Clinical trials: Osteoarthritis of the Knee
Knee Osteoarthritis
Immediate Effects of High-intensity Laser Therapy on Knee Joint Position Sense and Knee Muscle Strength in Patients with Knee Osteoarthritis
The goal of this clinical trial is to compare whether HILT versus Sham-HILT is effective to reduce pain, improve knee joint position sense, and knee muscle strength.
- Trial name
- HILT on KOA (NCT06632119)
- Testing
- high-intensity laser therapy
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Osteoarthritis
Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR)
We hypothesize continuous adductor canal block with steroid adjuvant would offer no inferior analgesics and rehabilitation ability than continuous femoral nerve block for postoperative patients receiving total knee arthroplasty.
- Trial name
- NCT01973530
- Testing
- adductor canal block, femoral nerve block
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Osteoarthritis, Knee
MOTION Clinical Trial
Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with non-surgical treatment.
- Trial name
- NCT06843980
- Testing
- MISHA Knee System, Non-Surgical Treatment
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- Moximed
Osteoarthritis of the Knee
Safety and Feasibility Study of Mesenchymal Trophic Factor (MTF) for Treatment of Osteoarthritis
Allogeneic mesenchymal trophic factors (MTF) from human umbilical cord tissue-derived mesenchymal stem cells (UC-MSC) injected into the knee joints of 20 patients (group 1) or injected subcutaneously into 20 patients (group 2) is…
- Trial name
- NCT02003131
- Testing
- Trophic factors from umbilical cord mesenchymal stem cells
- Where
- Panama
- Sponsor
- Translational Biosciences
Knee Osteoarthritis
Is Pulsed Ultrasound Treatment Effective in Knee Osteoarthritis
Osteoarthritis is a progressive rheumatic disease which is the most common cause of musculoskeletal pain and functional impairment, particularly in the elderly group. The most common form is knee osteoarthritis.
- Trial name
- NCT03705039
- Testing
- Pulsed Ultrasound Treatment, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Dokuz Eylul University
Knee Osteoarthritis
Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis
The goal of this clinical trial is to investigate the effect of oral hyaluronate in patients with knee osteoarthritis. The main question it aims to answer is: the therapeutic effect in the combined treatment of oral nutritional…
- Trial name
- NCT07033312
- Testing
- oral hyaluronate and injection, hyaluronate injection
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Taichung Veterans General Hospital
Knee Osteoarthritis
The Effect of Theory-driven Physiotherapy on Physical Activity in Knee OA.
Knee osteoarthritis (OA) is a leading cause of pain, disability, and reduced physical functioning worldwide. Although physiotherapy and physical activity are recommended as first-line treatments, many individuals with knee OA do…
- Trial name
- EXPLOR (NCT07901881)
- Testing
- EXPLOR-3
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Mark van Loo
Knee Osteoarthritis
Strength Training for ARthritis Trial
The primary purpose of this study is to compare the effects of a high and low intensity strength training programs vs. a control group on knee pain and compressive joint forces.
- Trial name
- START (NCT01489462)
- Testing
- High Intensity Strength Training, Low Intensity Strength Training, Attention Control
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Wake Forest University
Knee Osteoarthritis
Kinesiophobia, Pain, Functional Status and Self-Efficacy in Patients With Knee Osteoarthritis
Objective: The aim of this study is to examine the relationship between kinesiophobia, pain, functional status and self efficacy in patients with knee osteoarthritis.
- Trial name
- NCT05036551
- Testing
- Kellgren Lawrence classification
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Hacettepe University
Knee Osteoarthritis, Genicular Nerve Block
Phenol Neurolysis Versus Local Anesthetic Plus Steroid Genicular Nerve Block in Knee Osteoarthritis
This study aims to evaluate two different ultrasound-guided procedures for patients with knee osteoarthritis (gonarthrosis) who did not benefit from conservative treatments.
- Trial name
- NCT07267039
- Testing
- Phenol Injection, Bupivacaine + Triamcinolone Acetonide Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Salim Sencar
Knee Osteoarthritis
A Trial to Evaluate the Safety, Tolerability, and Efficacy of NCR100 Injection in the Treatment of Subjects With KOA
This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It is a dose-escalating, open label study in adult KOA subjects.
- Trial name
- NCR100 (NCT06049342)
- Testing
- NCR100 injection
- Volunteers
- 12 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Osteoarthritis
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement
The aim of the study is to determine whether the AQUACEL™ Ag SURGICAL cover dressing is successful in reducing the incidence of wound infection in high risk patients following total knee replacement.
- Trial name
- NCT02217202
- Testing
- Aquacel Ag dressing
- Sponsor
- Golden Jubilee National Hospital
Knee Osteoarthritis
Comparison of Effect of Virtual Reality and Kinetic Chain Exercises in Knee Osteoarthritis
It is necessary to explore the novel rehabilitation strategies to treat knee osteoarthritis. Although kinetic chain exercises have shown efficacy but there is growing interest in Virtual Reality training using Xbox Kinect because…
- Trial name
- NCT06511557
- Testing
- Non immersive virtual reality ( xbox kinetic), Kinetic chain exercises
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Knee Osteoarthritis
Efficacy and Safety of ELIXCYTE Intra-articular Injection in Subject With Knee Osteoarthritis
This is a Phase III, double-blinded, placebo-controlled, multicenter study to investigate the efficacy and safety of a new study intervention, ELIXCYTE, compared to placebo (normal saline) in subjects with knee osteoarthritis.
- Trial name
- NCT05526001
- Testing
- ELIXCYTE, Saline
- Where
- 4 sites in Taiwan
- Volunteers
- 165 people
- Sponsor
- UnicoCell Biomed CO. LTD
Knee Osteoarthritis
Genicular Artery Embolization vs Nerve Ablation Intervention (GENI) for Knee Osteoarthritis
The genicular artery embolization vs nerve ablation intervention (GENI) knee OA study is a three-arm randomized controlled trial to evaluate symptoms of knee osteoarthritis (OA) in patients after receiving one of three…
- Trial name
- NCT06166628
- Testing
- Geniculate artery embolization, Genicular nerve phenol nerve ablation, Skin infiltration of 2cc of 0.25% bupivacaine at the knee
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- David Clinkard
Osteo Arthritis Knee
High Versus Low Adductor Canal Block
The investigators will be comparing the efficacy of two different techniques for performing an adductor canal block to the saphenous nerve as a part of the multimodal pain control regimen for total knee arthroplasty.
- Trial name
- NCT04155983
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Carilion Clinic
Knee Osteoarthritis
Percutaneous Electrical Stimulation, Education and Exercise Program in Patients With Knee Osteoarthritis
The purpose of this study is to compare the effectiveness of percutaneous electrotherapy treatment with transcutaneous and placebo.
- Trial name
- NCT05955430
- Testing
- Therapeutic exercise, Pain education, Percutaneous electrical stimulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Josue Fernandez Carnero
Osteoarthritis Knee
Efficacy and Safety Study of Individualized and Standardized Acupuncture Treatment for Knee Osteoarthritis
The purpose of this study is to verify the efficacy and safety of acupuncture treatments (Individualized, Standardized acupuncture) for patients with knee osteoarthritis (OA).
- Trial name
- NCT01569230
- Testing
- Standardized Acupuncture, Individualized Acupuncture, Waiting
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Eun Jung Kim
Osteoarthritis
Influence of Whole Body Vibration Compared to Conventional Physiotherapy in Patients With Gonarthrosis
40 patients with osteoarthritis of the knee will be randomly assigned to conventional physiotherapy on the one and whole body vibration exercises on the other hand.
- Trial name
- NCT01037972
- Testing
- Conventional physiotherapy, Whole body vibration
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Cologne
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Clinical Evaluation of Vanguard DD RP
This is a single cohort, prospective study of performance and safety of the Vanguard Deep Dish Rotating Platform (DD RP) cementless fixation with the goal to acquire clinical outcomes data and evaluate the performance of the…
- Conditions
- Knee Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT04076202
- Testing
- Cementless Vanguard DD RP
- Where
- Austria
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
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