Clinical trials: Osteoarthritis Pain of the Knee, open to volunteers
Knee Osteoarthritis, Osteoarthritis, Knee
US-Guided Saphenous Block in Knee OA
The purpose of this prospective, randomized, open-label, active-controlled clinical trial is to evaluate the clinical and sonographic effects of ultrasound-guided (US-guided) high-volume saphenous nerve block combined with…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Knee, Gonarthrosis, Knee Pain
- Trial name
- SAPH-KNEE-OA (NCT07868770)
- Testing
- Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Osteoarthritis, Knee
Ultrasound-Guided Pulsed Radiofrequency In The Treatment Of Patients With Osteoarthritis Knee (USPRFGENOAK)
The purpose of this study is to determine if patients with chronic painful knee osteoarthritis experience meaningful and long-term improvement in pain, function, and analgesic use after ultrasound-guided pulsed radiofrequency of…
- Trial name
- USPRFGENOAK (NCT02915120)
- Testing
- Real Pulsed Radiofrequency
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Hospital Son Llatzer
Knee Osteoarthritis, Amplification
Somatosensory Amplification and Psychological and Functional Status In Patients With Knee Osteoarthritis
As modern society enters the age of an aging population, the prevalence of knee OA continues to increase, which necessitates multi-faceted research.
- Conditions
- Knee Osteoarthritis, Amplification, Kinesiophobia, Psychological Disability
- Trial name
- NCT06753019
- Testing
- survey assessment tools
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Suleyman Demirel University
Osteo Arthritis of the Knee
Lubricin-inspired Osteoarthritis Treatment: a Unique Solution
This goal of this open label study is to evaluate the safety and tolerability of a single intra-articular administration of ABR1 in adults with knee osteoarthritis with a KL grade from 2 to 4.
- Trial name
- LOTUS (NCT07611708)
- Testing
- ABR1
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Pleryon Therapeutics (Hangzhou) Limited
Osteoarthritis of Knee, Osteoarthritis Hip
Cannabinoids for Osteoarthritis Pain Effectiveness Trial
This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians.
- Trial name
- COPE (NCT06878417)
- Testing
- CBD, THC
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Knee Osteoarthritis, Pain
Cabbage Leaf Application in Knee Osteoarthritis
Among non-pharmacological treatment methods, herbal therapies are widely used, and cabbage leaves are recognized for their analgesic and anti-edematous effects.
- Trial name
- NCT07318116
- Testing
- Cabbage leaf compress for knee pain
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Inonu University
Knee Osteoarthritis
Effect of Genicular Arteries Embolization in Symptomatic Knee Osteoarthritis LipioJoint-2
Knee OsteoArthritis (KOA) is a common disease associated with pain and impaired function. Many patients are not relieved of their symptoms with enough efficacy by conservative treatments.
- Trial name
- LIPIOJOINT-2 (NCT06497140)
- Testing
- Ethiodized Oil-based emulsion
- Where
- 3 sites in France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis (OA) of the Knee
Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty
The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a…
- Trial name
- NCT07219888
- Testing
- oral suzetrigine, oral Oxycodone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Louisville
Osteoarthritis, Knee
Effects of Different Collagen Formulations on Knee Osteoarthritis
The purpose of this study is to evaluate and compare the effects of two different collagen supplement formulations on pain, physical function, and overall quality of life in adults with knee osteoarthritis.
- Trial name
- NCT07800780
- Testing
- 10g Hydrolyzed Collagen, 5g Bioactive Collagen Peptide
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Cihangir Türemiş
Obesity, Overweight
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity.
- Conditions
- Obesity, Overweight, Osteoarthritis of the Knee
- Trial name
- NCT07919678
- Testing
- Berobenatide
- Where
- 40 sites in United States, Canada
- Volunteers
- 656 people
- Sponsor
- Pfizer
Knee Osteoarthritis
Knee Pain Ejiao Paste for Knee Osteoarthritis
To explore the analgesic efficacy of Knee Pain Ejiao Paste in the treatment of knee osteoarthritis (Qi and Blood Deficiency Pattern) after 12 weeks, using an Ejiao-free clear paste as a parallel control and incorporating a…
- Trial name
- NCT07504562
- Testing
- Knee Pain Ejiao Paste, Knee Pain Ejiao-free Clear Paste
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- ShuGuang Hospital
Platelet Rich Plasma Injection, Ultrasonography
The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis
The primary objective of this study is to evaluate and compare the effectiveness of ultrasound-guided combined intra-articular and peri-articular platelet-rich plasma (PRP) injections with intra-articular PRP injections alone in…
- Conditions
- Platelet Rich Plasma Injection, Ultrasonography, Gonarthrosis
- Trial name
- NCT07339137
- Testing
- Conservative Therapy, Intra-Articular PRP, Peri-Articular PRP
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis, Knee Pain Chronic
The Effect of RF Genicular Nerve Block Applied in the Preoperative Period on Fast-track Total Knee Arthroplasty
In our study, investigators plan to compare the preoperative RF and genicular nerve ablation approach in patients who underwent TKA(Total Knee Arthroplasty) using the Fast-Track protocol in terms of meeting postoperative pain…
- Trial name
- NCT06239649
- Testing
- Genicular nerve Radiofrequency Ablation block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Knee Arthritis
Cannabidiol (CBD) in Pain Reduction for Knee Osteoarthritis
The purpose of this study is to see if cannabidiol (CBD) orally dissolving tablets (ODTs) can lessen pain, improve function, and improve patient satisfaction in cases of knee osteoarthritis.
- Trial name
- NCT05020028
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Osteoarthritis
The Safety and Efficacy of XytriX (Umbilical Cord-Derived Mesenchymal Stem Cells) in the Treatment of Knee Osteoarthritis
This study aims to study the safety and efficacy of XytriX, an umbilical cord-derived stem cell product, in the treatment of Grade I-IV knee osteoarthritis.
- Trial name
- NCT07487766
- Testing
- Mesenchymal Stem Cell Injection
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- TricelX Inc.
Meniscus Tear
The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears.
- Trial name
- NCT06532851
- Testing
- Progressive Resistance Exercise (PRE), Aerobic Exercise, Control
- Where
- 2 sites in Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Ketogenic Diet to Reduce Osteoarthritis Pain in MCI
Osteoarthritis and mild cognitive impairment are common conditions that share underlying biological processes related to metabolism and inflammation.
- Conditions
- Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis
- Trial name
- KDROP-MCI (NCT07417891)
- Testing
- Well-formulated ketogenic diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Osteoarthritis, Knee, Postoperative Pain
A Randomized Comparison of the Efficacy of the IPACK Block Versus the Popliteal Plexus Block for Posterior Knee Analgesia, in Patients Undergoing a Total Knee Arthroplasty and Receiving a Continuous Distal Femoral Triangle Block
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, including pain arising from the posterior aspect of the knee.
- Trial name
- NCT07876310
- Testing
- Ultrasound-Guided iPACK Block, Ultrasound-Guided Popliteal Plexus Block, Ultrasound-Guided Continuous Femoral Triangle Block
- Volunteers
- 136 people
- Sponsor
- Clinica Santa Maria
Low Back Pain, Radicular Syndrome
Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal Disorders
This pilot randomized controlled trial aims to compare the clinical effectiveness of advanced high-intensity physical therapy modalities with conventional physical therapy in patients suffering from musculoskeletal disorders.
- Conditions
- Low Back Pain, Radicular Syndrome, Sacroiliac Joint Dysfunction, Shoulder Impingement Syndrome
- Trial name
- NCT07903142
- Testing
- Repetitive Peripheral Magnetic Stimulation (rPMS), High-Intensity Laser Therapy (HIL), Extracorporeal Shockwave Therapy (ESWT)
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- BTL Industries Ltd.