Clinical trials: Osteoarthritis of the Knee
Meniscus Injury, Knee Osteoarthritis
Knee Arthroscopy Cohort Southern Denmark (KACS)
PURPOSE: To investigate the natural time course of patient-reported outcomes after meniscus surgery and identify factors associated with good and bad outcome after surgery.
- Trial name
- KACS (NCT01871272)
- Testing
- Arthroscopic Meniscus Surgery
- Where
- 4 sites in Denmark
- Volunteers
- 491 people
- Sponsor
- University of Southern Denmark
Osteoarthritis
Evaluation of Diprospan Injection to the Knee on Rehabilitation of Patients After TKR of the Contralateral Knee
This study is performed to assess the influence of intraarticular injection of 2ml Diprospan (wich contains 4mg Betamethasone sodium phosphate and 10mg Betamethasone dipropionate) into osteoarthritic knee in patients who undergo…
- Trial name
- NCT00542139
- Testing
- Betamethasone, Bupivocaine
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Knee Osteoarthritis
Effect of Probiotic Supplements on Osteoarthritis Outcomes
Dysbiosis of the gut microbiota is believed to contribute to the development and progression of osteoarthritis (OA), suggesting a role for probiotics in the treatment of OA.
- Trial name
- ProOA23 (NCT06459700)
- Testing
- Probiotic supplements
- Where
- Sweden
- Volunteers
- 86 people
- Sponsor
- Lund University
Osteo Arthritis Knee, Osteoarthritis, Knee
OA Optimization Program Pilot Trial
Total joint replacement is a highly successful treatment option for people affected by severe osteoarthritis (OA), however, the mismatch between resources and demand for this surgery means that many patients face long wait times…
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis
- Trial name
- NCT05389371
- Testing
- Alberta Healthy Living Program, Alberta Obesity Centre Program, Osteoarthritis advice
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Calgary
Knee Osteoarthritis
Non-surgical Treatment of Knee Osteoarthritis - a Comparison of Effects in 2200 Patients
The purpose of this study is to assess whether radiographic osteoarthritis severity (OA; Kellgren-Lawrence scale) is associated with self-reported improvement in pain after non-surgical treatments (physiotherapy, pain killers…
- Trial name
- NCT02091830
- Testing
- Paracetamol and nonsteroidal antiinflammatory drug (NSAID), Physiotherapy, Cortisone Injection
- Where
- Denmark
- Volunteers
- 2,262 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis, Knee
Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC
A randomized blinded study is conducted comparing 2 different knee prostheses. Range of motion (ROM), pain, feel of prosthesis, satisfaction and ability to do daily activities are registered at intervals up to one year postop…
- Trial name
- NCT00294528
- Testing
- Nexgen LPS-flex and AGC
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Hvidovre University Hospital
Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
Platelet Rich Plasma for Musculoskeletal Conditions
The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain…
- Conditions
- Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Shoulder
- Trial name
- PRP for MSK (NCT07231471)
- Testing
- Platelet Rich Plasma Injection, Platelet Rich Plasma Preparation
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Utah
Osteoarthritis, Knee
Persona TKA With iASSIST Knee System and iASSIST Knee System
The purpose of this study is to compare the accuracy of knee component alignment between patients operated with iASSIST Knee (Investigational group) versus patients operated without iASSIST Knee (Control group) using the same…
- Trial name
- NCT03227692
- Testing
- Persona Knee System, Total Knee Arthroplasty, iAssist Knee
- Where
- 3 sites in Japan
- Volunteers
- 93 people
- Sponsor
- Zimmer Biomet
Osteoarthritis of the Knee
Cabbage Leaf Wraps in Osteoarthritis of the Knee
This randomised controlled trial aims to investigate the efficacy of cabbage leaf cataplasms in the treatment of primary symptomatic osteoarthritis of the knee.
- Trial name
- KoGon (NCT02027792)
- Testing
- Cabbage leave wraps, Diclofenac Gel
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universität Duisburg-Essen
Osteoarthritis of Knee
Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL)
This phase III clinical study will be conducted in Brazilian research sites. It will be included in the study 314 participants diagnosed with primary knee OA according to the classification criteria of the ACR.
- Trial name
- GLACIAL (NCT02830919)
- Testing
- Glucosamine and chondroitin sulfate combination (Eurofarma), Glucosamine and chondroitin sulfate combination (Zodic)
- Where
- 4 sites in Brazil
- Volunteers
- 627 people
- Sponsor
- Eurofarma Laboratorios S.A.
Osteoarthritis
Rosehip Powder for Knee Osteoarthritis
The aim of this study is to compare three combinations of preparations in a comparative trial program on rosehip powder for knee OA.
- Trial name
- NCT01430481
- Testing
- Rosehip powder
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Frederiksberg University Hospital
Osteoarthritis
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Subcutaneous Injections of ABT-981 in Patients With Osteoarthritis of the Knee
To assess the safety, tolerability and pharmacokinetics of ABT-981 in patients with osteoarthritis of the knee.
- Trial name
- NCT01668511
- Testing
- ABT-981
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Knee Osteoarthritis, Ultrasound Exams
Applications of Ultrasound and Physical Parameters in Assessing Fall Risk in Patients With Knee Osteoarthritis
Falls are a significant issue for patients with knee osteoarthritis, as they can lead to hospitalization or even more severe consequences. Therefore, it is crucial to assess fall risk early in rehabilitation clinics.
- Conditions
- Knee Osteoarthritis, Ultrasound Exams, Fall Risk, Sarcopenia in Elderly
- Trial name
- UPPFR-KneeOA (NCT06882928)
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Clinical Trial Center
Gonarthrosis; Primary, Gonarthrosis
Comparison of Multiradius and Singleradius Total Knee Arthroplasty
The Investigators would like to compare multiradius and single-radius total knee arthroplasty using with association between sagittal patellar offset and anterior knee pain in subjects having undergone bilateral total knee…
- Conditions
- Gonarthrosis; Primary, Gonarthrosis, Gonarthrosis; Primary, Bilateral, Knee Osteoarthritis
- Trial name
- NCT04364971
- Testing
- singleradius and multiradius total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 494 people
- Sponsor
- Bezmialem Vakif University
Total Knee Arthroplasty, Knee Osteoarthritis
IMProving Outcomes With ACT After Knee Surgery
Regarding psychosocial factors and outcomes in total knee arthroplasty (TKA), most of the current literature and the investigators' previous work suggest that depression, anxiety and pre-operative pain strongly predict worse…
- Trial name
- IMPACTS (NCT06483191)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Belfast Health and Social Care Trust
Osteoarthritis
Efficiency and Usability of the Iontophoretic Patch Feeligreen Diclofenac in Treating Acute Osteoarthritic Knee Pain
The aim of the study is to evaluate the antalgic efficacity of Feeligreen® patch on osteoarthritic knee pain acute. This patch work by diffusion controlled by iontophoresis allowing an improvement of transdermal diffusion of…
- Trial name
- NCT02784691
- Testing
- Feeligreen patch
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoarthritis, Knee
Does Tourniquet Use in Total Knee Replacement Improve Fixation
Although a tourniquet may reduce bleeding during total knee replacement (TKA), and thereby improve fixation, it might also cause complications.
- Trial name
- NCT01470482
- Testing
- No use of tourniquet, Tourniquet
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Per Aspenberg
Osteoarthritis, Knee, Post-traumatic Osteoarthritis
Preventing Injured Knees From osteoArthritis: Severity Outcomes
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction.
- Conditions
- Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
- Trial name
- PIKASO (NCT06096259)
- Testing
- Metformin
- Where
- 9 sites in United States
- Volunteers
- 512 people
- Sponsor
- Brigham and Women's Hospital
Knee Osteoarthritis
Retrospective Evaluation of the Long-term Effectiveness of the CR500™ SINGLE-DOSE GEL Medical Device in Patients With Knee Osteoarthritis (KOA)
Evaluate the long-term efficacy of the CR500™ therapy in patients with knee OA.
- Trial name
- NCT07322770
- Testing
- CR 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Knee Osteoarthritis
Impact of Personalized Rehabilitation Guidance
To investigate the impact of personalized rehabilitation guidance based on the WeChat Official Accounts Platform on the functional recovery and quality of life of patients with knee osteoarthritis (KOA).Ninety patients diagnosed…
- Trial name
- NCT06754241
- Testing
- conventional nursing care, Intervention Care
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yan Dong
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