Clinical trials: Osteoarthritis Pain
Osteoarthritis (OA) of the Knee
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
The goal of this clinical trial is to learn if a single knee injection of different doses (Dose A and Dose B) of an investigation product PCRX-201, following steroid pretreatment, is safe and tolerable in male of female patients…
- Trial name
- NCT06884865
- Testing
- Enekinragene Inzadenovec (PCRX-201)
- Where
- 40 sites in United States
- Volunteers
- 135 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI
Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study
This study will observe patients with lower limb varicose veins who also have knee pain. Many patients with varicose veins experience swelling, heaviness, or aching in the legs, and some also report pain in or around the knee.
- Conditions
- Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI, Knee Pain Chronic, Knee Osteoarthritis
- Trial name
- VV-KNEE (NCT07163312)
- Testing
- Endovenous Ablation for Varicose Veins
- Volunteers
- 50 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Arthritis
Gold Against Pains From Osteoarthrosis in the Knee
Gold implantation around arthritic joints is a very popular treatment - but the effect has never been controlled.
- Trial name
- NCT00378339
- Testing
- gold berlocks
- Where
- Denmark
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis, Obesity
Liraglutide 3 mg for Knee Osteoarthritis
A randomised, double blind, placebo-controlled, parallel group, and single-centre trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis.
- Trial name
- LOSEIT (NCT02905864)
- Testing
- Liraglutide 3 mg (Saxenda)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Henrik Gudbergsen
Knee Osteoarthritis (Knee OA), Chronic Pain
Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis (Knee OA), Chronic Pain, Chronic Knee Pain
- Trial name
- PACE-UP (NCT07759336)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Benedict Alter
Knee Osteoarthritis
Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis
Gonarthrosis is a chronic pathology affecting the knee joint and tissues. It is characterized by progressive degeneration of articular cartilage, bone and surrounding structures.
- Trial name
- PAGONA (NCT07016672)
- Testing
- intra-articular injection of HA, intra-articular injection of PRP
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Osteoarthritis in the Knee
The Effect of Low Intensity Ultrasound Therapy on Chronic Pain Due to Osteoarthritis of the Knee.
To evaluate a new, low intensity ultrasound device in the treatment of chronic pain due to osteoarthritis in the knee. Enhancing CBD oil penetration into joints by sonophoresis.
- Trial name
- NCT03679507
- Testing
- Low Intensity Ultrasound Therapy, Enhancing CBD oil penetration into joints by sonophresis
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Dr. Kevin Rod
Hyaluronate, Osteoarthritis
Efficacy of Three Weekly Injections of a Bacterial-- Sourced Hyaluronate on Pain and Function in Patients With Knee Osteoarthritis (OA)
Three weekly injections of hyaluronate (Hya-Joint) are safe and well tolerated, provide rapid pain relief as early as 1 and 2 weeks after the first injection, and improve function in patients with knee osteoarthritis.
- Conditions
- Hyaluronate, Osteoarthritis, Knee
- Trial name
- NCT01185444
- Testing
- Hya-Joint, Hyalgan
- Where
- Taiwan
- Volunteers
- 89 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Osteoarthritis, Shoulder Pain
Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis
This study seeks to expand the current literature in demonstrating potentially efficacious, conservative treatments in the management of glenohumeral osteoarthritis (OA) and will compare ultrasound-guided injections of hyaluronic…
- Trial name
- NCT02984228
- Testing
- PRP, Hyaluronic Acid, Ultrasound
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis of the Shoulder, Osteoarthritis of the Hip
Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip
This is an open-label study to compare systemic exposure to triamcinolone acetonide following a dose of extended-release FX006 or immediate-release TAcs (triamcinolone acetonide suspension) in patients with osteoarthritis of the…
- Trial name
- NCT03382262
- Testing
- FX006 32 mg, TAcs 40 mg
- Where
- 6 sites in United States
- Volunteers
- 55 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
Comparing Femoral Nerve Catheters to Single Shot Femoral Nerve Blocks for Total Knee Replacement Surgery
The purpose of this study is to compare two methods of pain control used during total knee joint replacement surgery. The pain medication that will be used for this study is not experimental.
- Trial name
- NCT02106481
- Testing
- Femoral Nerve Catheters, Single Shot Femoral Nerve Blocks
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Eastern Maine Medical Center
Osteoarthritis
Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
This study will determine whether glucosamine, chondroitin sulfate and/or the combination of glucosamine and chondroitin sulfate are more effective than placebo and whether the combination is more effective than glucosamine or…
- Trial name
- NCT00032890
- Testing
- glucosamine, chondroitin sulfate, glucosamine and chondroitin sulfate combined
- Where
- 16 sites in United States
- Volunteers
- 1,588 people
- Sponsor
- US Department of Veterans Affairs
Musculoskeletal Pain, Knee Osteoarthritis
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life.
- Conditions
- Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
- Trial name
- NCT03477942
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Osteoarthritis, Knee
Diadynamic and Exercises in Knee Osteoarthritis
Osteoarthritis represents failed repair of joint damage resulting from stresses initiated by any joint or periarticular tissue abnormality. The rate of progression varies among persons and within a knee over time.
- Trial name
- NCT05159986
- Testing
- Group that received aplication of Diadynamic currents associated to Exercise during eight weeks with three sessions a week, Group that received exercise during eight weeks with three sessions a week
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Severe Osteoarthritis of the Knee
Study of Ampion for the Treatment of Pain and Function in Patients With Severe Osteoarthritis of the Knee.
The purpose of this study is to confirm the safety and efficacy of Ampion for the treatment of pain and function in patients with severe osteoarthritis of the knee.
- Trial name
- NCT03988023
- Testing
- Ampion, Saline
- Where
- United States
- Volunteers
- 1,043 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Osteoarthritis
Prospective Multicenter Non-interventional Study in Patients With Knee or Hip Osteoarthritis Having a Theraflex Treatment
The main purpose of this study is to evaluate how a long-term treatment with Theraflex during 64 weeks affects pain intensity in the affected knee or hip joint, the activity in daily living, the quality of life and patient…
- Trial name
- NCT03330288
- Testing
- Theraflex, BAY 874017
- Where
- 2 sites in Russia
- Volunteers
- 1,102 people
- Sponsor
- Bayer
Knee Osteoarthritis (Knee OA)
Cross-linked Hyaluronic Acid in Knee Osteoarthritis
Knee Osteoarthritis (Knee OA) leads to pain and loss of function, especially in recreational athletes. While hyaluronic acid (HA) injections are a common part of conservative treatment, comparative data on the efficacy of…
- Trial name
- NCT07241442
- Testing
- Straight-bonded hyaluronic acid, cross-linked hyaluronic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Knee Osteoarthritis
Pain Sensitization and Outcome Following Physiotherapy in Patients With Knee Osteoarthritis
Pain is the dominant symptom of knee osteoarthritis and recent evidence suggests factors outside of local joint pathology, such as pain sensitization, can contribute significantly to the pain experience.
- Trial name
- NCT02310945
- Testing
- Physiotherapy
- Where
- 3 sites in Ireland
- Volunteers
- 140 people
- Sponsor
- University College Dublin
Knee Osteoarthritis
A Study of Alendronate Sodium Vitamin D3 Tablets on Knee Osteoarthritis
The purpose of this study is to evaluate the effect of alendronate sodium vitamin D3 tablets compared with placebo on the improvement of joint structure and joint pain in participants with knee osteoarthritis.
- Trial name
- NCT04739592
- Testing
- alendronate sodium vitamin D3 tablets
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Knee Osteoarthritis
A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain
There is an urgent public health need to reduce reliance on opioids for effective long-term pain management, particularly in knee osteoarthritis (KOA).
- Trial name
- SKOAP (NCT04504812)
- Testing
- Duloxetine, Intra-Articular Injection, Nerve Procedure with long acting blocks
- Where
- 24 sites in United States
- Volunteers
- 1,937 people
- Sponsor
- Johns Hopkins University