Clinical trials: Osteoarthritis Pain
Osteoarthritis of the Knee
To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients of the Knee
This is a randomized, double-blind study to compare the efficacy and safety of LAYLA tablet and CENATONE tablet in the treatment of osteoarthritis of the knee.
- Trial name
- NCT02049606
- Testing
- LAYLA tablet, CENATONE tablet
- Where
- 6 sites in South Korea
- Volunteers
- 134 people
- Sponsor
- PMG Pharm Co., Ltd
Knee Pain, Osteoarthritis
The Effects of the Electro, Heat and Cold -Therapy During Physiotherapy Treatment in Osteoarthritis(OA) of KNEE
The objective of this clinical trial is to evaluate the pain relief and daily functioning improve, in patients suffering of Osteoarthritis of knee, with HOT/COLD/ Electro therapy during physiotherapy treatment
- Trial name
- NCT01112319
- Testing
- Elf care, control group
- Where
- Israel
- Sponsor
- Meir Medical Center
Knee Osteoarthritis
A Study of Single and Repeat Dose Administration of UBX0101 in Patients With Osteoarthritis of the Knee
A study to assess safety, tolerability and clinical effects of single and repeat dose intra-articular administration of UBX0101 in patients with moderate to severe painful knee osteoarthritis (OA).
- Trial name
- NCT04229225
- Testing
- UBX0101
- Where
- 7 sites in United States
- Volunteers
- 35 people
- Sponsor
- Unity Biotechnology, Inc.
Osteoarthritis, Knee
Genicular Radiofrequency Ablation Following Total Knee Arthroplasty
Currently, nearly 1 million total knee arthroplasties (TKA) are performed yearly in the United States. Three million are projected to be performed in 2040.
- Trial name
- GRATKA (NCT05283889)
- Testing
- Genicular Radiofrequency Ablation
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Osteoarthritis of the Knee
HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain
Ketoprofen in a topical patch formulation has been demonstrated to be effective for treating mild to moderate pain caused by various musculoskeletal disorders.
- Trial name
- NCT00792727
- Testing
- ketoprofen Patch
- Where
- 36 sites in United States
- Volunteers
- 380 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Knee Osteoarthritis, Osteo Arthritis Knee
Effectiveness of Physical Therapy in Stem Cell Transplant Recipients for Knee Osteoarthritis
Knee osteoarthritis has been considered as 11th highest contributor factor to nonfatal burdens in the world. It is considered one of the most common degenerative diseases of synovial joint and major cause of muscle impairment…
- Conditions
- Knee Osteoarthritis, Osteo Arthritis Knee, OA Knee
- Trial name
- NCT05959902
- Testing
- Forward Walking, Physiotherapy Exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 48 people
- Sponsor
- Dow University of Health Sciences
Knee Osteoarthritis
Effects of α MAT Versus Steroid Injection in Knee Osteoarthritis (STα MAT-knee Study)
Knee Osteoarthritis (OA) is a common degenerative knee condition of the knee which is treated symptomatically. Knee cartilage tissue has little regenerative ability With the developments in regenerative medicine, stem cells might…
- Trial name
- NCT04230902
- Testing
- Microfragmented Adipose Tissue Transplant, Corticosteroid injection
- Where
- Lebanon
- Volunteers
- 48 people
- Sponsor
- American University of Beirut Medical Center
Osteoarthritis of the Hip, Postoperative Pain
FRONT Block for Quality of Recovery After Total Hip Arthroplasty
This prospective randomized controlled trial evaluates the effect of ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block on postoperative quality of recovery in patients undergoing elective total hip…
- Conditions
- Osteoarthritis of the Hip, Postoperative Pain, Quality of Recovery
- Trial name
- NCT07458360
- Testing
- FRONT Block (Femoral Rami and Obturator Nerve Trunk Block), Standard Multimodal Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya Meram State Hospital
Osteoarthritis, Knee, Total Knee Arthroplasty
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent…
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
- Trial name
- NCT06083480
- Testing
- GlyNAC (combination of glycine and n-acetylcysteine)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Vanderbilt University Medical Center
Knee Osteoarthritis
Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty
The purpose of this prospective study is to examine the effect of two local anesthetics used in adductor canal blocks, with relation to pain, analgesic consumption, mobility, and pain related interference with activities and…
- Trial name
- NCT02607579
- Testing
- Exparel, Ropivacaine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Monmouth Medical Center
Osteoarthritis, Pain
Safety of Non-delayed Weight Bearing After Total Hip Replacement With Non-Cemented Fiber Metal Taper Stem
The purpose of this study is to determine if full weight bearing following total hip replacement can speed recovery when the hip replacement in the long bone of the leg is not cemented into the bone.
- Trial name
- NCT00179088
- Testing
- Patient may be able to put weight on the operated leg
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Knee Osteoarthritis
An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA
An Open-label, 8-Week Study to Compare the Comfort and Ease of Use of Five Different Treatment Regimens for CNTX 4975-05 Intra-articular Injection in Subjects with Chronic, Moderate-to-Severe Osteoarthritis Knee Pain.
- Trial name
- NCT03661996
- Testing
- CNTX-4975-05, Lidocaine without epinephrine, ElastoGel
- Where
- 28 sites in United States
- Volunteers
- 854 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis Knee
Effect of Mesenchymal Stem Cells in Primary Knee Osteoarthritis
Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. Incidence and prevalence of osteoarthritis rise with increasing age.
- Trial name
- NCT05783154
- Testing
- Autologous Adipose Tissue-Derived Mesenchymal Stem Cell
- Where
- Bangladesh
- Volunteers
- 84 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Opioid Use, Opioid Dependence
Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption
This project intends to investigate whether (1) a patient-maintained opioid diary provides an accurate measure of opioid consumption (morphine equivalents), (2) improved patient educational materials decrease narcotic…
- Conditions
- Opioid Use, Opioid Dependence, Knee Pain Chronic, Knee Osteoarthritis
- Trial name
- NCT03534102
- Testing
- Improved Opioid-Tapering Instructions, Clinical Patient Educator
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis of the Knee
Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee
The purpose of this study was to assess the safety and efficacy of FX006 for the treatment of pain in patients with osteoarthritis of the knee.
- Trial name
- NCT02357459
- Testing
- FX006, TCA IR 40
- Where
- 38 sites in United States, Australia and 6 more
- Volunteers
- 486 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Disease, Knee Deformity
Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery
The ultrasound-guided selective blockade of the saphenous nerve in the adductor canal provides effective analgesia and reduces postoperative pain in patients undergoing arthroscopic medial meniscectomy.
- Conditions
- Knee Disease, Knee Deformity, Knee Pain Chronic, Knee Arthropathy
- Trial name
- NCT06084403
- Testing
- 20 ml volume adductor canal block, 30 ml volume adductor canal block, 40 ml volume adductor canal block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa City Hospital
Knee OA, Osteoarthritis
Comparing Exercise Programs for Managing Knee Osteoarthritis
The goal of this clinical trial is to assess and compare the effectiveness of three different exercise modalities-whole-body vibration exercise, progressive resistance exercise, and home-based exercise -in improving quadriceps…
- Conditions
- Knee OA, Osteoarthritis, Osteoarthritis (OA) of the Knee
- Trial name
- NCT06711341
- Testing
- Whole-body Vibration (WBV) Training, Progressive Resistance Exercise (PRE), Home-Based Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Uludag University
Knee Pain Chronic
Quantum Molecular Resonance (QMR) Rehabiltative Treatment of Knee Osteoarthritis
Gonarthrosis (osteoarthritis of the knee (OA) is a chronic-degenerative disease, characterized by progressive joint damage up to disability that affects about 40% of people over 65 years of age.
- Trial name
- QMR (NCT06239805)
- Testing
- QMR
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- G. d'Annunzio University
Osteoarthritis, Knee
Kinesiotaping in Knee Osteoarthritis
Kinesiotape is one of the treatment choices for the patients with knee osteoarthritis. Unlike the brace, it seems to be an important advantage in kinesiotape application in that it permits the movement of the joint.
- Trial name
- NCT05351996
- Testing
- Kinesiotape, Home-based exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Bozyaka Training and Research Hospital
Knee Osteoarthritis, Knee Arthritis
Intra-Operative Adductor Canal Blocks
Adductor canal blocks (ACB) have been recommended in total knee arthroplasty (TKA) to provide better control of post-operative pain, facilitate early ambulation, and reduce length of stay in the hospital.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Anesthesia
- Trial name
- NCT05601427
- Testing
- aACB, sACB
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
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