Clinical trials: Osteoarthritis Pain
Postoperative Pain, Inflammation
Steroids in Total Knee Arthroplasty
The purpose of this study is to evaluate if the use of two small doses of intravenous (IV) steroids around the time of knee replacement surgery decrease a patient's pain or use of pain medication.
- Conditions
- Postoperative Pain, Inflammation, Osteoarthritis
- Trial name
- NCT02219581
- Testing
- Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Thomas L Bradbury
Osteoarthritis, Knee
A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee
To evaluate the safety and tolerability of single IV doses of PF-04383119 in Japanese patients with moderate to severe pain from OA of the knee (Part I).
- Trial name
- NCT00669409
- Testing
- PF-04383119 (tanezumab)
- Where
- 12 sites in Japan
- Volunteers
- 83 people
- Sponsor
- Pfizer
Patellofemoral Pain Syndrome, Patellofemoral Osteoarthritis
Measurement Properties of the Turkish Version of the Patellofemoral Pain and Osteoarthritis Subscale of the KOOS
The purpose of this study is to translate and culturally adapt the subscale of the Knee Injury and Osteoarthritis Outcome Score for patellofemoral pain and osteoarthritis (KOOS-PF) into Turkish, and to determine the measurement…
- Conditions
- Patellofemoral Pain Syndrome, Patellofemoral Osteoarthritis, PROMs
- Trial name
- NCT06060730
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Gazi University
Diabetes, Hypertension
Quality IQ Patient Simulation Physician Practice Measurement and Engagement
This study will test the quality of physician care decisions using a patient-simulation based measurement and feedback approach that combines multiple-choice care decisions with real-time, personalized scoring and feedback.
- Conditions
- Diabetes, Hypertension, Depression, Osteoarthritis
- Trial name
- Q-IQ (NCT03800901)
- Testing
- Continuing Medical Education, Quality IQ Patient Simulations
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Knee Osteoarthritis
Proprioceptive Exercises on Joint Pain and QoL Among Geriatric Patients With Knee Osteoarthritis
Knee osteoarthritis, the disease of knee joint pain caused by joint degeneration, it is the commonest joint disease and had a negative effect on geriatric patients' quality of life (QoL).
- Trial name
- NCT06574334
- Testing
- Proprioceptive exercise
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Assiut University
Osteo Arthritis Knee, Quadriceps Muscle Atrophy
Effect of Physical Therapy Modalities in Osteoarthritis
The purpose of this study was to find the most effective treatment out of both techniques; Dry needling and Kinesio Taping for treating knee osteoarthritis (OA) in terms of pain, strength, and balance
- Trial name
- NCT05089253
- Testing
- Dry Needling, Kinesio tapping
- Where
- India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Majmaah University
Osteoarthritis, Quality of Life
Quality-of-life and Pain After Spa Treatment in Elderly With Osteoarthritis
The aim of the study was to evaluate the short- and long-term effects of spa therapy on quality of life and pain in patients aged 65 years and older with osteoarthritis.
- Conditions
- Osteoarthritis, Quality of Life, Elderly, Balneology
- Trial name
- NCT03388801
- Testing
- Spa therapy
- Volunteers
- 70 people
- Sponsor
- University of Rzeszow
Joint Disease
Post Market Clinical Follow-Up Study Protocol for PROFEMUR® L Revision Femoral Stems
MicroPort Orthopedics (MPO) is conducting this PMCF study to evaluate the safety and efficacy of its THA and resurfacing components marketed in the EU.
- Trial name
- NCT02314702
- Testing
- PROFEMUR® L Revision Femoral Stem
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- MicroPort Orthopedics Inc.
Knee Osteoarthritis
Biofreeze® vs. a Placebo on Knee Osteoarthritis Walking Gait Characteristics and Pain
The purpose of this study is to determine the effect of Biofreeze® versus a placebo on walking gait characteristics and pain during walking in individuals with bilateral knee osteoarthritis (OA).
- Trial name
- NCT03888807
- Testing
- Biofreeze
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sport and Spine Rehab Clinical Research Foundation
Total Knee Replacement
In-Clinic Versus Tele-Rehabilitation in Women With Knee Osteoarthritis
To compare the effectiveness of in clinic rehabilitation versus tele rehabilitation in improving knee function in women diagnosed with knee OA. To assess the impact of both rehabilitation approaches on improving strength.
- Trial name
- NCT07654309
- Testing
- In-Clinic Rehabilitation, Tele-Rehabilitaion
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Osteo Arthritis Knee, Pain
Exercise-related Irisin on Inflammation and Pain
Osteoarthritis (OA) is a chronic disease that usually starts with cartilage damage in weight-bearing joints and then causes pain and loss of function secondary to damage in surrounding tissues.
- Conditions
- Osteo Arthritis Knee, Pain, Inflammation
- Trial name
- NCT05388994
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Firat University
Coxarthrosis; Primary
Efficacy of Pulse Radiofrequency Treatment in Patients With Coxarthrosis
Our aim in this interventional study is to investigate the effectiveness of pulsed radiofrequency (PRF) treatment applied to the articular branches of the femoral and obturator nerves on pain, functional level, functional…
- Trial name
- NCT06034418
- Testing
- Pulse radiofrequency treatment, Nerve block with 1 cc betamethasone and 1 cc 1% lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis, Total Knee Arthroplasty
Adductor Canal Block Methods in Bilateral Total Knee Arthroplasty
This study aims to compare the analgesic efficacy of surgeon-performed intraoperative adductor canal block (ACB) and ultrasound-guided anesthesiologist-performed ACB in patients undergoing bilateral total knee arthroplasty (TKA).
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Postoperative Pain, Peripheral Nerve Block
- Trial name
- NCT07506629
- Testing
- Surgeon-Performed Adductor Canal Block, Ultrasound-Guided Adductor Canal Block
- Volunteers
- 48 people
- Sponsor
- Yonsei University
Osteo Arthritis Knee, Pain
Use of a Self-Guided Mindfulness Mobile Application to Improve Pain Outcomes in Individuals With Knee Osteoarthritis
This study will investigate if mindfulness training via a smartphone mobile app is effective in improving OA-related knee pain.
- Trial name
- NCT03936088
- Testing
- Intervention -- "Headspace" mindfulness application, Control -- "My Water Balance" application
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- jilliansylvester
Pain, Osteoarthritis
A Two-Arm Study Comparing the Analgesic Efficacy and Safety of Tramadol HCl Once-a-Day Versus Placebo for the Treatment of Pain Due to Osteoarthritis
The purpose of this study is to compare the analgesic efficacy, safety and clinical benefit of Tramadol OAD tablets versus Placebo.
- Trial name
- NCT00833794
- Testing
- Tramadol Once a day
- Volunteers
- 1,028 people
- Sponsor
- Labopharm Inc.
Degenerative Joint Disease
Hyaluronic Acid and Adelmidrol (Hyadrol®) in Patients With Degenerative Joint Disease
Osteoarthritis is a major cause of chronic musculoskeletal pain. Behind this disorder there is a process of chronic neuroinflammation due to the overactivation of mast cells at the tissue level.
- Trial name
- NCT06506656
- Testing
- Hyadrol®
- Where
- Italy
- Volunteers
- 59 people
- Sponsor
- University of Roma La Sapienza
Osteoarthritis of the Knee
Study to Assess the Safety of Repeat Administration of FX006 Administered to Patients With Osteoarthritis of the Knee
This is an Open-label Study to Assess the Safety of Repeat Dose of FX006 Administered to Patients with Osteoarthritis (OA) of the Knee
- Trial name
- NCT03046446
- Testing
- FX006 32 mg
- Where
- 17 sites in United States
- Volunteers
- 208 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee Arthritis Osteoarthritis
The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties
Total knee arthroplasty (TKA) is a very common operation that increases in frequency with advancing age. Similar to other surgical procedures, strategies are being developed to minimize morbidity and mortality while allowing for…
- Conditions
- Osteoarthritis, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- NCT07236073
- Testing
- PRİMER TEK TARAFLI DİZ ARTOPLASTİSİNDE İKİ FARKLI ANALJEZİK YÖNTEMİ, knee replacement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Osteoarthritis of Knee
A Phase 1/2a to Evaluate the Safety and Efficacy of Adipose Tissue Allograft (BRC-OA) in Patients With Osteoarthritis of the Knee
The purpose of this study is to evaluate the safety profile of BRC-OA for pain treatment in patients with mild to severe OA of the knee, focusing particularly on two distinct doses.
- Trial name
- NCT06828666
- Testing
- Cryopreserved Devitalized Adipose Tissue Allograft
- Where
- 7 sites in United States
- Volunteers
- 46 people
- Sponsor
- Britecyte
Osteoarthritis, Knee
Multimodal Drug Infiltration in Total Knee Arthroplasty: Is Posterior Capsular Infiltration Worth the Risk?
Multimodal local anesthetic infiltration (LAI) provides effective pain control in patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT02860949
- Testing
- 0.5% bupivacaine 100 mg, morphine sulfate 5 mg, 0.1% epinephrine 0.6 mg, and ketorolac 30 mg mixed NSS up to 100 mL, Drug injection at Anterior soft tissue (25 mL)+Medial gutter area (25 mL)+Lateral gutter area (25 mL)+Posterior capsular infiltration (25 mL), Drug injection at Anterior soft tissue (34 mL)+Medial gutter area (33 mL)+Lateral gutter area (33 mL
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Thammasat University