clinical practice, of the…
- Trial name
- ENKORE (NCT03762408)
- Testing
- ENKO 1, Durolane
- Where
- 18 sites in Spain
- Volunteers
- 175 people
- Sponsor
- OPKO Health, Inc.
Osteoarthritis of Knee
Pain Relief for OsteoArthritis Through Combined Treatment (PROACT)
This mechanistic clinical trial proposes to test whether a five-day course of mindfulness meditation training (MMT) and tDCS, and their combination, can enhance pain modulatory balance and pain-related brain function, reduce…
- Trial name
- PROACT (NCT03884374)
- Testing
- Focused Breathing and Attention Training (BAT), Standard Breathing and Attention Training (BAT), Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 317 people
- Sponsor
- University of Florida
Total Knee Replacement, Osteoarthritis of the Knee
Effectiveness of Osteopathy in the Preoperative Treatment of Postoperative Pain in Patients Undergoing Total Knee Replacement
Osteopathy is an alternative healthcare that seems effective in relieving the pain of patients. The main purpose of this study is to evaluate the efficacy of preoperative osteopathic care in patients undergoing total knee…
- Conditions
- Total Knee Replacement, Osteoarthritis of the Knee, Preoperative Osteopathic Care
- Trial name
- NCT01989117
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospital Ambroise Paré Paris
Knee Osteoarthritis, Pain
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)
Knee osteoarthritis (KOA) is one of the most common causes of chronic pain, mobility problems, and disability among United States Veterans.
- Conditions
- Knee Osteoarthritis, Pain, Depression
- Trial name
- DRIVE (NCT07649291)
- Testing
- Exercise, Duloxetine, PT referral
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pain, Osteoarthritis, Hip
Modulation of the Surgical Inflammatory Response by Etoricoxib
The purpose of this study is to test the hypothesis that orally administered etoricoxib (COX-2) modulates prostaglandin and cytokine synthesis in the central nervous system (CNS) and in the periphery in surgical patients and thus…
- Conditions
- Pain, Osteoarthritis, Hip, Postoperative Pain
- Trial name
- NCT00746720
- Testing
- Etoricoxib 60 mg
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Knee Osteoarthritis
Benefits of Spa Therapy in Saint-Lary Soulan for Knee Osteoarthritis
The hypothesis is that the use of spa therapy in Saint-Lary Soulan for knee osteoarthritis treatment would have a therapeutic effect on this pathology.
- Trial name
- LARYTHERM (NCT05790824)
- Testing
- Spa therapy
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University of Bordeaux
Osteoarthritis, Knee
Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain
This is a multi-center, randomized, double-blind, parallel group, placebo controlled trial to compare the safety and effectiveness of a single injection of Cingal® to a single injection of Triamcinolone Hexacetonide (TH) to…
- Trial name
- NCT04231318
- Testing
- Cingal, Triamcinolone Hexacetonide (TH)
- Where
- 26 sites in United States
- Volunteers
- 231 people
- Sponsor
- Anika Therapeutics, Inc.
Pain, Osteoarthritis, Knee
Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee
The purpose of the study is to evaluate the safety and effectiveness of the investigational ketoprofen patch with a controlled heating patch, compared to placebo (inactive substance) for the treatment of pain caused by…
- Trial name
- NCT00108810
- Testing
- Transdermal Ketoprofen Patch with CHADD
- Where
- 5 sites in United States
- Volunteers
- 118 people
- Sponsor
- ZARS Pharma Inc.
Knee Osteoarthritis
Combined Application of Electrical Stimulation and Volitional Contractions for Muscle Strengthening and Knee Pain Inhibition (Seated Study)
The purpose of this study is to assess the efficacy of a 12-week low-load neuromuscular electrical stimulation with volitional contraction (NMES-VC) training program to improve quadriceps strength and activation, while not…
- Trial name
- NCT02802878
- Testing
- Hybrid Training using Electrodes and Joint Motion Sensors, Isokinetic Training with Isokinetic Dynamometer
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Kansas Medical Center
Chronic Low Back Pain, Hip Ostearthritis
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
Back pain is a huge problem for millions of Americans, including nearly 11 million Veterans. Our older Veterans suffer the most. Citizens spend billions of dollars, yet consistently get poor results.
- Conditions
- Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia
- Trial name
- NCT02697435
- Testing
- Patient-Centered Care, Imaging-Directed Care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Chronic Pain Syndrome
Thermal Micro-cautery for Painful Knee Osteoarthritis
To trial a traditional pain management technique from Ayurveda in a modern way - the technique involves micro - cautery to painful areas in knee osteoarthritis for patients on a waiting list for knee replacement.
- Trial name
- TMC-PKO (NCT03460717)
- Testing
- Peripheral Nerve Field Stimulation by Thermal Micro-Cautery
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- The National Children's Hospital, Tallaght
Osteoarthritis
A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems
The primary objective of this investigation is to test the hypothesis that the Duofix Tibial component results in a reduction of immediate postoperative pain compared to the LCS Porocoat version.
- Trial name
- NCT00733499
- Testing
- LCS Complete Duofix, LCS Complete Porocoat
- Where
- Ireland
- Volunteers
- 206 people
- Sponsor
- DePuy International
Osteoarthritis, Knee
Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain
Evaluation of Safety, Tolerability, and Efficacy of XT-150, a plasmid DNA with a variant of human IL-10 transgene. XT-150 will be a single injection into the knee synovial capsule for the Treatment of Osteoarthritic Pain.
- Trial name
- NCT03477487
- Testing
- XT-150
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Xalud Therapeutics, Inc.
Knee Osteoarthritis
Exercise and Pain Sensitivity in Knee Osteoarthritis
A commonly administered conservative non-pharmacological treatment for OA is exercise, with beneficial effects in terms of reduced pain and disability. While the link between exercise and reduced disability is mediated by e.g.
- Trial name
- NCT01545258
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Frederiksberg University Hospital
Chronic Knee Pain, Chronic Knee Osteoarthritis
Treating Chronic Pain of Peripheral Nerve Origin With the Novel Noninvasive Hypersound Neuromodulation System
First, the subject will undergo screening and provide informed consent. Baseline measurements are then taken. The subject remains seated with back support throughout the session.
- Conditions
- Chronic Knee Pain, Chronic Knee Osteoarthritis, Post Surgical Neuropathic Pain
- Trial name
- NCT06626854
- Testing
- RF-PNS
- Volunteers
- 5 people
- Sponsor
- Hypersound Medical Inc
Shoulder Arthropathy Associated With Other Conditions, Shoulder Arthritis
Microcurrent Dressing to Treat Infections, Before, During and After Surgery
Deep periprosthetic infection following total joint arthroplasty is a major complication. Although it only occurs in a small percentage of patients (~1%), it results in substantial morbidity and a decline in functional outcome.
- Conditions
- Shoulder Arthropathy Associated With Other Conditions, Shoulder Arthritis, Shoulder Osteoarthritis, Shoulder Pain
- Trial name
- NCT03156543
- Testing
- Jumpstart Dressing, Standard Dressing
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
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